scholarly journals Dopamine D1 Receptors Regulate Spines in Striatal Direct‐Pathway and Indirect‐Pathway Neurons

2020 ◽  
Vol 35 (10) ◽  
pp. 1810-1821 ◽  
Author(s):  
Luz M. Suarez ◽  
Oscar Solis ◽  
Adrian Sanz‐Magro ◽  
Samuel Alberquilla ◽  
Rosario Moratalla
Keyword(s):  
D1 Receptors ◽  
Indirect Pathway ◽  
Dopamine D1 Receptors ◽  
Direct Pathway

scholarly journals Possible role of dopamine D1 receptors in schizophrenia

1997 ◽  
Vol 2 (4) ◽  
pp. 291-292 ◽  
Author(s):  
Y Okuba ◽  
T Suhara ◽  
Y Sudo ◽  
M Toru
Keyword(s):  
D1 Receptors ◽  
Dopamine D1 Receptors

Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents

1993 ◽  
Vol 242 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Val J. Watts ◽  
Cindy P. Lawler ◽  
John H. Gilmore ◽  
Stan B. Southerland ◽  
David E. Nichols ◽  
...  
Keyword(s):  
D1 Receptors ◽  
Dopamine D1 Receptors

#3101 Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntingtons disease: first evidence from human in vivo neuroimaging

2021 ◽  
Vol 92 (8) ◽  
pp. A6.1-A6
Author(s):  
Akshay Nair ◽  
Adeel Razi ◽  
Sarah Gregory ◽  
Robb Rutledge ◽  
Geraint Rees ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Bayesian Model ◽  
Empirical Bayes ◽  
Model Comparison ◽  
De Novo ◽  
Effective Connectivity ◽  
Indirect Pathway ◽  
Direct Pathway ◽  
Bayesian Model Comparison

BackgroundThe gating of movement in humans is thought to depend on activity within the cortico-striato-thalamic loops. Within these loops, emerging from the cells of the striatum, run two opponent pathways the direct and indirect pathway. Both are complex and polysynaptic but the overall effect of activity within these pathways is to encourage and inhibit movement respectively. In Huntingtons disease (HD), the preferential early loss of striatal neurons forming the indirect pathway is thought to lead to disinhibition that gives rise to the characteristic motor features of the condition. But early HD is also specifically associated with apathy, a failure to engage in goal-directed movement. We hypothesised that in HD, motor signs and apathy may be selectively correlated with indirect and direct pathway dysfunction respectively.MethodsUsing a novel technique for estimating dynamic effective connectivity of the basal ganglia, we tested both of these hypotheses in vivo for the first time in a large cohort of patients with prodromal HD (n = 94). We used spectral dynamic casual modelling of resting state fMRI data to model effective connectivity in a model of these cortico-striatal pathways. We used an advanced approach at the group level by combining Parametric Empirical Bayes and Bayesian Model Reduction procedure to generate large number of competing models and compare them by using Bayesian model comparison.ResultsWith this fully Bayesian approach, associations between clinical measures and connectivity parameters emerge de novo from the data. We found very strong evidence (posterior probability > 0.99) to support both of our hypotheses. Firstly, more severe motor signs in HD were associated with altered connectivity in the indirect pathway and by comparison, loss of goal-direct behaviour or apathy, was associated with changes in the direct pathway component of our model.ConclusionsThe empirical evidence we provide here is the first in vivo demonstration that imbalanced basal ganglia connectivity may play an important role in the pathogenesis of some of commonest and disabling features of HD and may have important implications for therapeutics.

Dopamine D1 receptors and age differences in brain activation during working memory

2011 ◽  
Vol 32 (10) ◽  
pp. 1849-1856 ◽  
Author(s):  
Lars Bäckman ◽  
Sari Karlsson ◽  
Håkan Fischer ◽  
Per Karlsson ◽  
Yvonne Brehmer ◽  
...  
Keyword(s):  
Working Memory ◽  
Age Differences ◽  
Brain Activation ◽  
D1 Receptors ◽  
Dopamine D1 Receptors

Can Expressing Positivity Elicit Support for Negative Events? A Process Model and Review

2020 ◽  
pp. 108886832096189
Author(s):  
Rebecca M. Walsh ◽  
Amanda L. Forest
Keyword(s):  
Process Model ◽  
Positive Mood ◽  
Future Research ◽  
Negative Events ◽  
Indirect Pathway ◽  
Potential Value ◽  
Direct Pathway ◽  
Do So

Garnering support for distressing experiences is highly important, yet notoriously challenging. We examine whether expressing positive thoughts and feelings when seeking support for negative events can help people elicit support, and we present a theoretical process model that explains why it might do so. The model includes three support-eliciting pathways through which expressing positivity could increase support: by strengthening providers’ prorelational motives, increasing providers’ positive mood, and enhancing providers’ expected support effectiveness. It also includes a support-suppressing pathway through which expressing positivity could decrease support: by undermining providers’ appraisals of support seekers’ needs. After presenting the model and providing evidence for each indirect pathway, we review research regarding the direct pathway. We then consider various types of positivity, discuss possible moderators, and identify directions for future research. Our model highlights support seekers’ underemphasized role in shaping support receipt and provides a novel perspective on positive expressivity’s potential value in distress-related contexts.

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