scholarly journals Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

2022 ◽  
Author(s):  
Zhangfeng Zhong ◽  
Chi Teng Vong ◽  
Feiyu Chen ◽  
Horyue Tan ◽  
Cheng Zhang ◽  
...  
Keyword(s):  
Natural Products ◽  
Herbal Medicines ◽  
Immune Checkpoints ◽  
Multiple Targets ◽  
Immunomodulatory Potential ◽  
Fight Against Cancer

scholarly journals In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 216
Author(s):  
Nadia A. Rivero-Segura ◽  
Juan C. Gomez-Verjan
Keyword(s):  
Natural Products ◽  
In Silico ◽  
Herbal Medicines ◽  
In Silico Screening ◽  
Docking Analysis ◽  
Physiologically Based Pharmacokinetic ◽  
Important Challenge ◽  
Emodin Anthrone ◽  
Therapeutic Tools ◽  
Vaccine Distribution

The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools.

scholarly journals Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-26 ◽  
Author(s):  
Chen-Yi Liao ◽  
Ching-Chang Lee ◽  
Chi-chang Tsai ◽  
Chao-Wen Hsueh ◽  
Chih-Chiang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Products ◽  
Multidrug Resistance ◽  
Intracellular Signaling ◽  
Poor Prognosis ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Chemopreventive Agents ◽  
Intracellular Signaling Pathways ◽  
Anticancer Effects

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.

scholarly journals SOME ETHNO-MEDICINAL PLANTS AND ECO-FRIENDLY NATURAL COLORS YIELDING FLOWERING PLANTS OF B.S.N. GOVT. P.G. COLLEGE CAMPUS, SHAJAPUR (M.P.) – A SURVEY REPORT

2015 ◽  
Vol 3 (4) ◽  
pp. 1-6
Author(s):  
BodaneArun Kumar
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Flowering Plants ◽  
College Campus ◽  
Medicinal Uses ◽  
Survey Report

The present work is attempt has been made to compile the some ethno-medicinal plants and eco-friendly natural colors yielding flowering plants their preparations used for cure of diseases and information of flowering plants with the list of plants from B.S.N. Govt. P.G. College campus Shajapur, India. The present study focused on some important plants having medicinal uses and color yielding potential. Now-a-days natural products and herbal medicines have been recommended for the treatment of various diseases. The present study of ethno-medicinal and natural colors yielding flowering plants is helpful for local peoples of Shajapur.

scholarly journals Natural products as inhibitors of COVID-19 main protease – A virtual screening by molecular docking

2020 ◽  
Author(s):  
Marzieh omrani ◽  
Mohammad Bayati ◽  
Parvaneh Mehrbod ◽  
Samad Nejad-Ebrahimi
Keyword(s):  
Natural Products ◽  
Virtual Screening ◽  
High Throughput ◽  
Herbal Medicines ◽  
Respiratory Illness ◽  
Fast Method ◽  
Main Protease ◽  
Glide Docking ◽  
Adme Properties ◽  
High Throughput Virtual Screening

Abstract Background: The novel coronavirus (2019-nCoV) causes a severe respiratory illness that was unknown in the human before. Its alarmingly quick transmission to many countries across the world resulted in a worldwide health emergency. It has caused a notable percentage of morbidity and mortality. Therefore, an imminent need for drugs to combat this disease has been increased. Global collaborative efforts from scientists are underway to find a therapy to treat infections and reduce death cases. Herbal medicines and purified natural products have been reported to have antiviral activity against Coronaviruses (CoVs).Methods: In this study, a High Throughput Virtual Screening (HTVS) protocol was used as a fast method on the discovery of novel drug candidates as the COVID-19 main protease inhibitors. Over 180,000 natural product-based compounds were obtained from the ZINC database and virtually screened against the COVID-19 main protease. In this study, the Glide docking program was applied for high throughput virtual screening. Extra precision (XP) and in a combination of Prime module, induced-fit docking (IFD) approach was also used. Additionally, the ADME properties of all compounds were analyzed, and the final selection was carried out based on the Lipinski rule of five. Results: The nineteen compounds were selected and introduced as new potential inhibitors. The compound ZINC08765174 (1-[3-(1H-indol-3-yl) propanoyl]-N-(4-phenylbutan-2-yl)piperidine-3-carboxamide) showed a strong binding affinity (-11.5 kcal/mol) to the crucial residues of COVID-19 main protease comparing to peramivir (-9.8 kcal/mol) as a positive control.Conclusions: The excellent ADME properties proposed the opportunity of this compound to be a promising candidate for the treatment of COVID-19.

