Taking sides: Is handedness involved in motor asymmetry of Parkinson's disease?

2012 ◽  
Vol 27 (2) ◽  
pp. 171-173 ◽  
Author(s):  
Eldad Melamed ◽  
Werner Poewe
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Asymmetry

scholarly journals The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

2021 ◽  
Vol 11 (2) ◽  
pp. 455-474
Author(s):  
Per Borghammer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Explanatory Power ◽  
Anatomical Location ◽  
Asymmetric Distribution ◽  
Motor Asymmetry ◽  
Parasympathetic Innervation ◽  
Considerable Body ◽  
Dopaminergic Degeneration

A new model of Parkinson’s disease (PD) pathogenesis is proposed, the α-Synuclein Origin site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology that impact the disease course for each patient: the anatomical location of the initial α-synuclein inclusion, and α-synuclein propagation dependent on the ipsilateral connections that dominate connectivity of the human brain. In some patients, initial α-synuclein pathology occurs within the CNS, leading to a brain-first subtype of PD. In others, pathology begins in the peripheral autonomic nervous system, leading to a body-first subtype. In brain-first cases, it is proposed that the first pathology appears unilaterally, often in the amygdala. If α-synuclein propagation depends on connection strength, a unilateral focus of pathology will disseminate more to the ipsilateral hemisphere. Thus, α-synuclein spreads mainly to ipsilateral structures including the substantia nigra. The asymmetric distribution of pathology leads to asymmetric dopaminergic degeneration and motor asymmetry. In body-first cases, the α-synuclein pathology ascends via the vagus to both the left and right dorsal motor nuclei of the vagus owing to the overlapping parasympathetic innervation of the gut. Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading to more symmetric dopaminergic degeneration and less motor asymmetry. At diagnosis, body-first patients already have a larger, more symmetric burden of α-synuclein pathology, which in turn promotes faster disease progression and accelerated cognitive decline. The SOC model is supported by a considerable body of existing evidence and may have improved explanatory power.

Motor asymmetry and estimation of body-scaled aperture width in Parkinson's disease

2011 ◽  
Vol 49 (11) ◽  
pp. 3002-3010 ◽  
Author(s):  
J.G. Smith ◽  
J.P. Harris ◽  
S. Khan ◽  
E.A. Atkinson ◽  
M.S. Fowler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Asymmetry ◽  
Aperture Width

Motor asymmetry and neuromelanin imaging: Concordance in Parkinson's disease

2018 ◽  
Vol 53 ◽  
pp. 28-32 ◽  
Author(s):  
Shweta Prasad ◽  
Jitender Saini ◽  
Ravi Yadav ◽  
Pramod Kumar Pal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Asymmetry

scholarly journals Motor Asymmetry and Interocular Retinal Thickness in Parkinson's Disease

2021 ◽  
Vol 36 (6) ◽  
Author(s):  
Sung Uk Baek ◽  
Suk Yun Kang ◽  
Soonil Kwon ◽  
In Won Park ◽  
Wool Suh
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Retinal Thickness ◽  
Motor Asymmetry

scholarly journals Subthalamic nucleus oscillations during vocal emotion processing are dependent of the motor asymmetry of Parkinson's disease

NeuroImage ◽  
2020 ◽  
Vol 222 ◽  
pp. 117215 ◽  
Author(s):  
Damien Benis ◽  
Claire Haegelen ◽  
Philippe Voruz ◽  
Jordan Pierce ◽  
Valérie Milesi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Emotion Processing ◽  
Motor Asymmetry ◽  
Vocal Emotion

scholarly journals Asymmetrical nigral iron accumulation in Parkinson’s disease with motor asymmetry: an explorative, longitudinal and test-retest study

Aging ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 18622-18634
Author(s):  
Xiaojun Guan ◽  
Tao Guo ◽  
Cheng Zhou ◽  
Jingjing Wu ◽  
Ting Gao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iron Accumulation ◽  
Motor Asymmetry

P19 Impaired self-awareness of motor deficits in Parkinson’s disease: Association with motor asymmetry and motor phenotypes

Basal Ganglia ◽  
2011 ◽  
Vol 1 (2) ◽  
pp. 112
Author(s):  
Franziska Maier ◽  
George P. Prigatano ◽  
Elke Kalbe ◽  
Michael T. Barbe ◽  
Carsten Eggers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Association ◽  
Motor Deficits ◽  
Self Awareness ◽  
Motor Asymmetry
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