Role of Glial Cell Line‐Derived Neurotrophic Factor in the Maintenance of Adult Mesencephalic Catecholaminergic Neurons

2020 ◽  
Vol 35 (4) ◽  
pp. 565-576 ◽  
Author(s):  
Daniel Enterría‐Morales ◽  
Ivette López‐López ◽  
José López‐Barneo ◽  
Xavier d'Anglemont de Tassigny
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Catecholaminergic Neurons

scholarly journals The major determinant of the heparin binding of glial cell-line-derived neurotrophic factor is near the N-terminus and is dispensable for receptor binding

2007 ◽  
Vol 404 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Ivan Alfano ◽  
Parvez Vora ◽  
Rosemary S. Mummery ◽  
Barbara Mulloy ◽  
Christopher C. Rider
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Transforming Growth Factor ◽  
Basic Amino Acid ◽  
Transforming Growth Factor Β ◽  
Heparin Binding ◽  
Binding Sequence

GDNF (glial cell-line-derived neurotrophic factor), and the closely related cytokines artemin and neurturin, bind strongly to heparin. Deletion of a basic amino-acid-rich sequence of 16 residues N-terminal to the first cysteine of the transforming growth factor β domain of GDNF results in a marked reduction in heparin binding, whereas removal of a neighbouring sequence, and replacement of pairs of other basic residues with alanine had no effect. The heparin-binding sequence is quite distinct from the binding site for the high affinity GDNF polypeptide receptor, GFRα1 (GDNF family receptor α1), and heparin-bound GDNF is able to bind GFRα1 simultaneously. The heparin-binding sequence of GDNF is dispensable both for GFRα1 binding, and for activity for in vitro neurite outgrowth assay. Surprisingly, the observed inhibition of GDNF bioactivity with the wild-type protein in this assay was still found with the deletion mutant lacking the heparin-binding sequence. Heparin neither inhibits nor potentiates GDNF–GFRα1 interaction, and the extracellular domain of GFRα1 does not bind to heparin itself, precluding heparin cross-bridging of cytokine and receptor polypeptides. The role of heparin and heparan sulfate in GDNF signalling remains unclear, but the present study indicates that it does not occur in the first step of the pathway, namely GDNF–GFRα1 engagement.

Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration

Neuroscience ◽  
2003 ◽  
Vol 122 (1) ◽  
pp. 229-235 ◽  
Author(s):  
C Harada ◽  
T Harada ◽  
H.-M.A Quah ◽  
F Maekawa ◽  
K Yoshida ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Cell Line ◽  
Glial Cell ◽  
Glial Cells ◽  
Neurotrophic Factor ◽  
Potential Role ◽  
Müller Glial Cells

The role of glial cell line-derived neurotrophic factor on invasive mechanism of pancreatic cancer cells

Pancreatology ◽  
2013 ◽  
Vol 13 (4) ◽  
pp. S16
Author(s):  
Hitoshi Funahashi ◽  
Hiroki Takahashi ◽  
Yoichi Matsuo ◽  
Hideyuki Ishiguro ◽  
Yuji Okada ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Pancreatic Cancer Cells ◽  
Invasive Mechanism

scholarly journals The Role of Glial Cell Line-Derived Neurotrophic Factor in the Functioning of the Nervous System (Review)

2015 ◽  
Vol 7 (4) ◽  
pp. 211-220 ◽  
Author(s):  
T.V. Shishkina ◽  
M.V. Vedunova ◽  
T.A. Mishchenko ◽  
I.V. Mukhina
Keyword(s):  
Nervous System ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
System Review

scholarly journals Adaptive Role of Glial Cell Line-Derived Neurotrophic Factor in Cerebral Ischemia

2017 ◽  
Vol 9 (1) ◽  
pp. 68
Author(s):  
E.V. Mitroshina ◽  
B.Zh. Abogessimengane ◽  
M.D. Urazov ◽  
I. Hamraoui ◽  
T.A. Mishchenko ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Adaptive Role

A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury

2004 ◽  
Vol 189 (2) ◽  
pp. 317-332 ◽  
Author(s):  
C IANNOTTI ◽  
Y PINGZHANG ◽  
C SHIELDS ◽  
Y HAN ◽  
D BURKE ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Contusion Injury ◽  
Spinal Cord Contusion
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