Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

2017 ◽  
Vol 32 (6) ◽  
pp. 820-832 ◽  
Author(s):  
Amol P. Yadav ◽  
Miguel A. L. Nicolelis
Keyword(s):  
Parkinson’S Disease ◽  
Spinal Cord ◽  
Parkinson's Disease ◽  
Electrical Stimulation ◽  
Dorsal Columns ◽  
Stimulation Of

Pharmacotherapy on the Background of Electrical Stimulation of the Subthalamic Nucleus in Patients with Parkinson’s Disease

2017 ◽  
Vol 47 (3) ◽  
pp. 275-280
Author(s):  
E. V. Bril’ ◽  
A. A. Tomskii ◽  
A. A. Gamaleya ◽  
A. A. Poddubskaya ◽  
N. V. Fedorova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Electrical Stimulation ◽  
Subthalamic Nucleus ◽  
Stimulation Of

Electrical Stimulation of the Prelemniscal Radiation in the Treatment of Parkinson's Disease: An Old Target Revised with New Techniques

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 293-308 ◽  
Author(s):  
Francisco Velasco ◽  
Fiacro Jiménez ◽  
Martha Luisa Pérez ◽  
José D. Carrillo-Ruiz ◽  
Ana Luisa Velasco ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Electrical Stimulation ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Term Trial ◽  
Stimulation Of

Abstract OBJECTIVE In the treatment of tremor and rigidity in patients with Parkinson's disease (PD), the prelemniscal radiation (RAPRL), a subthalamic bundle of fibers, is an exquisite target that can be visualized easily on ventriculograms. We sought to evaluate the effect of electrical stimulation of the RAPRL on symptoms and signs of PD in a long-term trial and to determine the localization of the stimulated area by means of stereotactic magnetic resonance imaging studies. METHODS Ten patients with PD predominantly on one side had tetrapolar electrodes stereotactically oriented through a frontal parasagittal approach to the RAPRL contralateral to the most prominent symptoms. Preoperative and postoperative evaluations at 3, 6, 9, and 12 months after surgery were performed using conventional PD scales and quantitative evaluations of tremor amplitude and reaction time. Stereotactic high-resolution magnetic resonance imaging studies with the electrodes in place were used for anatomic localization. RESULTS In all patients, temporary suppression of tremor occurred when the electrodes reached the target. The most effective stimulation was obtained when the pair of contacts was placed in the RAPRL. Long-term stimulation at 130 Hz, 0.09 to 0.450 milliseconds, and 1.5 to 3.0 V produced significant improvement in tremor and rigidity and mild improvement in bradykinesia. CONCLUSION The RAPRL is an effective target for the alleviation of tremor and rigidity in patients with PD by either lesioning or neuromodulation; however, neuromodulation has the advantage of not inducing an increase in bradykinesia. The stimulated area seems to be independent of the subthalamic nucleus.

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