scholarly journals Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case–Control study

2019 ◽  
Vol 7 (8) ◽  
Author(s):  
Li Wang ◽  
Wenhui Zhao ◽  
Jiajing Hong ◽  
Fanglin Niu ◽  
Jing Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Control Study ◽  
Il1b Gene ◽  
Uygur Population

scholarly journals Association of genetic polymorphisms in XRCC4, XRCC5, XRCC6 and XRCC7 in cervical cancer susceptibility from rural population: a hospital based case-control study

2018 ◽  
Vol 6 (7) ◽  
pp. 2453
Author(s):  
Kailas D. Datkhile ◽  
Madhavi N. Patil ◽  
Pratik P. Durgawale ◽  
Kalpita S. Korbu ◽  
Shreepad A. Joshi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Rural Population ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Development ◽  
Pcr Rflp ◽  
Cervical Cancer Development ◽  
Control Study

Background: Cervical cancer is a major concern of health risk, moreover the leading cause of cancer causing deaths in women of rural India. This study was aimed to assess the risk of cervical cancer development in association with polymorphisms in XRCC4, XRCC5, XRCC6 and XRCC7 genes in rural population of south-western Maharashtra.Methods: This study included 350 cervical cancer proven cases and 400 age and sex matched controls. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the association XRCC4, XRCC6 and XRCC7 gene polymorphisms with cervical cancer development in women of Western Maharashtra.Results: The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XRCC4, XRCC5 and XRCC6. 6721 >T allele of XRCC7 (6721G>T) (OR= 2.34; 95% CI= (2.34 (1.60-3.43); p= <0.0001) significantly increased the risk of cervical cancer.Conclusions: This study indicates that XRCC7 gene polymorphisms play a role in modifying genetic susceptibility of individuals towards cervical cancer among women from rural Maharashtra. This case-control study also revealed negative association of XRCC6 gene in cervical carcinogenesis in the rural Indian population.

scholarly journals A case-control study of cervical cancer screening in north east Scotland.

BMJ ◽  
1985 ◽  
Vol 290 (6481) ◽  
pp. 1543-1546 ◽  
Author(s):  
J E Macgregor ◽  
S M Moss ◽  
D M Parkin ◽  
N E Day
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Case Control Study ◽  
Case Control ◽  
North East ◽  
Control Study

Genetic polymorphism of miR-218-2 (rs11134527) in cervical cancer: a case-control study in the Bangladeshi women

MicroRNA ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Farhana Nazneen ◽  
Md. Shalahuddin Millat ◽  
Md. Abdul Barek ◽  
Md. Abdul Aziz ◽  
Mohammad Sarowar Uddin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Case Control Study ◽  
Case Control ◽  
Recessive Model ◽  
Cancer Type ◽  
Increased Risk ◽  
Hardy Weinberg Equilibrium ◽  
Control Study ◽  
Healthy Females

Background: The prevalence of Cervical Cancer (CC) is disproportionately higher in developing countries. It is the second most frequent cancer type among Bangladeshi women and the primary cause of morbidity and mortality. However, no previous data reported the association of miR-218-2 gene polymorphisms in Bangladeshi cervical cancer patients. Aim: This case-control study was designed to find the link between the rs11134527 polymorphism in miR-218-2 and CC. Methods: A total of 488 subjects were recruited, comprising 256 cervical cancer patients and 232 healthy females. Genotyping was conducted with the tetra-primer ARMS-PCR technique to detect the association. Results: The results of genotype data showed that rs11134527 obeyed the Hardy-Weinberg equilibrium in both CC cases and controls (P >0.05). Overall, the polymorphism was found to be significantly associated with an increased risk of cervical cancer with AG genotype (AG vs. GG: OR = 2.26, 95% Cl = 1.40-3.66, P = 0.0008), AA genotype (AA vs. GG: OR = 3.64, 95% Cl = 2.17-6.10, P <0.0001), dominant model (AG+AA vs. GG: OR = 2.75, 95% Cl = 1.75-4.31, P <0.0001), recessive model (AA vs. GG+AG: OR = 2.08, 95% Cl = 1.41-3.08, P = 0.0002), and A allele (A vs. G: OR = 1.94, 95% Cl = 1.51-2.51, P <0.0001). All of these correlations remained statistically significant after performing Bonferroni correction (P <0.008). Conclusion: Our study suggests that the rs11134527 polymorphism in the miR-218-2 gene contributes to the susceptibility of CC in Bangladeshi women.

A case-control study of reproductive risk factors associated with cervical cancer

1994 ◽  
Vol 59 (4) ◽  
pp. 476-482 ◽  
Author(s):  
Bishwa Nath Mukherjee ◽  
Subrata Sengupta ◽  
Salil Chaudhuri ◽  
Liton Naha Biswas ◽  
Pradip Maiti
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Reproductive Risk ◽  
Factors Associated ◽  
Reproductive Risk Factors ◽  
Control Study
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