Sleep dysfunction in Parkinson's disease: Novel molecular mechanism and implications for therapy

2018 ◽  
Vol 33 (10) ◽  
pp. 1558-1559 ◽  
Author(s):  
Marija Dulovic ◽  
Melissa Vos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
Sleep Dysfunction

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

2018 ◽  
Vol 9 (11) ◽  
pp. 2849-2858 ◽  
Author(s):  
Alice Biosa ◽  
Irene Arduini ◽  
Maria Eugenia Soriano ◽  
Valentina Giorgio ◽  
Paolo Bernardi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
Oxidation Products ◽  
Dopamine Oxidation

scholarly journals HIGH-MOBILITY GROUP BOX 1 (HMGB1) PROTEIN EVALUATION IN MPTP-INDUCED ZEBRAFISH MODEL OF PARKINSON’S DISEASE

2021 ◽  
Author(s):  
Wael MY Mohamed ◽  
Khairiah Razali ◽  
Noratikah Othman ◽  
Mohamed Hamza ◽  
Abdel Moneem Doolane ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Mechanism ◽  
High Mobility ◽  
High Mobility Group ◽  
Current Evidence ◽  
Hmgb1 Protein ◽  
Zebrafish Model ◽  
Molecular Studies

Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current evidence reported on the association of HMGB1 protein with neuroinflammation-induced PD pathogenesis. However, to the extent ofour knowledge, the molecular mechanism pertaining to HMGB1 involvement in PD are still elusive. Hence, we propose to conduct a study on HMGB1 protein, to elucidate its role in the pathogenesis of the MPTP-induced zebrafish model of PD. This study will answer the question pertaining to the involvement of HMGB1 in PD development and whether the knockdown of this protein can improve PD symptoms in zebrafish, particularly MPTP-induced motilitydisorders.

Update on the clinical application of deep brain stimulation in sleep dysfunction of Parkinson’s disease

2018 ◽  
Vol 118 (3) ◽  
pp. 351-359 ◽  
Author(s):  
Shuang Zou ◽  
Yu-Long Lan ◽  
Ya-Ping Hu ◽  
Xiao-Xue Yin ◽  
Wen-Long Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Clinical Application ◽  
Brain Stimulation ◽  
Sleep Dysfunction ◽  
Deep Brain

Subjective sleep dysfunction and insomnia symptoms in Parkinson's disease: Insights from a cross-sectional evaluation of the French CoPark cohort

2015 ◽  
Vol 21 (11) ◽  
pp. 1323-1329 ◽  
Author(s):  
Pietro-Luca Ratti ◽  
Laurence Nègre-Pagès ◽  
Santiago Pérez-Lloret ◽  
Raffaele Manni ◽  
Philippe Damier ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cross Sectional ◽  
Subjective Sleep ◽  
Sleep Dysfunction ◽  
Insomnia Symptoms

scholarly journals Treatment of Sleep Dysfunction in Parkinson’s Disease

2017 ◽  
Vol 19 (7) ◽  
Author(s):  
Amy W. Amara ◽  
Lana M. Chahine ◽  
Aleksandar Videnovic
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Dysfunction
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