Longitudinal White Matter Damage Evolution in Parkinson's Disease

2021 ◽  
Author(s):  
Pietro Giuseppe Scamarcia ◽  
Federica Agosta ◽  
Edoardo Gioele Spinelli ◽  
Silvia Basaia ◽  
Tanja Stojković ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Damage Evolution ◽  
White Matter Damage

P4-135: Mild cognitive impairment in Parkinson's disease is associated with white matter damage

2011 ◽  
Vol 7 ◽  
pp. S751-S751
Author(s):  
Elisa Canu ◽  
Federica Agosta ◽  
Lidia Sarro ◽  
Elka Stefanova ◽  
Aleksandra Tomic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Damage

scholarly journals White matter damage and systemic inflammation in Parkinson’s disease

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Pi-Ling Chiang ◽  
Hsiu-Ling Chen ◽  
Cheng-Hsien Lu ◽  
Pei-Chin Chen ◽  
Meng-Hsiang Chen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Systemic Inflammation ◽  
White Matter Damage

scholarly journals Gray and white matter damage are associated with motor symptoms in Parkinson’s disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Mahsa Dadar ◽  
Myrlene Gee ◽  
Simon Duchesne ◽  
Richard Camicioli
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Motor Symptoms ◽  
White Matter Damage

scholarly journals Mild cognitive impairment in Parkinson's disease is associated with a distributed pattern of brain white matter damage

2013 ◽  
Vol 35 (5) ◽  
pp. 1921-1929 ◽  
Author(s):  
Federica Agosta ◽  
Elisa Canu ◽  
Elka Stefanova ◽  
Lidia Sarro ◽  
Aleksandra Tomić ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Damage ◽  
Brain White Matter

IC-P-033: Mild cognitive impairment in Parkinson's disease is associated with white matter damage

2011 ◽  
Vol 7 ◽  
pp. S21-S21
Author(s):  
Elisa Canu ◽  
Federica Agosta ◽  
Lidia Sarro ◽  
Elka Stefanova ◽  
Aleksandra Tomic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Damage

Assessment of White Matter Lesions in Parkinson's Disease: Voxel-based Analysis and Tract-based Spatial Statistics Analysis of Parkinson's Disease with Mild Cognitive Impairment

2020 ◽  
Vol 17 (4) ◽  
pp. 480-486
Author(s):  
Wei Pu ◽  
Xudong Shen ◽  
Mingming Huang ◽  
Zhiqian Li ◽  
Xianchun Zeng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Corpus Callosum ◽  
Fractional Anisotropy ◽  
Spatial Statistics ◽  
Diffusion Tensor ◽  
Tract Based Spatial Statistics

Objective: Application of diffusion tensor imaging (DTI) to explore the changes of FA value in patients with Parkinson's disease (PD) with mild cognitive impairment. Methods: 27 patients with PD were divided into PD with mild cognitive impairment (PD-MCI) group (n = 7) and PD group (n = 20). The original images were processed using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS). Results: The average age of pd-mci group was longer than that of PD group, and the course of disease was longer than that of PD group. Compared with PD group, the voxel based analysis-fractional anisotropy (VBA-FA) values of PD-MCI group decreased in the following areas: bilateral frontal lobe, bilateral temporal lobe, bilateral parietal lobe, bilateral subthalamic nucleus, corpus callosum, and gyrus cingula. Tract-based spatial statistics-fractional anisotropy (TBSS-FA) values in PD-MCI group decreased in bilateral corticospinal tract, anterior cingulum, posterior cingulum, fornix tract, bilateral superior thalamic radiation, corpus callosum(genu, body and splenium), bilateral uncinate fasciculus, bilateral inferior longitudinal fasciculus, bilateral superior longitudinal fasciculus, bilateral superior fronto-occipital fasciculus, bilateral inferior fronto-occipital fasciculus, and bilateral parietal-occipital tracts. The mean age of onset in the PD-MCI group was greater than that in the PD group, and the disease course was longer than that in the PD group. Conclusion: DTI-based VBA and TBSS post-processing methods can detect abnormalities in multiple brain areas and white matter fiber tracts in PD-MCI patients. Impairment of multiple cerebral cortex and white matter fiber pathways may be an important causes of cognitive dysfunction in PD-MCI.

Sign in / Sign up

Export Citation Format

Share Document