Neuromelanin magnetic resonance imaging of the substantia nigra in LRRK2 -related Parkinson's disease

2017 ◽  
Vol 32 (9) ◽  
pp. 1331-1333 ◽  
Author(s):  
Leonor Correia Guedes ◽  
Sofia Reimão ◽  
Patrícia Paulino ◽  
Rita G. Nunes ◽  
Raquel Bouça-Machado ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Resonance Imaging

Magnetic resonance imaging of the substantia nigra in Parkinson's disease

2012 ◽  
Vol 27 (7) ◽  
pp. 822-830 ◽  
Author(s):  
Stéphane Lehéricy ◽  
Michael A. Sharman ◽  
Clarisse Longo Dos Santos ◽  
Raphaël Paquin ◽  
Cecile Gallea
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Resonance Imaging

scholarly journals New Magnetic Resonance Imaging Biomarkers Advance the Characterisation of Parkinson’s Disease

2013 ◽  
Vol 8 (2) ◽  
pp. 85 ◽  
Author(s):  
David A Ziegler ◽  
Suzanne Corkin ◽  
◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Structural Mri ◽  
Careful Examination ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

The pathophysiology of idiopathic Parkinson’s disease (PD) is traditionally characterised as substantia nigra degeneration, but careful examination of the widespread neuropathological changes suggests individual differences in neuronal vulnerability. A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by the disease, and thus are not typically used in experimental or clinical studies. Here, we review the current state of structural MRI as applied to the analysis of the PD brain. We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories of volume loss early in the disease.

scholarly journals A distinct neuromelanin magnetic resonance imaging pattern in parkinsonian multiple system atrophy

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Rita Moiron Simões ◽  
Ana Castro Caldas ◽  
Joana Grilo ◽  
Daisy Correia ◽  
Carla Guerreiro ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Multiple System Atrophy ◽  
Locus Coeruleus ◽  
Disease Duration ◽  
Imaging Analysis ◽  
Resonance Imaging

Abstract Background Parkinsonian variant of multiple system atrophy is a neurodegenerative disorder frequently misdiagnosed as Parkinson’s disease. No early imaging biomarkers currently differentiate these disorders. Methods Simple visual imaging analysis of the substantia nigra and locus coeruleus in neuromelanin-sensitive magnetic resonance imaging and nigrosome 1 in susceptibility-weighted sequences was performed in thirty patients with parkinsonian variant of multiple system atrophy fulfilling possible/probable second consensus diagnostic criteria. The neuromelanin visual pattern was compared to patients with Parkinson’s disease with the same disease duration (n = 10) and healthy controls (n = 10). Substantia nigra semi-automated neuromelanin area/signal intensity was compared to the visual data. Results Groups were similar in age, sex, disease duration, and levodopa equivalent dose. Hoehn & Yahr stage was higher in parkinsonian multiple system atrophy patients, 69% of whom had normal neuromelanin size/signal, significantly different from Parkinson’s disease patients, and similar to controls. Nigrosome 1 signal was lost in 74% of parkinsonian multiple system atrophy patients. Semi-automated neuromelanin substantia nigra signal, but not area, measurements were able to differentiate groups. Conclusions In patients with parkinsonism, simple visual magnetic resonance imaging analysis showing normal neuromelanin substantia nigra and locus coeruleus, combined with nigrosome 1 loss, allowed the distinction of the parkinsonian variant of multiple system atrophy from Parkinson’s disease and healthy controls. This easy and widely available method was superior to semi-automated measurements in identifying specific imaging changes in substantia nigra and locus coeruleus.

7 tesla magnetic resonance imaging: A closer look at substantia nigra anatomy in Parkinson's disease

2014 ◽  
Vol 29 (13) ◽  
pp. 1574-1581 ◽  
Author(s):  
Stéphane Lehéricy ◽  
Eric Bardinet ◽  
Cyril Poupon ◽  
Marie Vidailhet ◽  
Chantal François
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
7 Tesla ◽  
Resonance Imaging
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