scholarly journals Comparison of phosphodiesterase 10A and dopamine transporter levels as markers of disease burden in early Parkinson's disease

2019 ◽  
Vol 34 (10) ◽  
pp. 1505-1515 ◽  
Author(s):  
Gennaro Pagano ◽  
Flavia Niccolini ◽  
Heather Wilson ◽  
Tayyabah Yousaf ◽  
Naheed L. Khan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Disease Burden ◽  
Phosphodiesterase 10A ◽  
Early Parkinson’S Disease

scholarly journals Molecular Neuroimaging of the Dopamine Transporter as a Patient Enrichment Biomarker for Clinical Trials for Early Parkinson's Disease

2019 ◽  
Vol 12 (3) ◽  
pp. 240-246 ◽  
Author(s):  
Klaus Romero ◽  
Daniela Conrado ◽  
Jackson Burton ◽  
Timothy Nicholas ◽  
Vikram Sinha ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Dopamine Transporter ◽  
Early Parkinson’S Disease

Nigrostriatal dopamine transporter availability in early Parkinson's disease

2018 ◽  
Vol 33 (4) ◽  
pp. 592-599 ◽  
Author(s):  
Patrik Fazio ◽  
Per Svenningsson ◽  
Zsolt Cselényi ◽  
Christer Halldin ◽  
Lars Farde ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Nigrostriatal Dopamine ◽  
Early Parkinson’S Disease

scholarly journals Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes

Brain ◽  
2019 ◽  
Vol 142 (11) ◽  
pp. 3565-3579 ◽  
Author(s):  
Yaping Chu ◽  
Scott Muller ◽  
Adriana Tavares ◽  
Olivier Barret ◽  
David Alagille ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Lewy Body ◽  
Alpha Synuclein ◽  
Lewy Body Pathology ◽  
Nigrostriatal Degeneration ◽  
Early Parkinson’S Disease

See Dehay and Bezard (doi:10.1093/brain/awz329) for a scientific commentary on this article. Intrastriatal injections of fibrillar α-synuclein in rodents have been shown to induce a Parkinson’s disease-like spreading of Lewy body pathology. Chu et al. inject exogenous α-synuclein pre-formed fibrils into the putamen of non-human primates, and observe spreading of pathology, nigrostriatal degeneration, and dopamine transporter upregulation indicative of early Parkinson’s disease.

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