scholarly journals Subjective Cognitive Complaint in Parkinson's Disease Patients With Normal Cognition: Canary in the Coal Mine?

2020 ◽  
Vol 35 (9) ◽  
pp. 1618-1625 ◽  
Author(s):  
Rachael Purri ◽  
Laura Brennan ◽  
Jacqueline Rick ◽  
Sharon X. Xie ◽  
Benjamin L. Deck ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Coal Mine ◽  
Cognitive Complaint ◽  
Subjective Cognitive Complaint ◽  
Normal Cognition

scholarly journals Presence or absence of cognitive complaints in Parkinson’s disease: mood disorder or anosognosia?

2016 ◽  
Vol 74 (6) ◽  
pp. 439-444 ◽  
Author(s):  
Pollyanna Celso F. Castro ◽  
Camila Catherine Aquino ◽  
André C. Felício ◽  
Flávia Doná ◽  
Leonardo M. I. Medeiros ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Depression Scale ◽  
Cognitive Complaints ◽  
Boston Naming Test ◽  
Clock Drawing Test ◽  
Cognitive Complaint ◽  
Subjective Cognitive Complaint ◽  
And Control

ABSTRACT We intended to evaluate whether non-demented Parkinsons’s disease (PD) patients, with or without subjective cognitive complaint, demonstrate differences between them and in comparison to controls concerning cognitive performance and mood. We evaluated 77 subjects between 30 and 70 years, divided as follows: PD without cognitive complaints (n = 31), PD with cognitive complaints (n = 21) and controls (n = 25). We applied the following tests: SCOPA-Cog, Trail Making Test-B, Phonemic Fluency, Clock Drawing Test, Boston Naming Test, Neuropsychiatric Inventory, Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory. PD without complaints presented lower total score on Scales for outcome of Parkinson’s disease-cognition as compared to controls (p = 0.048). PD with complaints group showed higher scores on HADS (p = 0.011). PD without complaints group showed poorer cognitive performance compared to controls, but was similar to the PD with complaints group. Moreover, this group was different from the PD without complaints and control groups concerning mood.

Normal Cognition in Parkinson’s Disease may Involve Hippocampal Cholinergic Compensation: a PET Imaging Study with [18F]-FEOBV

2021 ◽  
Author(s):  
Camille Legault-Denis ◽  
Meghmik Aghourian ◽  
Jean-Paul Soucy ◽  
Pedro Rosa-Neto ◽  
Alain Dagher ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pet Imaging ◽  
Imaging Study ◽  
Normal Cognition

scholarly journals Dynamic functional connectivity changes associated with dementia in Parkinson’s disease

Brain ◽  
2019 ◽  
Vol 142 (9) ◽  
pp. 2860-2872 ◽  
Author(s):  
Eleonora Fiorenzato ◽  
Antonio P Strafella ◽  
Jinhee Kim ◽  
Roberta Schifano ◽  
Luca Weis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Parkinson’S Disease Dementia ◽  
Dynamic Functional Connectivity ◽  
Control Subjects ◽  
Healthy Control ◽  
Normal Cognition

AbstractDynamic functional connectivity captures temporal variations of functional connectivity during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson’s disease. In this study, we evaluated 118 patients with Parkinson’s disease matched for age, sex and education with 35 healthy control subjects. Patients with Parkinson’s disease were classified with normal cognition (n = 52), mild cognitive impairment (n = 46), and dementia (n = 20) based on an extensive neuropsychological evaluation. Resting state functional MRI and a sliding-window approach were used to study the dynamic functional connectivity. Dynamic analysis suggested two distinct connectivity ‘States’ across the entire group: a more frequent, segregated brain state characterized by the predominance of within-network connections, State I, and a less frequent, integrated state with strongly connected functional internetwork components, State II. In Parkinson’s disease, State I occurred 13.89% more often than in healthy control subjects, paralleled by a proportional reduction of State II. Parkinson’s disease subgroups analyses showed the segregated state occurred more frequently in Parkinson’s disease dementia than in mild cognitive impairment and normal cognition groups. Further, patients with Parkinson’s disease dementia dwelled significantly longer in the segregated State I, and showed a significant lower number of transitions to the strongly interconnected State II compared to the other subgroups. Our study indicates that dementia in Parkinson’s disease is characterized by altered temporal properties in dynamic connectivity. In addition, our results show that increased dwell time in the segregated state and reduced number of transitions between states are associated with presence of dementia in Parkinson’s disease. Further studies on dynamic functional connectivity changes could help to better understand the progressive dysfunction of networks between Parkinson’s disease cognitive states.

Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson’s disease patients

2018 ◽  
Vol 13 (1) ◽  
pp. 232-240 ◽  
Author(s):  
Maria Chondrogiorgi ◽  
Loukas G. Astrakas ◽  
Anastasia K. Zikou ◽  
Luca Weis ◽  
Vassilios G. Xydis ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Normal Cognition

Cognitive complaint in early Parkinson's disease: A pilot study

2017 ◽  
Vol 137 (1) ◽  
pp. 59-66 ◽  
Author(s):  
J. Dupouy ◽  
F. Ory-Magne ◽  
C. Mekies ◽  
V. Rousseau ◽  
M. Puel ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pilot Study ◽  
Cognitive Complaint ◽  
Early Parkinson’S Disease

scholarly journals White matter alterations in Parkinson’s disease with normal cognition precede grey matter atrophy

2018 ◽  
Vol 46 ◽  
pp. e9-e10
Author(s):  
I. Rektor ◽  
A. Svátková ◽  
L. Vojtíšek ◽  
I. Zikmundová ◽  
J. Vaníček ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Grey Matter ◽  
Normal Cognition ◽  
Grey Matter Atrophy

Fist-Edge-Palm (FEP) test has a high sensitivity in differentiating dementia from normal cognition in Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 118060
Author(s):  
Ye Liu ◽  
Meng-Yao Qiu ◽  
Yu-Lei Zhang ◽  
Xiao-Jin Zhang ◽  
Daniel Truong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Sensitivity ◽  
Normal Cognition

scholarly journals White matter alterations in Parkinson’s disease with normal cognition precede grey matter atrophy

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0187939 ◽  
Author(s):  
Ivan Rektor ◽  
Alena Svátková ◽  
Lubomir Vojtíšek ◽  
Iva Zikmundová ◽  
Jirí Vaníček ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Grey Matter ◽  
Normal Cognition ◽  
Grey Matter Atrophy
Sign in / Sign up

Export Citation Format

Share Document