Reply: Mild cognitive impairment in de novo Parkinson's disease according to Movement Disorder guidelines

2012 ◽  
Vol 27 (13) ◽  
pp. 1707-1707 ◽  
Author(s):  
Irene Litvan ◽  
Jennifer G. Goldman ◽  
Alex I. Tröster ◽  
Ben A. Schmand ◽  
Dan Weintraub
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Movement Disorder ◽  
De Novo

Mild cognitive impairment in De Novo Parkinson's disease according to movement disorder guidelines

2012 ◽  
Vol 27 (13) ◽  
pp. 1706-1706 ◽  
Author(s):  
Michele Poletti ◽  
Daniela Frosini ◽  
Roberto Ceravolo ◽  
Ubaldo Bonuccelli
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Movement Disorder ◽  
De Novo

Mild cognitive impairment in de novo Parkinson's disease: A neuromelanin MRI study in locus coeruleus

2019 ◽  
Vol 34 (6) ◽  
pp. 884-892 ◽  
Author(s):  
Yuanfang Li ◽  
Changpeng Wang ◽  
Jian Wang ◽  
Ying Zhou ◽  
Fang Ye ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Locus Coeruleus ◽  
De Novo ◽  
Mri Study

scholarly journals Differential functional connectivity of insular subdivisions in de novo Parkinson’s Disease with mild cognitive impairment

2021 ◽  
Author(s):  
Chenxi Pan ◽  
Jingru Ren ◽  
Lanting Li ◽  
Yuqian Li ◽  
Jianxia Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Cognitive Abilities ◽  
De Novo ◽  
Cognitive Disorders ◽  
The Right

Abstract The insula, consisting of functionally diverse subdivisions, plays a significant role in Parkinson’s disease (PD)-related cognitive disorders. However, the functional connectivity (FC) patterns of insular subdivisions in PD remain unclear. Our aim is to investigate the changes in FC patterns of insular subdivisions and their relationships with cognitive domains. Three groups of participants were recruited in this study, including PD patients with mild cognitive impairment (PD-MCI, n = 25), PD patients with normal cognition (PD-NC, n = 13), and healthy controls (HCs, n = 17). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to investigate the FC in insular subdivisions of the three groups. Moreover, all participants underwent a neuropsychological battery to assess cognition so that the relationship between altered FC and cognitive performance could be elucidated. Compared with the PD-NC group, the PD-MCI group exhibited increased FC between the left dorsal anterior insular (dAI) and the right superior parietal gyrus (SPG), and altered FC was negatively correlated with memory and executive function. Compared with the HC group, the PD-MCI group showed significantly increased FC between the right dAI and the right median cingulate and paracingulate gyri (DCG), and altered FC was positively related to attention/working memory, visuospatial function, and language. Our findings highlighted the different abnormal FC patterns of insular subdivisions in PD patients with different cognitive abilities. Furthermore, dysfunction of the dAI may partly contribute to the decline in executive function and memory in early drug-naïve PD patients.

scholarly journals Mild Cognitive Impairment in de novo Parkinson's Disease: Selective Attention Deficit as Early Sign of Neurocognitive Decay

2021 ◽  
Vol 12 ◽  
Author(s):  
Davide Maria Cammisuli ◽  
Cristina Pagni ◽  
Giovanni Palermo ◽  
Daniela Frosini ◽  
Joyce Bonaccorsi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Selective Attention ◽  
Attention Deficit ◽  
De Novo ◽  
Clinical Neurology ◽  
Dopamine Depletion ◽  
Attentional Deficits

Background: In the present study, we aimed to better investigate attention system profile of Parkinson's disease-Mild Cognitive Impairment (PD-MCI) patients and to determine if specific attentional deficits are associated with 123I-FP-CIT SPECT.Methods: A total of 44 de novo drug-naïve PD patients [(27) with normal cognition (PD-NC) and 17 with MCI (PD-MCI)], 23 MCI patients and 23 individuals with subjective cognitive impairment (SCI) were recruited at the Clinical Neurology Unit of Santa Chiara hospital (Pisa University Medical School, Italy). They were assessed by a wide neuropsychological battery, including Visual Search Test (VST) measuring selective attention. Performances among groups were compared by non-parametric tests (i.e., Kruskal-Wallis and Mann-Whitney, Bonferroni corrected). Further, Spearman's rank correlations were performed to explore the association between neuropsychological variables and 123I-FP-CIT SPECT data in PD subgroup.Results: PD-MCI patients performed worse on VST than patients with PD-NC (p = 0.002), patients with MCI and individuals with SCI (p < 0.001). The performance of PD-MCI patients on VST significantly correlated with caudate nucleus 123I-FP-CIT SPECT uptake (rho = 0.582, p < 0.05), whereas a negative correlation between such test and 123I-FP-CIT SPECT uptake in the left putamen (rho = −0.529, p < 0.05) was found in PD-NC patients.Conclusions: We suggest that selective attention deficit might be a trigger of cognitive decay in de novo PD-MCI patients. The VST should be routinely used to detect attentional deficits in hospital clinical practice, in the light of its closely association with dopamine depletion of basal ganglia in mildly impaired PD patients.

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