scholarly journals MMP ‐14 single‐nucleotide polymorphisms are related to steroid‐induced osteonecrosis of the femoral head in the population of northern China

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Yuxin Qi ◽  
Jiaqi Wang ◽  
Mingqi Sun ◽  
Chao Ma ◽  
Tianbo Jin ◽  
...  
Keyword(s):  
Femoral Head ◽  
Single Nucleotide Polymorphisms ◽  
Northern China ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25177-25188 ◽  
Author(s):  
Junyu Chen ◽  
Wanlin Liu ◽  
Yuju Cao ◽  
Xiyang Zhang ◽  
Yongchang Guo ◽  
...  
Keyword(s):  
Femoral Head ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Association of TIMP4 gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6270
Author(s):  
Jiaqi Wang ◽  
Feimeng An ◽  
Yuju Cao ◽  
Hongyan Gao ◽  
Mingqi Sun ◽  
...  
Keyword(s):  
Femoral Head ◽  
Additive Model ◽  
Northern China ◽  
Additive Models ◽  
Gene Variants ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Link Type ◽  
Intravascular Thrombosis ◽  
Normal Individuals

BackgroundIn clinical treatment, the use of steroid hormones is an important etiological factor of non-traumatic osteonecrosis of the femoral head (ONFH) risk. As an endogenous inhibitor of matrix metalloproteinases (MMPs) in the extracellular matrix, the expression of tissue inhibitors of metalloprotease-4 (TIMP4) plays an essential role in cartilage and bone tissue damage and remodeling, vasculitis formation, intravascular thrombosis, and lipid metabolism.MethodsThis study aimed to detect the association between TIMP4 polymorphism and steroid-induced ONFH. We genotyped seven single-nucleotide polymorphisms (SNPs) in TIMP4 genes and analyzed the association with steroid-induced ONFH from 286 steroid-induced ONFH patients and 309 normal individuals.ResultsWe performed allelic model analysis and found that the minor alleles of five SNPs (rs99365,rs308952,rs3817004,rs2279750, andrs3755724) were associated with decreased steroid-induced ONFH (p = 0.02,p = 0.03,p = 0.04,p = 0.01,p = 0.04, respectively).rs2279750showed a significant association with decreased risk of steroid-induced ONFH in the Dominant and Log-additive models (p = 0.042,p = 0.028, respectively), andrs9935,rs30892, andrs3817004were associated with decreased risk in the Log-additive model (p = 0.038,p = 0.044,p = 0.042, respectively). In further stratification analysis, TIMP4 gene variants showed a significant association with steroid-induced ONFH in gender under the genotypes. Haplotype analysis also revealed that “TCAGAC” and “CCGGAA” sequences have protective effect on steroid-induced ONFH.ConclusionOur results indicate that five TIMP4 SNPs (rs99365,rs308952,rs3817004rs2279750, andrs3755724) are significantly associated with decreased risk of steroid-induced ONFH in the population of northern China.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide
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