scholarly journals Variable degree of mosaicism for tetrasomy 18p in phenotypically discordant monozygotic twins—Diagnostic implications

2020 ◽  
Author(s):  
Małgorzata Rydzanicz ◽  
Pawel Olszewski ◽  
Darek Kedra ◽  
Hanna Davies ◽  
Natalia Filipowicz ◽  
...  
Keyword(s):  
Monozygotic Twins ◽  
Variable Degree ◽  
Tetrasomy 18P

Carotid endarterectomy in patients with foetal-type posterior circle of Willis: Is there an indication for local anaesthesia?

VASA ◽  
2011 ◽  
Vol 40 (5) ◽  
pp. 404-407
Author(s):  
Maras ◽  
Tzormpatzoglou ◽  
Papas ◽  
Papanas ◽  
Kotsikoris ◽  
...  
Keyword(s):  
Carotid Endarterectomy ◽  
Local Anaesthesia ◽  
Anatomical Variation ◽  
Anatomical Variations ◽  
Circle Of Willis ◽  
Variable Degree ◽  
Operative Complications ◽  
The Right ◽  
Ica Stenosis ◽  
Symptomatic Stenosis

Foetal-type posterior circle of Willis is a common anatomical variation with a variable degree of vessel asymmetry. In patients with this abnormality, carotid endarterectomy (CEA) may create cerebral hypo-perfusion intraoperatively, and this may be underestimated under general anaesthesia. There is currently no evidence that anatomical variations in the circle of Willis represent an independent risk factor for stroke. Moreover, there is a paucity of data on treating patients with such anatomical variations and co-existing ICA stenosis. We present a case of CEA under local anaesthesia (LA) in a 52-year-old female patient with symptomatic stenosis of the right ICA and coexistent foetal-type posterior circle of Willis. There were no post-operative complications and she was discharged free from symptoms. She was seen again 3 months later and was free from complications. This case higlights that LA should be strongly considered to enable better intra-operative neurological monitoring in the event of foetal-type posterior circle of Willis.

Abnormal Structure of von Willebrand Factor in Myeloproliferative Syndrome Is Associated to Either Thrombotic or Bleeding Diathesis

1987 ◽  
Vol 58 (02) ◽  
pp. 753-757 ◽  
Author(s):  
M F López-Fernández ◽  
C López-Berges ◽  
R Martín ◽  
A Pardo ◽  
F J Ramos ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Proteinase Inhibitors ◽  
Relative Proportion ◽  
Variable Degree ◽  
Bleeding Diathesis ◽  
Myeloproliferative Syndrome ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryThe multimeric and subunit patterns of plasma von Willebrand factor (vWF) were analyzed in eight patients with myeloproliferative syndrome (MS) in order to investigate the possible existence of heterogeneity in the “in vivo” proteolytic cleavage of the protein, previously observed in this entity. Six patients lacked large vWF multimers, five of them having normal bleeding times (BT) and clinically documented episodes of thrombotic origin, whereas one patient had long BT and bleeding symptoms. Seven patients showed a relative increase in the 176 kDa subunit fragment while the 189 kDa polypeptide was increased in only one. In addition, another patient (and prior to any therapy) showed the presence of a new fragment of approximately 95 kDa which disappeared after Busulfan therapy. The collection of blood from these patients with proteinase inhibitors did not correct the abnormalities.The infusion of DDAVP to two patients with abnormal vWF was accompanied by: the appearance of larger vWF multimers which disappeared rapidly from plasma; an increase in the relative proportion of the satellite bands of each multimer and a further increase of the 176 kDa fragment. These data point to some heterogeneity in the vWF abnormality present in MS which may be related in part to a variable degree of proteolysis of vWF occurring “in vivo” rather than “in vitro”, and which may be associated to either a thrombotic or a bleeding diathesis. They also suggest that despite the presence of abnormal, already proteolyzed vWF, DDAVP-enhanced proteolysis occurs in MS to a similar extent to what is described in normal individuals.

Folie à deux in monozygotic twins with cerebral palsy

2014 ◽  
pp. 1-10 ◽  
Author(s):  
Dimitry Francois ◽  
Evan Bander ◽  
Mark D'Agostino ◽  
Alec Swinburne ◽  
Lauren Broderick ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Monozygotic Twins ◽  
Folie À Deux ◽  
Folie A Deux

Some Views on Current Concerns About Pesticides

2020 ◽  
Vol 31 (5) ◽  
pp. 230-235
Author(s):  
Graham Matthews
Keyword(s):  
Green Revolution ◽  
Scientific Data ◽  
Second World War ◽  
Variable Degree ◽  
World War ◽  
Adverse Impacts ◽  
Current Concerns ◽  
Second World

There is little doubt that the introduction of modern pesticides since the end of the Second World War has enabled a significant increase in the production of many crops during the green revolution, but criticism of the use of pesticides has increased because more people are claiming that their use has resulted in unacceptable adverse impacts on the health of those applying the pesticides or who live near treated farms, as well as more general impacts on the environment. When these modern pesticides were first introduced, countries established registration requirements. These were based on scientific data at that time concerning their toxicity and persistence in the environment, and have been followed to a variable degree, depending on whether individual countries or regions had adequate facilities to assess the data presented by manufacturers.

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