Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson's disease

2019 ◽  
Vol 34 (6) ◽  
pp. 903-911 ◽  
Author(s):  
Coralie Hemptinne ◽  
Doris D. Wang ◽  
Svjetlana Miocinovic ◽  
Witney Chen ◽  
Jill L. Ostrem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Gamma Oscillations

scholarly journals Enhancing Gamma Oscillations Restores Primary Motor Cortex Plasticity in Parkinson's Disease

2020 ◽  
Vol 40 (24) ◽  
pp. 4788-4796 ◽  
Author(s):  
Andrea Guerra ◽  
Francesco Asci ◽  
Valentina D'Onofrio ◽  
Valerio Sveva ◽  
Matteo Bologna ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Gamma Oscillations ◽  
Motor Cortex Plasticity

scholarly journals Pallidal Thermolesion Unleashes Gamma Oscillations in the Motor Cortex in Parkinson's Disease

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Doris D Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Witney Chen ◽  
Jill L Ostrem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Essential Tremor ◽  
Primary Motor Cortex ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Motor Dysfunction ◽  
Oscillatory Activity ◽  
Motor Network

Abstract INTRODUCTION In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance between antikinetic and prokinetic patterns of oscillatory activity in the motor network. Invasive recordings from the basal ganglia and cortex in surgical patients have suggested that levodopa and therapeutic deep brain stimulation can suppress antikinetic beta band (13-30 Hz) rhythms while promoting prokinetic gamma band (60-90 Hz) rhythms. Surgical ablation of the globus pallidus internus is one of the oldest effective therapies for Parkinson's disease and gives a remarkable immediate relief from rigidity and bradykinesia, but its effects on oscillatory activity in the motor network have not been studied. We characterize the effects of pallidotomy on cortical oscillatory activity in Parkinson's disease patients. METHODS Using a temporary 6-contact lead placed over the sensorimotor cortex in the subdural space, we recorded acute changes in cortical oscillatory activities in 3 Parkinson's disease patients undergoing pallidotomy and compared the results to that of 3 essential tremor patients undergoing thalamotomy. RESULTS In all 3 Parkinson's disease patients, we observed the emergence of an approximately 70 to 80 Hz narrow-band oscillation with effective thermolesion of the pallidum. This gamma oscillatory activity was spatially localized over the primary motor cortex, was minimally affected by voluntary movements, and was not found in the motor cortex of essential tremor patients undergoing thalamotomy. CONCLUSION Our finding suggests that acute lesioning of the pallidum promotes cortical gamma band oscillations. This may represent an important mechanism for alleviating bradykinesia in Parkinson's disease.

Modulation of motor cortex by subthalamic stimulation in Parkinson's disease

2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
B Haslinger ◽  
K Kalteis ◽  
F Alesch ◽  
H Boecker ◽  
AO Ceballos-Baumann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Subthalamic Stimulation

scholarly journals Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome

2021 ◽  
Vol 11 (4) ◽  
pp. 416
Author(s):  
Carla Piano ◽  
Francesco Bove ◽  
Delia Mulas ◽  
Enrico Di Stasio ◽  
Alfonso Fasano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Clinical Outcome ◽  
Motor Cortex Stimulation ◽  
Dopaminergic Therapy

Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.

Motor cortex stimulation for Parkinson's disease: a modelling study

2012 ◽  
Vol 9 (5) ◽  
pp. 056005 ◽  
Author(s):  
Daphne G M Zwartjes ◽  
Tjitske Heida ◽  
Hans K P Feirabend ◽  
Marcus L F Janssen ◽  
Veerle Visser-Vandewalle ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Motor Cortex Stimulation ◽  
Modelling Study

Motor cortex reorganisation in Parkinson’s disease

2006 ◽  
Vol 13 (6) ◽  
pp. 639-642 ◽  
Author(s):  
Gary W. Thickbroom ◽  
Michelle L. Byrnes ◽  
Susan Walters ◽  
Rick Stell ◽  
Frank L. Mastaglia
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex

scholarly journals Enhanced Synchrony among Primary Motor Cortex Neurons in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Primate Model of Parkinson's Disease

2002 ◽  
Vol 22 (11) ◽  
pp. 4639-4653 ◽  
Author(s):  
Joshua A. Goldberg ◽  
Thomas Boraud ◽  
Sharon Maraton ◽  
Suzanne N. Haber ◽  
Eilon Vaadia ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Primate Model
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