scholarly journals The dual role of thymidine phosphorylase in cancer development and chemotherapy

2009 ◽  
Vol 29 (6) ◽  
pp. 903-953 ◽  
Author(s):  
Annelies Bronckaers ◽  
Federico Gago ◽  
Jan Balzarini ◽  
Sandra Liekens
Keyword(s):  
Thymidine Phosphorylase ◽  
Dual Role ◽  
Cancer Development

ChemInform Abstract: The Dual Role of Thymidine Phosphorylase in Cancer Development and Chemotherapy

ChemInform ◽  
2010 ◽  
Vol 41 (1) ◽  
pp. no-no ◽  
Author(s):  
Annelies Bronckaers ◽  
Federico Gago ◽  
Jan Balzarini ◽  
Sandra Liekens
Keyword(s):  
Thymidine Phosphorylase ◽  
Dual Role ◽  
Cancer Development

scholarly journals The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it

2013 ◽  
Vol 20 (6) ◽  
pp. R341-R356 ◽  
Author(s):  
Rosalinda M Savoy ◽  
Paramita M Ghosh
Keyword(s):  
Tumor Formation ◽  
Dual Role ◽  
Cancer Development ◽  
Vascular Endothelial ◽  
Filamin A ◽  
Invasion And Metastasis ◽  
Promoting Effect ◽  
Metastasis Development ◽  
Endothelial Growth Factor

Filamin A (FlnA) has been associated with actin as cytoskeleton regulator. Recently its role in the cell has come under scrutiny for FlnA's involvement in cancer development. FlnA was originally revealed as a cancer-promoting protein, involved in invasion and metastasis. However, recent studies have also found that under certain conditions, it prevented tumor formation or progression, confusing the precise function of FlnA in cancer development. Here, we try to decipher the role of FlnA in cancer and the implications for its dual role. We propose that differences in subcellular localization of FlnA dictate its role in cancer development. In the cytoplasm, FlnA functions in various growth signaling pathways, such as vascular endothelial growth factor, in addition to being involved in cell migration and adhesion pathways, such as R-Ras and integrin signaling. Involvement in these pathways and various others has shown a correlation between high cytoplasmic FlnA levels and invasive cancers. However, an active cleaved form of FlnA can localize to the nucleus rather than the cytoplasm and its interaction with transcription factors has been linked to a decrease in invasiveness of cancers. Therefore, overexpression of FlnA has a tumor-promoting effect, only when it is localized to the cytoplasm, whereas if FlnA undergoes proteolysis and the resulting C-terminal fragment localizes to the nucleus, it acts to suppress tumor growth and inhibit metastasis. Development of drugs to target FlnA and cause cleavage and subsequent localization to the nucleus could be a new and potent field of research in treating cancer.

scholarly journals A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

Cancer Cell ◽  
2017 ◽  
Vol 32 (3) ◽  
pp. 342-359.e10 ◽  
Author(s):  
Yannick Boege ◽  
Mohsen Malehmir ◽  
Marc E. Healy ◽  
Kira Bettermann ◽  
Anna Lorentzen ◽  
...  
Keyword(s):  
Dna Damage ◽  
Liver Cancer ◽  
Dual Role ◽  
Cancer Development ◽  
Caspase 8

scholarly journals The Dual Role of Autophagy in Crizotinib-Treated ALK+ ALCL: From the Lymphoma Cells Drug Resistance to Their Demise

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2517
Author(s):  
Estelle Espinos ◽  
Raymond Lai ◽  
Sylvie Giuriato
Keyword(s):  
Drug Resistance ◽  
Dual Role ◽  
Cancer Development ◽  
Death Process ◽  
Lymphoma Cells ◽  
Survival Mechanism

Autophagy has been described as harboring a dual role in cancer development and therapy. Depending on the context, it can exert either pro-survival or pro-death functions. Here, we review what is known about autophagy in crizotinib-treated ALK+ ALCL. We first present our main findings on the role and regulation of autophagy in these cells. Then, we provide literature-driven hypotheses that could explain mechanistically the pro-survival properties of autophagy in crizotinib-treated bulk and stem-like ALK+ ALCL cells. Finally, we discuss how the potentiation of autophagy, which occurs with combined therapies (ALK and BCL2 or ALK and RAF1 co-inhibition), could convert it from a survival mechanism to a pro-death process.

Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
A Chatzigeorgiou ◽  
R Garcia-Martin ◽  
KJ Chung ◽  
I Alexaki ◽  
A Klotzsche-von Ameln ◽  
...  
Keyword(s):  
Dual Role ◽  
Alcoholic Steatohepatitis ◽  
Metabolic Dysregulation

A dual role of the N-terminal FQQI motif in GLUT4 trafficking

2008 ◽  
Vol 3 (S 1) ◽  
Author(s):  
U Bernhardt ◽  
HG Joost ◽  
H Al-Hasani
Keyword(s):  
Dual Role

Dual Role of RKIP in NF-kB Signaling Pathways

2011 ◽  
Vol 2 (1) ◽  
pp. 21-34
Author(s):  
Huihui Tang ◽  
Sungdae Park ◽  
Kam C. Yeung
Keyword(s):  
Signaling Pathways ◽  
Dual Role
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