scholarly journals Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome

2018 ◽  
Vol 6 (4) ◽  
pp. 533-540 ◽  
Author(s):  
Abram B. Kamiza ◽  
Ling-Ling Hsieh ◽  
Reiping Tang ◽  
Huei-Tzu Chien ◽  
Chih-Hsiung Lai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Lynch Syndrome ◽  
Dna Repair Genes ◽  
Repair Genes

POLYMORPHISMS OF BIOTRANSFORMATION AND DNA REPAIR GENES, DIETARY AND RISK OF COLORECTAL CANCER IN TAIWAN

Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S150
Author(s):  
Chih-Ching Yeh ◽  
Fung-Chang Sung ◽  
Reiping Tang ◽  
Chung Rong Chang-Chieh ◽  
Ling-Ling Hsieh
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Dna Repair Genes ◽  
Repair Genes

Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients

Apmis ◽  
2016 ◽  
Vol 124 (9) ◽  
pp. 736-740 ◽  
Author(s):  
Jan Dimberg ◽  
Marita Skarstedt ◽  
Renate Slind Olsen ◽  
Roland E. Andersson ◽  
Andreas Matussek
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Gene Polymorphism ◽  
Dna Repair Genes ◽  
Repair Genes

Mutations in DNA Repair Genes and Clinical Outcomes of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin or Irinotecan-containing Regimens

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Eric I. Marks ◽  
Robert Matera ◽  
Adam J. Olszewski ◽  
Evgeny Yakirevich ◽  
Wafik S. El-Deiry ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Metastatic Colorectal Cancer ◽  
Clinical Outcomes ◽  
Dna Repair Genes ◽  
Repair Genes

scholarly journals Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer

Biomedicines ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 215
Author(s):  
Matthias Schaks ◽  
Kristina Allgoewer ◽  
Nina Nelson ◽  
Patrick Ehm ◽  
Asmus Heumann ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Repair ◽  
Microsatellite Instability ◽  
Tissue Microarray ◽  
Ectopic Expression ◽  
Strong Relationship ◽  
Cancer Tissue ◽  
Beta Catenin ◽  
Dna Repair Genes ◽  
Repair Genes

Colorectal cancer (CRC) is a heterogeneous disease that results from the accumulation of mutations in colonic mucosa cells. A subclass of CRC is characterized by microsatellite instability, which is thought to occur mainly through inactivation of the DNA mismatch repair genes MLH1 and MSH2. The inositol 5-phosphatase SHIP1 is expressed predominantly in hematopoietic cells. In this study, the expression of SHIP1 in carcinomas and its putative correlation with clinicopathologic parameters, expression of DNA repair genes and microsatellite instability was investigated. By analyzing a multi-tumor tissue microarray, expression of SHIP1 was detected in 48 out of 72 cancer entities analyzed. The expression of SHIP1 protein of 145 kDa was confirmed by Western blot analysis in 7 out of 14 carcinoma cell lines. Analysis of a large colorectal cancer tissue microarray with 1009 specimens revealed SHIP1 expression in 62% of the samples analyzed. SHIP1 expression was inversely correlated with lymph node metastasis, vascular invasion and tumor grade, and it was positively associated with left-sided tumor localization. Interestingly, a strong relationship between the expression of SHIP1 and nuclear and membranous beta-catenin and the DNA repair genes MLH1 and MSH2 was observed.

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