scholarly journals Effect of Herbal Medicinal Compounds on Alzheimer’s Disease Pathology in APP/PS1 Transgenic Mouse Model

2020 ◽  
Vol 15 (8) ◽  
pp. 1934578X2094898
Author(s):  
Xuexia Li ◽  
Zhijun He ◽  
Chao Wang ◽  
Yanjun Liu ◽  
Zhifu Shan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Herbal Medicines ◽  
Protective Effects ◽  
Multiple Targets ◽  
Aβ Oligomers ◽  
Protein Levels ◽  
Medicinal Compounds ◽  
Single Target ◽  
Herbal Medicinal

The pathogenesis of Alzheimer’s disease (AD) is complex as various mechanisms interact with each other and, therefore, intervention from a single target is often ineffective. Many studies have shown that herbal medicines, such as curcumin, fisetin, icariin, and ginsenosides, have significant intervention effects on AD with different treatment mechanisms. Therefore, we have designed this study to know whether the combination of these herbal medicines can have an intervention effect on AD through multiple targets. Amyloid precursor protein/presenilin 1(APP/PS1) double transgenic AD mice were used to study the protective effects of a combination of curcumin, piperine, icariin, and ginsenosides, as well as a combination of fisetin, piperine, icariin, and ginsenosides, which were separately mixed into the feed. These herbal medicinal compounds (HMCs) lowered the serum lipid levels, reduced the Aβ oligomers, decreased the pS404-tau protein, as well as neurofibrillary tangles, and restored the reduction of synaptic protein levels and neuronal death of AD mice without causing toxicity to liver and kidneys. In this study, we found that HMCs have significant intervention against AD through multiple targets, providing a novel therapeutic idea for the prevention of AD.

scholarly journals Natural remedies for acute post-viral cough in children

2021 ◽  
Vol 49 (3) ◽  
pp. 173-184
Author(s):  
Vitalia Murgia ◽  
Giorgio Ciprandi ◽  
Martina Votto ◽  
Maria De Filippo ◽  
Maria Angela Tosca ◽  
...  
Keyword(s):  
Natural Products ◽  
Herbal Medicines ◽  
Childhood And Adolescence ◽  
Common Symptom ◽  
Efficacy And Safety ◽  
Acute Cough ◽  
Randomized Controlled ◽  
Pelargonium Sidoides ◽  
Natural Remedies ◽  
Robust Evidence

The post-viral acute cough is the most common symptom in childhood. Consequently, the use of cough relievers is frequent. Many products for treating cough contain natural compo-nents. An ancient tradition has always established herbal medicine and honey as effective and safe means to relieve cough. Nevertheless, very few studies adequately investigated the real effectiveness and safety of natural products in treating acute cough. There is some evidence, provided by pediatric randomized controlled trials, about honey, one multicomponent product (containing Plantagolanceolata, Grindelia robusta, Helichrysum italicum, and honey), and Pelargonium sidoides. Other group of substances, including glycerol and isolated natural compounds, can help manage cough but robust evidence still lacks in children. There is an urgent need to perform rigorous studies that confirm the natural products’ efficacy and safety for relieving post-viral acute cough.Key points: Acute post-viral cough is prevalent in childhood and adolescence. There is a grow-ing interest concerning the use of natural remedies for post-viral cough. Many herbal medicines could be used satisfactorily for this issue.

scholarly journals Natural AMPK Activators in Cardiovascular Disease Prevention

2022 ◽  
Vol 12 ◽  
Author(s):  
Reza Heidary Moghaddam ◽  
Zeinab Samimi ◽  
Sedigheh Asgary ◽  
Pantea Mohammadi ◽  
Soroush Hozeifi ◽  
...  
Keyword(s):  
Natural Products ◽  
Herbal Medicines ◽  
Relevant Information ◽  
Ampk Signaling ◽  
Cardiometabolic Disorders ◽  
Regulatory Effects ◽  
Therapeutic Tools ◽  
Novel Therapeutic Strategies ◽  
Cardiovascular Therapeutics

Cardiovascular diseases (CVD), as a life-threatening global disease, is receiving worldwide attention. Seeking novel therapeutic strategies and agents is of utmost importance to curb CVD. AMP-activated protein kinase (AMPK) activators derived from natural products are promising agents for cardiovascular drug development owning to regulatory effects on physiological processes and diverse cardiometabolic disorders. In the past decade, different therapeutic agents from natural products and herbal medicines have been explored as good templates of AMPK activators. Hereby, we overviewed the role of AMPK signaling in the cardiovascular system, as well as evidence implicating AMPK activators as potential therapeutic tools. In the present review, efforts have been made to compile and update relevant information from both preclinical and clinical studies, which investigated the role of natural products as AMPK activators in cardiovascular therapeutics.

