scholarly journals Gene mutations associated with early onset familial Alzheimer’s disease in China: An overview and current status

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Qi Qin ◽  
Yunsi Yin ◽  
Yan Wang ◽  
Yuanyuan Lu ◽  
Yi Tang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Gene Mutations ◽  
Current Status ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease

Nongenetic Factors as Modifiers of the Age of Onset of Familial Alzheimer's Disease

2003 ◽  
Vol 15 (4) ◽  
pp. 337-349 ◽  
Author(s):  
Silvia Mejía ◽  
Margarita Giraldo ◽  
David Pineda ◽  
Alfredo Ardila ◽  
Francisco Lopera
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Logistic Regression ◽  
Early Onset ◽  
Age Of Onset ◽  
Univariate Analysis ◽  
Personal Factors ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease ◽  
High Level

Objective: The purpose of this research was to identify environmental and personal factors that could be related to the variability in the age of onset of familial Alzheimer's disease (FAD) (36–62 years). Methods: A sample was taken of 49 subjects with FAD and with the mutation E280A in the presenilin-1 gene on chromosome 14; the sample was divided into two subgroups: 27 individuals with age of onset of the disease between 36 and 46 years (early onset) and 22 individuals whose disease began between 47 and 62 years (late onset). Information on environmental and personal factors was collected by means of a questionnaire answered by the patients if their clinical condition allowed it, or by their relatives; such information was organized in a categorical way. Comparisons between the two groups for each categorical variable were done by means of the chi-square test. Noncollinear variables that showed statistical significance were included as independent variables in a logistic regression analysis to predict their association with early onset of the disease. Results: Only 5 of the 140 studied variables were different between the two groups in univariate analysis: education, surgical history, type of stressful event, depression, and affective losses. The logistic regression model was constituted by education, depression, and affective losses. High-level education had approximately 15 times more probability of association with an early onset of the disease; both the history of affective losses and depressive symptoms had 4 times more probability of a similar association. Conclusions: The association of high-level education and early onset of the disease could be related to an earlier detection of symptoms, in turn determined by greater intellectual and environmental demands. The occurrence of depression and affective losses has been considered a prodromic manifestation of the disease. Our findings are evidence of high clinical heterogeneity even in a genetically homogeneous group.

The Effects of Gene Mutations on Default Mode Network in Familial Alzheimer’s Disease

2017 ◽  
Vol 56 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Xiaozhen Li ◽  
Eric Westman ◽  
Steinunn Thordardottir ◽  
Anne Kinhult Ståhlbom ◽  
Ove Almkvist ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Default Mode Network ◽  
Gene Mutations ◽  
Familial Alzheimer’S Disease ◽  
Default Mode ◽  
Familial Alzheimer's Disease

scholarly journals Brain Expression of Presenilins in Sporadic and Early-onset, Familial Alzheimer’s Disease

2000 ◽  
Vol 6 (10) ◽  
pp. 878-891 ◽  
Author(s):  
Paul M. Mathews ◽  
Anne M. Cataldo ◽  
Benjamin H. Kao ◽  
Anna G. Rudnicki ◽  
Xi Qin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Familial Alzheimer’S Disease ◽  
Brain Expression ◽  
Familial Alzheimer's Disease

P4-099: Early-onset familial Alzheimer's disease and the definition of family: Experience with an indigenous community

2012 ◽  
Vol 8 (4S_Part_18) ◽  
pp. P667-P667
Author(s):  
Jennifer Mackie ◽  
Elana Brief ◽  
Rachel Butler ◽  
Emily Dwosh ◽  
B. Lynn Beattie ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Indigenous Community ◽  
Familial Alzheimer’S Disease ◽  
Family Experience ◽  
Familial Alzheimer's Disease ◽  
Definition Of
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