Rat sciatic nerve repair with a poly-lactic-co- glycolic acid scaffold and nerve growth factor releasing microspheres

Microsurgery ◽  
2011 ◽  
Vol 31 (4) ◽  
pp. 293-302 ◽  
Author(s):  
Ralph de Boer ◽  
Andrew M. Knight ◽  
Andreas Borntraeger ◽  
Marie-Noëlle Hébert-Blouin ◽  
Robert J. Spinner ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Glycolic Acid ◽  
Nerve Repair ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

Nerve Growth Factor Facilitates Regeneration across Nerve Gaps: Morphological and Behavioral Studies in Rat Sciatic Nerve

1993 ◽  
Vol 119 (2) ◽  
pp. 176-191 ◽  
Author(s):  
Albert Derby ◽  
V.Wayne Engleman ◽  
Gregory E. Frierdich ◽  
Gabrielle Neises ◽  
Stephen R. Rapp ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Nerve Growth ◽  
Rat Sciatic Nerve ◽  
Behavioral Studies

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

Nature ◽  
1987 ◽  
Vol 330 (6149) ◽  
pp. 658-659 ◽  
Author(s):  
Dan Lindholm ◽  
Rolf Heumann ◽  
Michael Meyer ◽  
Hans Thoenen
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Interleukin 1 ◽  
Neuronal Cells ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

scholarly journals EFFECTS OF CATECHOLAMINES AND 4-METHYLCATECHOL ON THE SYNTHESIS AND SECRETION OF NERVE GROWTH FACTOR BY RAT SCIATIC NERVE SEGMENTS IN CULTURE

1990 ◽  
Vol 11 (1) ◽  
pp. 61-65 ◽  
Author(s):  
RYOSUKE IKEGAMI ◽  
YOSHIKO FURUKAWA ◽  
KYOSUKE KAECHI ◽  
KYOZO HAYASHI ◽  
SHOEI FURUKAWA
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

The Role of Nerve Growth Factor in Ginsenoside Rg1-Induced Regeneration of Injured Rat Sciatic Nerve

2015 ◽  
Vol 78 (21-22) ◽  
pp. 1328-1337 ◽  
Author(s):  
Dong-Sheng Huo ◽  
Ming Zhang ◽  
Zhi-Ping Cai ◽  
Chao-Xuan Dong ◽  
He Wang ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Ginsenoside Rg1 ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

Repairing rat sciatic nerve injury by a nerve-growth-factor-loaded, chitosan-based nerve conduit

2012 ◽  
Vol 59 (5) ◽  
pp. 388-394 ◽  
Author(s):  
Hongkui Wang ◽  
Qing Zhao ◽  
Weijia Zhao ◽  
Qiong Liu ◽  
Xiaosong Gu ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Nerve Conduit ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

Nerve Growth Factor of Red Nucleus Involvement in Pain Induced by Spared Nerve Injury of the Rat Sciatic Nerve

2009 ◽  
Vol 34 (9) ◽  
pp. 1612-1618 ◽  
Author(s):  
Yuan-Yuan Jing ◽  
Jun-Yang Wang ◽  
Xiao-Li Li ◽  
Zhi-Hong Wang ◽  
Liu Pei ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Nerve Injury ◽  
Red Nucleus ◽  
Spared Nerve Injury ◽  
Nerve Growth ◽  
Rat Sciatic Nerve

scholarly journals Antihypernociceptive and Neuroprotective Effects of the Aqueous and Methanol Stem-Bark Extracts of Nauclea pobeguinii (Rubiaceae) on STZ-Induced Diabetic Neuropathic Pain

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Eric Gonzal Tsafack ◽  
Marius Mbiantcha ◽  
Gilbert Ateufack ◽  
Stephanie Flore Djuichou Nguemnang ◽  
William Nana Yousseu ◽  
...  
Keyword(s):  
Body Weight ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Stem Bark ◽  
Nerve Growth ◽  
Methanol Extracts ◽  
Tnf Α ◽  
Nauclea Pobeguinii

The greatest common and devastating complication of diabetes is painful neuropathy that can cause hyperalgesia and allodynia. It can disturb psychosocial functioning by increasing levels of anxiety and depression. This work was designed to evaluate the antihyperalgesic, antidepressant, and anxiolytic-like effects of the aqueous and methanol extracts of Nauclea pobeguinii stem-bark in diabetic neuropathy induced by streptozotocin in mice. Diabetic neuropathy was induced in mice by the intraperitoneal administration of 200 mg/kg streptozotocin (STZ) to provoke hyperglycemia. Nauclea pobeguinii aqueous and methanol extracts at the doses of 150 and 300 mg/kg were administered by oral route, and their effects were evaluated on antihyperalgesic activity (Von Frey filaments, hot plate, acetone, and formalin tests), blood glucose levels, body weight, serum, sciatic nerve proinflammatory cytokines (TNF-α, IL-1β, and IL-6) and sciatic nerve growth factor (IGF and NGF) rates, depression (open field test, forced swimming test, tail suspension test), and anxiety (elevated plus maze, light-dark box test, social interaction). Oral administration of Nauclea pobeguinii stem-bark aqueous and methanol extracts (150 and 300 mg/kg) produced antihyperalgesic, antidepressant, and anxiolytic-like effects in STZ-induced diabetic neuropathic mice. Extracts also triggered a decrease in glycaemia and increased body weight in treated animals. They also significantly ( p <0.001) reduced tumour necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6 and significantly ( p <0.001) increased nerve growth factor (NGF) and insulin-like growth factor (IGF) in sciatic nerves. The results of this study confirmed that Nauclea pobeguinii aqueous and methanol extracts possess antihyperalgesic, antidepressant, and anxiolytic activities and could be beneficial therapeutic agents.

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