scholarly journals Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

2020 ◽  
Vol 8 (10) ◽  
Author(s):  
Alejandra Garcia‐Orozco ◽  
Itzel Alejandra Martinez‐Magaña ◽  
Annie Riera‐Leal ◽  
José Francisco Muñoz‐Valle ◽  
Marco Alonso Martinez‐Guzman ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Disease Susceptibility ◽  
Inhibitory Factor ◽  
Western Mexico ◽  
Macrophage Inhibitory Factor

scholarly journals Single-nucleotide polymorphism and haplotype analysis of macrophage migration inhibitory factor gene and its correlation with serum macrophage migration inhibitory factor levels in North Indian psoriatic patients with moderate disease severity: A cross-sectional study

2021 ◽  
Vol 0 ◽  
pp. 1-7
Author(s):  
Seema Chhabra ◽  
Nirmalya Banerjee ◽  
Tarun Narang ◽  
Swati Sood ◽  
Anuradha Bishnoi ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Migration Inhibitory Factor ◽  
Gene Polymorphisms ◽  
Macrophage Migration Inhibitory Factor ◽  
Disease Susceptibility ◽  
Age At Onset ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Background: Psoriasis is associated with significant morbidity and impaired quality of life. Identification of the host genes that influence disease susceptibility and can potentially guide future, targeted therapy is the need of the hour. Aims: The aim of the study was to investigate the associations of macrophage migration inhibitory factor (MIF) gene polymorphisms, that is, a 5–8-CATT tetra nucleotide repeats at -794 (-794*CATT5–8) and a single-nucleotide polymorphism at -173 (-173*G/C) with the risk of chronic plaque psoriasis and to observe the correlation, if any, of disease determinants with genetic functional variants and circulating MIF levels. Methods: Five hundred and seventeen individuals (265 psoriasis patients and 252 controls) were genotyped for MIF gene polymorphisms. Data were analyzed with respect to disease susceptibility, serum MIF levels, disease severity, age at onset, disease duration and presence of comorbidities. Results: The presence of co-morbidities was more frequently noted in patients with late onset disease (P = 0.01). No statistically significant differences were observed either in genotype (P = 0.680) or allele frequency (P = 0.69) with respect to distribution of MIF-173*G/C polymorphism between patients and controls. The frequencies of genotypes -794*CATT 5/7 and 7/7 were significantly lower in patients (P = 0.027* and 0.038*, respectively). CATT*5/MIF-173*C haplotype occurred at a higher frequency in patients (odds ratio 3.03, 95% confidence intervals 1.09–8.47, P = 0.02). The mean serum MIF levels were significantly higher in patients as compared to controls (P < 0.001). The presence of either extended MIF -794*CATT repeats or C allele did not reveal any significant association with serum MIF levels or age at onset. Analysis of effect of various disease determinants revealed no significant association with genetic variants and serum MIF levels. Limitations: The lesional expression of MIF could not be studied. Conclusion: Our results showed that CATT*5/MIF-173*C haplotype is associated with increased susceptibility to psoriasis vulgaris.

Heat-shock protein 70-1 and HLA class II gene polymorphisms associated with celiac disease susceptibility in Navarra (Spain)

2001 ◽  
Vol 62 (8) ◽  
pp. 821-825 ◽  
Author(s):  
Marı́a A Ramos-Arroyo ◽  
Esperanza Feijoó ◽  
Félix Sánchez-Valverde ◽  
Erkuden Aranburu ◽  
Nieves Irisarri ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Gene Polymorphisms ◽  
Disease Susceptibility ◽  
Class Ii ◽  
Hla Class Ii

scholarly journals Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females

Oncotarget ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 13166-13173 ◽  
Author(s):  
Yu-Xiao Sun ◽  
Chuan-Yu Gao ◽  
Yang Lu ◽  
Xin Fu ◽  
Jun-Ge Jia ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Gene Polymorphisms ◽  
Disease Susceptibility ◽  
Chinese Han ◽  
Males And Females

scholarly journals Study of Association of CD40-CD154 Gene Polymorphisms with Disease Susceptibility and Cardiovascular Risk in Spanish Rheumatoid Arthritis Patients

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49214 ◽  
Author(s):  
Mercedes García-Bermúdez ◽  
Carlos González-Juanatey ◽  
Raquel López-Mejías ◽  
María Teruel ◽  
Alfonso Corrales ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Risk ◽  
Gene Polymorphisms ◽  
Disease Susceptibility

Fractionation of murine macrophage inhibitory factor into two distinct species

1981 ◽  
Vol 63 (1) ◽  
pp. 198-202 ◽  
Author(s):  
Daniel Bout ◽  
Alice L. Kühner ◽  
Volker Klimetzek ◽  
Heinz G. Remold ◽  
John R. David
Keyword(s):  
Distinct Species ◽  
Inhibitory Factor ◽  
Murine Macrophage ◽  
Macrophage Inhibitory Factor
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