Reply to: “Cognitive Impairments in Spinocerebellar Ataxia Type 10 and Their Relation to Cortical Thickness”

2021 ◽  
Vol 36 (12) ◽  
pp. 2977-2977
Author(s):  
Alex T. Meira ◽  
Walter O. Arruda ◽  
Gustavo L. Franklin ◽  
Léo Coutinho ◽  
Giovanna Strobel ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Cortical Thickness ◽  
Cognitive Impairments ◽  
Spinocerebellar Ataxia Type

Cognitive Impairments in Spinocerebellar Ataxia Type 10 and Their Relation to Cortical Thickness

2021 ◽  
Author(s):  
Amanda Chirino‐Pérez ◽  
Israel Vaca‐Palomares ◽  
Diana L. Torres ◽  
Carlos R. Hernandez‐Castillo ◽  
Rosalinda Diaz ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Cortical Thickness ◽  
Cognitive Impairments ◽  
Spinocerebellar Ataxia Type

scholarly journals P14.102 Cerebellar atrophy patterns in paraneoplastic cerebellar degeneraiton and spinocerebellar ataxia 1 (SCA1)

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii92-iii92
Author(s):  
C Vialatte de Pémille ◽  
D Psimaras ◽  
I Adanyegu ◽  
F Graus ◽  
A Dürr ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Cortical Thickness ◽  
Univariate Analysis ◽  
Radiological Finding ◽  
Cerebellar Atrophy ◽  
Specific Pattern ◽  
Cortical Atrophy ◽  
Spinocerebellar Ataxia Type ◽  
Multicentric Study ◽  
Brain Morphometry

Abstract BACKGROUND Brain and more specifically cerebellar atrophy is a major radiological finding in both Paraneoplastic Cerebellar Degeneration (PCD) with anti-Yo antibodies and Spinocerebellar Ataxia type 1 (SCA1).We sought to analyze the different brain volumetric patterns of cerebellar atrophy in these diseases. MATERIAL AND METHODS We performed a retrospective multicentric study (Paris, Lyon, Barcelona reference centres) with either anti-Yo PCD (n=16) or SCA1 (n=17) and 30 healthy subjects paired by age. We used VolBrain and CERES algorithms to obtain the brain and cerebellum segmentation, respectively as well as the cortical thickness. We used a Sparse Canonical Correlation Analysis (SCCAN) and Voxel Brain Morphometry (VBM) with family wise error correction to analyze volumetric differences between the different conditions. RESULTS SCA patients were younger than PCD patients (p<0.05, ANOVA). In univariate analysis, most of the atrophic regions (p<0.05) were common between PCD and SCA1 compared to controls. Isolated cortical thickness and grey matter analysis showed predominant atrophy in PCD patients. Multivariate analysis using SCCAN and VBM confirmed these results. We identified a particular atrophy pattern in PCD patients involving lobules III to VII. We observed a more diffuse atrophy distribution in SCA1 patients and a lower cortical atrophy in PCD patients. CONCLUSION We described the specific pattern of topographic cerebellar atrophy in PCD and SCA1 patients. The cerebellar atrophy in PCD is mainly localized in the neocerebellum.

Reply to: “Further Perspectives on the Neural Bases of Cognitive Impairments in Spinocerebellar Ataxia Type 10”

2021 ◽  
Vol 36 (12) ◽  
pp. 2978-2978
Author(s):  
Amanda Chirino‐Pérez ◽  
Israel Vaca‐Palomares ◽  
Juan Fernandez‐Ruiz
Keyword(s):  
Spinocerebellar Ataxia ◽  
Cognitive Impairments ◽  
Spinocerebellar Ataxia Type ◽  
Neural Bases

Motor and cognitive impairments in spinocerebellar ataxia type 7 and its correlations with cortical volumes

2018 ◽  
Vol 48 (10) ◽  
pp. 3199-3211 ◽  
Author(s):  
Amanda Chirino ◽  
Carlos R. Hernandez‐Castillo ◽  
Victor Galvez ◽  
Anabel Contreras ◽  
Rosalinda Diaz ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Cognitive Impairments ◽  
Spinocerebellar Ataxia Type ◽  
Spinocerebellar Ataxia Type 7

Mitochondrial impairment in patients with spinocerebellar ataxia type 3

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
L Schöls ◽  
J Andrich ◽  
H Przuntek ◽  
K Müller ◽  
J Zange
Keyword(s):  
Spinocerebellar Ataxia ◽  
Spinocerebellar Ataxia Type ◽  
Spinocerebellar Ataxia Type 3 ◽  
Mitochondrial Impairment ◽  
Type 3

Eye hand coordination in spinocerebellar ataxia type 17

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
P Trillenberg ◽  
A Sprenger ◽  
A Hiller ◽  
C Klein ◽  
G Weinberger ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Spinocerebellar Ataxia Type ◽  
Hand Coordination ◽  
Spinocerebellar Ataxia Type 17

Eye movement abnormalities in spinocerebellar ataxia type 17

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
J. Hübner ◽  
A. Sprenger ◽  
J. Hagenah ◽  
C. Klein ◽  
H. Rambold ◽  
...  
Keyword(s):  
Eye Movement ◽  
Spinocerebellar Ataxia ◽  
Spinocerebellar Ataxia Type ◽  
Spinocerebellar Ataxia Type 17

Preserved eye-hand coordination in spinocerebellar ataxia type 17

2006 ◽  
Vol 33 (S 1) ◽  
Author(s):  
P. Trillenberg ◽  
A. Sprenger ◽  
A. Hiller ◽  
C. Klein ◽  
G. Weinberger ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Spinocerebellar Ataxia Type ◽  
Hand Coordination ◽  
Spinocerebellar Ataxia Type 17
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