Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease

2017 ◽  
Vol 32 (10) ◽  
pp. 1401-1408 ◽  
Author(s):  
Jean-Pierre Trezzi ◽  
Sara Galozzi ◽  
Christian Jaeger ◽  
Katalin Barkovits ◽  
Kathrin Brockmann ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Early Parkinson’S Disease

scholarly journals Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease

2021 ◽  
Author(s):  
Thomas Kremer ◽  
Kirsten I. Taylor ◽  
Juliane Siebourg‐Polster ◽  
Thomas Gerken ◽  
Andreas Staempfli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Longitudinal Analysis ◽  
Early Parkinson’S Disease ◽  
Neurotransmitter Metabolites

scholarly journals Amyloid-β and α-synuclein cerebrospinal fluid biomarkers and cognition in early Parkinson's disease

2015 ◽  
Vol 21 (7) ◽  
pp. 758-764 ◽  
Author(s):  
Ane Løvli Stav ◽  
Dag Aarsland ◽  
Krisztina Kunszt Johansen ◽  
Erik Hessen ◽  
Eirik Auning ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Cerebrospinal Fluid Biomarkers ◽  
Early Parkinson’S Disease

scholarly journals MicroRNA-409-3p Targeting at ATXN3 Reduces the Apoptosis of Dopamine Neurons Based on the Profile of miRNAs in the Cerebrospinal Fluid of Early Parkinson’s Disease

2022 ◽  
Vol 9 ◽  
Author(s):  
Xuling Tan ◽  
Junjian Hu ◽  
Fengyu Ming ◽  
Lingling Lv ◽  
Weiqian Yan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Dopamine Neurons ◽  
Luciferase Reporter ◽  
Luciferase Reporter Gene ◽  
Real Time Quantitative Pcr ◽  
Gene Assay ◽  
Next Generation Sequencing Ngs ◽  
Early Parkinson’S Disease

Precise recognition of early Parkinson’s disease (PD) has always been a challenging task requiring more feasible biomarkers to be integrated to improve diagnostic accuracy. MicroRNAs (miRNAs) of cerebrospinal fluid (CSF) are believed to be potential and promising candidate biomarkers for PD. However, the role of altered miRNAs of CSF play in PD is unclear. Here, we recruited patients with early stages of PD and controls to analyze the expression of miRNA in CSF by the Next Generation Sequencing (NGS). Furthermore, we tested the levels of these miRNA in SH-SY5Y cells treated with MPP+ using real-time quantitative PCR. We found 21 miRNAs were upregulated in CSF of early PD patients and miR-409-3p, one of the identified 21 miRNAs, was further confirmed in SH-SY5Y cells treated with MPP+. Also, more cells survived in the overexpression of the miR-409-3p group when SH-SY5Y cells and mice were treated with MPP+ and MPTP, respectively. Mechanistically, we demonstrated the binding of miR-409-3p and 3’UTR of ATXN3 through a dual luciferase reporter gene assay. Moreover, miR-409-3p mimic reduced the aggregation of polyglutamine-expanded mutant of ATXN3 and apoptosis. Our results provide experimental evidence for miR-409-3p in CSF as a diagnostic marker of PD.

scholarly journals Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease

2020 ◽  
Vol 88 (3) ◽  
pp. 574-587 ◽  
Author(s):  
David J. Irwin ◽  
Janel Fedler ◽  
Christopher S. Coffey ◽  
Chelsea Caspell‐Garcia ◽  
Ju Hee Kang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Biomarkers ◽  
Early Parkinson’S Disease

scholarly journals Longitudinal analyses of cerebrospinal fluid α‐Synuclein in prodromal and early Parkinson's disease

2019 ◽  
Vol 34 (9) ◽  
pp. 1354-1364 ◽  
Author(s):  
Brit Mollenhauer ◽  
Chelsea J. Caspell‐Garcia ◽  
Christopher S. Coffey ◽  
Peggy Taylor ◽  
Andy Singleton ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Longitudinal Analyses ◽  
Early Parkinson’S Disease

Integrity of the blood–cerebrospinal fluid barrier in early Parkinson's disease

2001 ◽  
Vol 300 (3) ◽  
pp. 182-184 ◽  
Author(s):  
Peter Haussermann ◽  
Wilfried Kuhn ◽  
Horst Przuntek ◽  
Thomas Muller
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Early Parkinson’S Disease
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