scholarly journals Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo‐optico‐neuropathy (SMON)

2021 ◽  
Author(s):  
Hideki Matsumoto ◽  
Hideo Sasai ◽  
Norio Kawamoto ◽  
Masato Katsuyama ◽  
Makoto Minamiyama ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Japanese Population

scholarly journals Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population

Eye ◽  
2013 ◽  
Vol 27 (8) ◽  
pp. 979-983 ◽  
Author(s):  
T Kato ◽  
A Meguro ◽  
E Nomura ◽  
R Uemoto ◽  
N Nomura ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Variants ◽  
Japanese Population ◽  
Normal Tension Glaucoma

scholarly journals Validation of the Association of Genetic Variants on Chromosome 9p21 and 1q41 With Myocardial Infarction in a Japanese Population

2008 ◽  
Vol 72 (8) ◽  
pp. 1213-1217 ◽  
Author(s):  
Yumiko Hiura ◽  
Yasue Fukushima ◽  
Miyuki Yuno ◽  
Hiromi Sawamura ◽  
Yoshihiro Kokubo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Genetic Variants ◽  
Japanese Population ◽  
Chromosome 9P21

Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population

2017 ◽  
Vol 33 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Lian Liu ◽  
Yusuke Ebana ◽  
Jun-ichi Nitta ◽  
Yoshihide Takahashi ◽  
Shinsuke Miyazaki ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Variants ◽  
Japanese Population

scholarly journals Identification of three genetic variants as novel susceptibility loci for body mass index in a Japanese population

2018 ◽  
Vol 50 (3) ◽  
pp. 179-189 ◽  
Author(s):  
Yoshiki Yasukochi ◽  
Jun Sakuma ◽  
Ichiro Takeuchi ◽  
Kimihiko Kato ◽  
Mitsutoshi Oguri ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Genetic Variants ◽  
Japanese Population ◽  
Association Studies ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Susceptibility Loci ◽  
Cross Sectional ◽  
Japanese Subjects

Recent genome-wide association studies have identified various obesity or metabolic syndrome (MetS) susceptibility loci. However, most studies were conducted in a cross-sectional manner. To address this gap, we performed a longitudinal exome-wide association study to identify susceptibility loci for obesity and MetS in a Japanese population. We traced clinical data of 6,022 Japanese subjects who had annual health check-ups for several years (mean follow-up period, 5 yr) and genotyped ~244,000 genetic variants. The association of single nucleotide polymorphisms (SNPs) with body mass index (BMI) or the prevalence of obesity and MetS was examined in a generalized estimating equation model. Our longitudinal exome-wide association studies detected 21 BMI- and five MetS-associated SNPs (false discovery rate, FDR <0.01). Among these SNPs, 16 have not been previously implicated as determinants of BMI or MetS. Cross-sectional data for obesity- and MetS-related phenotypes in 7,285 Japanese subjects were examined in a replication study. Among the 16 SNPs, three ( rs9491140 , rs145848316 , and rs7863248 ) were related to BMI in the replication cohort ( P < 0.05). In conclusion, three SNPs [ rs9491140 of NKAIN2 (FDR = 0.003, P = 1.9 × 10−5), rs145848316 of KMT2C (FDR = 0.007, P = 4.5 × 10−5), and rs7863248 of AGTPBP1 (FDR = 0.006, P = 4.2 × 10−5)] were newly identified as susceptibility loci for BMI.

scholarly journals Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population

Diabetologia ◽  
2011 ◽  
Vol 54 (12) ◽  
pp. 3071-3077 ◽  
Author(s):  
M. Imamura ◽  
M. Iwata ◽  
H. Maegawa ◽  
H. Watada ◽  
H. Hirose ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variants ◽  
Japanese Population

Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population

Helicobacter ◽  
2010 ◽  
Vol 15 (6) ◽  
pp. 524-531 ◽  
Author(s):  
Masaaki Okubo ◽  
Tomomitsu Tahara ◽  
Tomoyuki Shibata ◽  
Hiromi Yamashita ◽  
Masakatsu Nakamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Japanese Population ◽  
Gastric Cancer Risk ◽  
Common Genetic Variants

Genetic Variants in the SKIV2L Gene in Exudative Age-related Macular Degeneration in the Japanese Population

2014 ◽  
Vol 35 (3) ◽  
pp. 151-155 ◽  
Author(s):  
Seigo Yoneyama ◽  
Yoichi Sakurada ◽  
Fumihiko Mabuchi ◽  
Atsushi Sugiyama ◽  
Takeo Kubota ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Genetic Variants ◽  
Japanese Population ◽  
Age Related Macular Degeneration ◽  
Age Related
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