Vascularised bone grafts in the treatment of long bone defects

Microsurgery ◽  
1994 ◽  
Vol 15 (7) ◽  
pp. 479-484 ◽  
Author(s):  
Theodore H. Xenakis ◽  
Konstantinos N. Malizos ◽  
Alexandros E. Beris ◽  
Marios Vekris ◽  
Anastasios D. Georgoulis ◽  
...  
Keyword(s):  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone

Combined use of platelet-rich plasma and autologous bone grafts in the treatment of long bone defects in mini-pigs

Injury ◽  
2010 ◽  
Vol 41 (7) ◽  
pp. 717-723 ◽  
Author(s):  
M. Hakimi ◽  
P. Jungbluth ◽  
M. Sager ◽  
M. Betsch ◽  
M. Herten ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Combined Use ◽  
Autologous Bone ◽  
Autologous Bone Grafts ◽  
Mini Pigs

scholarly journals Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Jian Lu ◽  
Qi-Yang Wang ◽  
Jia-Gen Sheng
Keyword(s):  
Bone Graft ◽  
Bone Metabolism ◽  
Cell Communication ◽  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Safety Issues ◽  
Cell Based Therapy ◽  
Bone Graft Substitutes ◽  
Autologous Bone Grafts

Nonunion with bone defects, a common complication after long bone fracture, is a major challenge for orthopaedic surgeons worldwide because of the high incidence rate and difficulties in achieving successful treatment. Bone defects are the main complications of nonunion. The conventional biological treatments for nonunion with bone defects involve the use of autologous bone grafts or bone graft substitutes and cell-based therapy. Traditional nonunion treatments have always been associated with safety issues and various other complications. Bone grafts have limited autologous cancellous bone and there is a risk of infection. Additionally, problems with bone graft substitutes, including rejection and stimulation of bone formation, have been noted, and the health of the stem cell niche is a major consideration in cell-based therapy. In recent years, researchers have found that exosomes can be used to deliver functional RNA and mediate cell-to-cell communication, suggesting that exosomes may repair bone defects by regulating cells and cytokines involved in bone metabolism. In this review, we highlight the possible relationships between risk factors for nonunion and exosomes. Additionally, we discuss the roles of exosomes in bone metabolism and bone regeneration.

scholarly journals Reconstruction of extremity long bone defects with vascularized fibula bone grafts

2019 ◽  
Vol 2019 ◽  
Author(s):  
Corinne Wee ◽  
Daniel Ruter ◽  
Steven Schulz ◽  
Geoffroy Sisk ◽  
Julie West ◽  
...  
Keyword(s):  
Bone Grafts ◽  
Bone Defects ◽  
Long Bone ◽  
Vascularized Fibula

Bone transport over an intramedullary nail for reconstruction of long bone defects in tibia

2007 ◽  
Vol 128 (8) ◽  
pp. 801-808 ◽  
Author(s):  
Chang-Wug Oh ◽  
Hae-Ryong Song ◽  
Jae-Young Roh ◽  
Jong-Keon Oh ◽  
Woo-Kie Min ◽  
...  
Keyword(s):  
Intramedullary Nail ◽  
Bone Defects ◽  
Bone Transport ◽  
Long Bone

scholarly journals Biocompatibility and Bone Formation of Flexible, Cotton Wool-like PLGA/Calcium Phosphate Nanocomposites in Sheep

2011 ◽  
Vol 5 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Oliver D Schneider ◽  
Dirk Mohn ◽  
Roland Fuhrer ◽  
Karina Klein ◽  
Käthi Kämpf ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Antimicrobial Properties ◽  
Drill Hole ◽  
Bone Defects ◽  
Long Bone ◽  
Minimal Amount ◽  
Cotton Wool

Background: The purpose of this preliminary study was to assess the in vivo performance of synthetic, cotton wool-like nanocomposites consisting of a biodegradable poly(lactide-co-glycolide) fibrous matrix and containing either calcium phosphate nanoparticles (PLGA/CaP 60:40) or silver doped CaP nanoparticles (PLGA/Ag-CaP 60:40). Besides its extraordinary in vitro bioactivity the latter biomaterial (0.4 wt% total silver concentration) provides additional antimicrobial properties for treating bone defects exposed to microorganisms. Materials and Methods: Both flexible artificial bone substitutes were implanted into totally 16 epiphyseal and metaphyseal drill hole defects of long bone in sheep and followed for 8 weeks. Histological and histomorphological analyses were conducted to evaluate the biocompatibility and bone formation applying a score system. The influence of silver on the in vivo performance was further investigated. Results: Semi-quantitative evaluation of histology sections showed for both implant materials an excellent biocompatibility and bone healing with no resorption in the adjacent bone. No signs of inflammation were detectable, either macroscopically or microscopically, as was evident in 5 µm plastic sections by the minimal amount of inflammatory cells. The fibrous biomaterials enabled bone formation directly in the centre of the former defect. The area fraction of new bone formation as determined histomorphometrically after 8 weeks implantation was very similar with 20.5 ± 11.2 % and 22.5 ± 9.2 % for PLGA/CaP and PLGA/Ag-CaP, respectively. Conclusions: The cotton wool-like bone substitute material is easily applicable, biocompatible and might be beneficial in minimal invasive surgery for treating bone defects.

scholarly journals Augmentation of Peri-implant Bone Defects with Different Bone Grafts and Guided Bone Regeneration:

2006 ◽  
Vol 15 (3) ◽  
pp. 82-88 ◽  
Author(s):  
Weijian Zhong ◽  
Guowu Ma ◽  
Yi Wang ◽  
Ryo Tamamura ◽  
Jing Xiao
Keyword(s):  
Bone Regeneration ◽  
Bone Grafts ◽  
Bone Defects ◽  
Guided Bone Regeneration
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