scholarly journals Vitamin D status and CYP27B 1‐1260 promoter polymorphism in Tunisian patients with systemic lupus erythematosus

2021 ◽  
Author(s):  
Raouia Fakhfakh ◽  
Sawsan Feki ◽  
Aida Elleuch ◽  
Manel Neifar ◽  
Sameh Marzouk ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Promoter Polymorphism ◽  
Vitamin D Status ◽  
Systemic Lupus ◽  
Tunisian Patients

Vitamin D status in Egyptian patients with juvenile-onset systemic lupus erythematosus

2015 ◽  
Vol 35 (9) ◽  
pp. 1535-1540 ◽  
Author(s):  
Kamal El Garf ◽  
Huda Marzouk ◽  
Yomna Farag ◽  
Laila Rasheed ◽  
Ayman El Garf
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Vitamin D Status ◽  
Systemic Lupus ◽  
Juvenile Onset ◽  
Egyptian Patients ◽  
Onset Systemic Lupus Erythematosus

scholarly journals Role of Vitamin D in Systemic Lupus Erythematosus

2014 ◽  
Vol 2 (4) ◽  
pp. 662-667 ◽  
Author(s):  
Rada Miskovic ◽  
Aleksandra Plavsic ◽  
Jasna Bolpacic ◽  
Sanvila Raskovic ◽  
Mirjana Bogic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Animal Studies ◽  
Potential Role ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Systemic Lupus

Vitamin D is a steroid hormone that in addition to its well known role in the metabolism of calcium and phosphorus exerts immunoregulatory properties. Data from animal studies and from prospective clinical trials on patients with rheumatoid arthritis, multiple sclerosis and type 1 diabetes point to the potential role of vitamin D as important environmental factor in the development of autoimmune diseases. Such role of vitamin D in systemic lupus erythematosus (SLE) has not yet been sufficiently studied. This review shows the sources, metabolism and mechanism of action of vitamin D, its effect on the cells of the immune system, prevalence and causes of vitamin D deficiency in patients with SLE, the link between vitamin D status and disease activity as well as recommendations for vitamin D supplementation.

Vitamin D status in systemic lupus erythematosus patients and its association with selected clinical and laboratory parameters

Lupus ◽  
2011 ◽  
Vol 21 (5) ◽  
pp. 477-484 ◽  
Author(s):  
J Bogaczewicz ◽  
A Sysa-Jedrzejowska ◽  
C Arkuszewska ◽  
J Zabek ◽  
E Kontny ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Vitamin D Status ◽  
Systemic Lupus ◽  
Laboratory Parameters

scholarly journals Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review

2017 ◽  
Vol 16 (11) ◽  
pp. 1155-1159 ◽  
Author(s):  
Tarek Carlos Salman-Monte ◽  
Vicenç Torrente-Segarra ◽  
Ana Leticia Vega-Vidal ◽  
Patricia Corzo ◽  
F. Castro-Dominguez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Bone Mineral ◽  
Lupus Erythematosus ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Systemic Lupus

scholarly journals An evaluation of vitamin D status in individuals with systemic lupus erythematosus

2011 ◽  
Vol 70 (4) ◽  
pp. 399-407 ◽  
Author(s):  
Leanne C. Breslin ◽  
Pamela J. Magee ◽  
Julie M. W. Wallace ◽  
Emeir M. McSorley
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Additional Stress ◽  
Vitamin D Status ◽  
Systemic Lupus ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
25 Hydroxyvitamin D

Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease where genetic susceptibility coupled with largely undefined environmental factors is reported to underlie the aetiology of the disease. One such factor is low vitamin D status. The primary source of vitamin D is endogenous synthesis following exposure of the skin to UVB light. Photosensitivity, sunlight avoidance and the use of sun protection factor in combination with medications prescribed to treat the symptoms of the disease, puts SLE patients at increased risk of vitamin D deficiency. Decreased conversion of 25-hydroxyvitamin D to the metabolically active form, 1,25-dihydroxyvitamin D3, is possible, due to renal impairment common in SLE putting additional stress on vitamin D metabolism. The majority of studies have identified low 25-hydroxyvitamin D in SLE patients, albeit using varying cut-offs (<25 to <80 nmol/l). Of these studies, fifteen have investigated a link between status and disease activity with conflicting results. Variation with disease activity index measures used alongside methodological limitations within the study design may partially explain these findings. This review discusses the importance of optimal vitamin D status in SLE, critically evaluates research carried out to date that has investigated vitamin D in SLE, and highlights the need for a well-designed observational study that controls for diet, medication use, dietary supplements, UV exposure and seasonality, that uses sensitive methods for measuring vitamin D status and disease activity in SLE to conclusively establish the role of vitamin D in SLE.

Sign in / Sign up

Export Citation Format

Share Document