Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

2019 ◽  
Vol 39 (6) ◽  
pp. 2460-2504 ◽  
Author(s):  
Andraž Lamut ◽  
Lucija Peterlin Mašič ◽  
Danijel Kikelj ◽  
Tihomir Tomašič
Keyword(s):  
Efflux Pump ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Efflux Pump Inhibitors

scholarly journals Hospital Wastewater—Important Source of Multidrug Resistant Coliform Bacteria with ESBL-Production

2020 ◽  
Vol 17 (21) ◽  
pp. 7827
Author(s):  
Kristína Lépesová ◽  
Petra Olejníková ◽  
Tomáš Mackuľak ◽  
Klára Cverenkárová ◽  
Monika Krahulcová ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Wastewater Treatment Plants ◽  
Resistance Mechanism ◽  
Multidrug Resistant ◽  
Coliform Bacteria ◽  
Resistant Bacteria ◽  
Hospital Wastewater ◽  
Multidrug Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Extended Spectrum

This work compares the prevalence of antibiotic resistant coliform bacteria in hospital wastewater effluents in Slovak (SR) and Czech Republic (ČR). It also describes selected antibiotic resistant isolates in view of resistance mechanism and virulence factor. The highest number of multidrug resistant bacteria was detected in samples from the hospital in Valašské Meziříčí (ČR). More than half of resistant isolates showed multidrug resistance phenotype as well as strong ability to form biofilm. In 42% of isolates efflux pump overproduction was detected together with tetA and tetE genes. The production of extended-spectrum β-lactamases in coliform isolates was encoded mainly by blaTEM, blaCTX-M-2 and blaCTX-M-8/25 genes. About 62% of resistants contained a combination of two or more extended spectrum beta-lactamases (ESBL) genes. Our results strengthen the fact that hospital effluents are a source of multidrug resistant bacteria which can spread their resistance genes to other bacteria in wastewater treatment plants (WWTPs). Accordingly, hospital wastewater should be better treated before it enters urban sewerage.

C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria

2016 ◽  
Vol 23 (8) ◽  
pp. 738-747 ◽  
Author(s):  
Esteban N. Lorenzón ◽  
Norival A. Santos-Filho ◽  
Matheus A. S. Ramos ◽  
Tais M. Bauab ◽  
Ilana L. B. C. Camargo ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Increased Activity
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