scholarly journals Overview of Viral Pneumonia Associated With Influenza Virus, Respiratory Syncytial Virus, and Coronavirus, and Therapeutics Based on Natural Products of Medicinal Plants

2021 ◽  
Vol 12 ◽  
Author(s):  
Ziwei Hu ◽  
Jinhong Lin ◽  
Jintao Chen ◽  
Tengxi Cai ◽  
Lixin Xia ◽  
...  
Keyword(s):  
Natural Products ◽  
Influenza Virus ◽  
Medicinal Plants ◽  
Respiratory Virus ◽  
Herbal Medicines ◽  
Viral Pneumonia ◽  
Screening Tools ◽  
Current Status ◽  
Clinical Effects ◽  
Syncytial Virus

Viral pneumonia has been a serious threat to global health, especially now we have dramatic challenges such as the COVID-19 pandemic. Approximately six million cases of community-acquired pneumonia occur every year, and over 20% of which need hospital admission. Influenza virus, respiratory virus, and coronavirus are the noteworthy causative agents to be investigated based on recent clinical research. Currently, anaphylactic reaction and inflammation induced by antiviral immunity can be incriminated as causative factors for clinicopathological symptoms of viral pneumonia. In this article, we illustrate the structure and related infection mechanisms of these viruses and the current status of antiviral therapies. Owing to a set of antiviral regiments with unsatisfactory clinical effects resulting from side effects, genetic mutation, and growing incidence of resistance, much attention has been paid on medicinal plants as a natural source of antiviral agents. Previous research mainly referred to herbal medicines and plant extracts with curative effects on viral infection models of influenza virus, respiratory virus, and coronavirus. This review summarizes the results of antiviral activities of various medicinal plants and their isolated substances, exclusively focusing on natural products for the treatment of the three types of pathogens that elicit pneumonia. Furthermore, we have introduced several useful screening tools to develop antiviral lead compounds.

scholarly journals Natural products as inhibitors of COVID-19 main protease–A virtual screening by molecular docking

2021 ◽  
Author(s):  
Marzieh Omrani ◽  
Mohammad Bayati ◽  
Parvaneh Mehrbod ◽  
Kamal Asmari Bardazard ◽  
Samad Nejad-Ebrahimi
Keyword(s):  
Natural Products ◽  
Virtual Screening ◽  
High Throughput ◽  
Herbal Medicines ◽  
Respiratory Illness ◽  
Fast Method ◽  
Main Protease ◽  
Glide Docking ◽  
Adme Properties ◽  
High Throughput Virtual Screening

Background: The novel coronavirus (2019-nCoV) causes a severe respiratory illness unknown to a human before. Its alarmingly quick transmission to many countries across the world has resulted in a global health emergency. Therefore, an imminent need for drugs to combat this disease has been increased. Worldwide collaborative efforts from scientists are underway to determine a therapy to treat COVID-19 infections and reduce mortality rates. Since herbal medicines and purified natural products have been reported to have antiviral activity against Coronaviruses (CoVs), this in silico evaluation was performed for identifying potential natural compounds with promising inhibitory activities against COVID-19. Methods: In this study, a High Throughput Virtual Screening (HTVS) protocol was used as a fast method for discovering novel drug candidates as potential COVID-19 main protease (Mpro) inhibitors. Over 180,000 natural product-based compounds were obtained from the ZINC database and virtually screened against the COVID-19 Mpro. In this study, the Glide docking program was applied for high throughput virtual screening. Also, Extra precision (XP) has been used following the induced-fit docking (IFD) approach. The ADME properties of all compounds were analyzed and a final selection was made based on the Lipinski rule of five. Also, molecular dynamics (MD) simulations were conducted for a virtual complex of the best scoring compound with COVID-19 protease. Results: Nineteen compounds were introduced as new potential inhibitors. Compound ZINC08765174 (1-[3-(1H-indol-3-yl) propanoyl]-N-(4-phenylbutan-2-yl)piperidine-3-carboxamide showed a strong binding affinity (-11.5 kcal/mol) to the COVID-19 Mpro comparing to peramivir (-9.8 kcal/mol) as a positive control. Conclusions: Based on these findings, nineteen compounds were proposed as possible new COVID-19 inhibitors, of which ZINC08765174 had a high affinity to Mpro. Furthermore, the promising ADME properties of the selected compounds emphasize their potential as attractive candidates for the treatments of COVID-19.

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