scholarly journals Biodegradable 3D porous zinc alloy scaffold for bone fracture fixation devices

2020 ◽  
Vol 3 (6) ◽  
Author(s):  
M Bobby Kannan ◽  
Jonathon Chappell ◽  
Hadis Khakbaz ◽  
Mehdi Taherishargh ◽  
Thomas Fiedler
Keyword(s):  
Bone Fracture ◽  
Fracture Fixation ◽  
Zinc Alloy ◽  
Fixation Devices

Short-Term In Vivo Response to Anodized Magnesium Alloy as a Biodegradable Material for Bone Fracture Fixation Devices

2021 ◽  
Author(s):  
Julieta L. Merlo ◽  
María R. Katunar ◽  
María Florencia Tano de la Hoz ◽  
Sabrina Carrizo ◽  
Leandro Salemme Alonso ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Bone Fracture ◽  
Fracture Fixation ◽  
Biodegradable Material ◽  
Short Term ◽  
Fixation Devices

scholarly journals UJI BIOKOMPATIBILITAS KOMPOSIT POLIVINIL ALKOHOLHIDROKSIAPATIT DENGAN PENGUAT CATGUT SEBAGAI BAHAN PENYAMBUNG PATAH TULANG

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
M. Taha Ma’ruf, Widowati Siswomihardjo, Marsetyawan HNE Alva Edy Tontowi
Keyword(s):  
Lactic Acid ◽  
Mechanical Strength ◽  
Bone Fracture ◽  
Fracture Fixation ◽  
Wistar Rats ◽  
The Body ◽  
Experimental Animals ◽  
Fixation Devices ◽  
Good Biocompatibility ◽  
All Treatment

Bone fracture fixation devices have been using rigid metallic materials such as titanium, titanium-alloy or cobalt chrome. Besides having some advantages, the titanium fixation devices also have disadvantages, such as too high strength and stiffness. This continuously stimulates the bone, causing bone atrophy under the plate, further disrupting the growth of bones, especially in children. Other deficiencies of this metal material is its sensitivity to temperature changes and the spread of metal ions in several organs. Some of these shortcomings led to the need for a secondary operation. Bone fracture fixation devices, such as the poly-l-lactic acid (PLLA), can be absorbed by the body and show some other advantages. However, it also has some drawbacks due to the high crystalline products during the degradation process. Lactic acid monomer released after degradation causes cellular response at the implant site, which facilitates the release of chemical mediators, such as prostaglandine by fibroblasts and macrophages as a cause of bone resorption. Therefore, this study aimed to develop the use of other polymeric materials that have good biocompatibility,appropriate mechanical strength, and can be absorbed by the body, such as Polyvinyl Alcohol (PVA). Previous research suggests that the PVA-HA composite with catgut reinforcement has sufficient and stable mechanical strength to be used as bone fracture fixation material. The purpose of this study is to know whether the PVA-HA composite with catgut reinforcement has good biocompatibility without toxicity and hypersensitivity effects in experimental animals. Biocompatibility testing includes local cytotoxicity and type IV contact hypersensitivity test. This type of research is experimental in vivo laboratory using wistar rats (Rattus norvegicus). Testing is done through two phases, in which induction or sensitization phase is done by rubbing PVA-HA composite with catgut reinforced ointment powder on the ears that lasts up to 10 days. After being rested for 3 days, this is followed by a second phase contact (elicitation) on day 14 and observed in the period of 24, 48, and 72 hours. Observations were made macroscopically and ear thickness was measured with a micrometer. Local toxicity testing is done by implantation of PVA-HA composite with catgut reinforcement on the back catgut of wistar rats. After a certain time period, the implant material is opened,examined, and observed histologically under a light microscope. The results showed no discoloration or induration on the animal ears in all treatment and control groups, both for the sensitization and the elicitation phase. One way ANOVA statistical test showed that there were no significant differences in the results of measurements of the thickness of the wistar rats ears from all treatment groups before and after treatment on measures 24, 48 and 72 hours (ρ >0.05). Microscopic examination showed no infiltration of acute inflammatory cells such as neutrophils, basophils or eusinofil, and chronic inflammatory cell infiltration such as macrophages, lymphocytes and plasma cells. It can be concluded that the PVA-HA composite with catgut reinforcement is a material that does not cause toxicity and hypersensitivity in experimental animals, thus potentially can be used as bone fractures fixation material. 

Characterization of short-fibre reinforced thermoplastics for fracture fixation devices

Biomaterials ◽  
1990 ◽  
Vol 11 (8) ◽  
pp. 541-547 ◽  
Author(s):  
Stanley A. Brown ◽  
Robert S. Hastings ◽  
Jeffrey J. Mason ◽  
Abdelsamie Moet
Keyword(s):  
Fracture Fixation ◽  
Short Fibre ◽  
Fixation Devices ◽  
Reinforced Thermoplastics

scholarly journals A comparative study on the in vivo degradation of poly(L-lactide) based composite implants for bone fracture fixation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zongliang Wang ◽  
Yu Wang ◽  
Yoshihiro Ito ◽  
Peibiao Zhang ◽  
Xuesi Chen
Keyword(s):  
Comparative Study ◽  
Bone Fracture ◽  
Fracture Fixation ◽  
In Vivo Degradation

Partially biodegradable polyacrylic-polyester composites for internal bone fracture fixation

Biomaterials ◽  
1991 ◽  
Vol 12 (2) ◽  
pp. 236-241 ◽  
Author(s):  
Julio San Román ◽  
Pedro Guillén García
Keyword(s):  
Bone Fracture ◽  
Fracture Fixation ◽  
Polyester Composites

scholarly journals Experimental and numerical investigation into the influence of loading conditions in biomechanical testing of locking plate fracture fixation devices

2018 ◽  
Vol 7 (1) ◽  
pp. 111-120 ◽  
Author(s):  
A. MacLeod ◽  
A. H. R. W. Simpson ◽  
P. Pankaj
Keyword(s):  
Numerical Investigation ◽  
Fracture Fixation ◽  
Computational Models ◽  
Locking Plate ◽  
Biomechanical Testing ◽  
Loading Conditions ◽  
Secondary Fracture ◽  
Plate Fracture ◽  
Fixation Devices ◽  
Working Length

ObjectivesSecondary fracture healing is strongly influenced by the stiffness of the bone-fixator system. Biomechanical tests are extensively used to investigate stiffness and strength of fixation devices. The stiffness values reported in the literature for locked plating, however, vary by three orders of magnitude. The aim of this study was to examine the influence that the method of restraint and load application has on the stiffness produced, the strain distribution within the bone, and the stresses in the implant for locking plate constructs.MethodsSynthetic composite bones were used to evaluate experimentally the influence of four different methods of loading and restraining specimens, all used in recent previous studies. Two plate types and three screw arrangements were also evaluated for each loading scenario. Computational models were also developed and validated using the experimental tests.ResultsThe method of loading was found to affect the gap stiffness strongly (by up to six times) but also the magnitude of the plate stress and the location and magnitude of strains at the bone-screw interface.ConclusionsThis study demonstrates that the method of loading is responsible for much of the difference in reported stiffness values in the literature. It also shows that previous contradictory findings, such as the influence of working length and very large differences in failure loads, can be readily explained by the choice of loading condition. Cite this article: A. MacLeod, A. H. R. W. Simpson, P. Pankaj. Experimental and numerical investigation into the influence of loading conditions in biomechanical testing of locking plate fracture fixation devices. Bone Joint Res 2018;7:111–120. DOI: 10.1302/2046-3758.71.BJR-2017-0074.R2.

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