scholarly journals Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications

2011 ◽  
Vol 26 (8) ◽  
pp. 1386-1397 ◽  
Author(s):  
Zhenyu Yue ◽  
M. Lenard Lachenmayer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Applications

scholarly journals Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease

2018 ◽  
Vol 9 ◽  
Author(s):  
Muthuraman Muthuraman ◽  
Nabin Koirala ◽  
Dumitru Ciolac ◽  
Bogdan Pintea ◽  
Martin Glaser ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Clinical Applications ◽  
Deep Brain

Segmentation of Target Nuclei in Parkinson's Disease Based on Fuzzy Connectedness

2013 ◽  
Vol 346 ◽  
pp. 109-115 ◽  
Author(s):  
Yan Qing Xue ◽  
Chun Lan Yang ◽  
Shui Cai Wu ◽  
Hong Jian Gao ◽  
Wang Sheng Lu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Current Treatment ◽  
Clinical Applications ◽  
Experimental Results ◽  
Stereotactic Surgery ◽  
Tree Model ◽  
Fuzzy Connectedness ◽  
Accurate Localization ◽  
Dependence Tree

With the development of nerve stereotactic technology, brain stereotactic surgery has become an effective method for the current treatment of Parkinson's disease. The accurate localization of the target nuclei is the key issue of the treatment. In this paper, we constructed a dependence tree model to identify the target nuclei further. Theory of fuzzy connectedness was used in the segmentation. Experimental results show it was more desirable and suitable to the clinical applications.

Non-linear dynamical analysis of multichannel EEG: Clinical applications in dementia and Parkinson's disease

1994 ◽  
Vol 7 (2) ◽  
pp. 141-150 ◽  
Author(s):  
Kees J. Stam ◽  
D�nes L. J. Tavy ◽  
Brechtje Jelles ◽  
Herbert A. M. Achtereekte ◽  
Joris P. J. Slaets ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Applications ◽  
Dynamical Analysis ◽  
Non Linear ◽  
Multichannel Eeg

Clinical Applications of rTMS in Parkinson’s Disease

2015 ◽  
pp. 129-145 ◽  
Author(s):  
Yuichiro Shirota ◽  
Masashi Hamada ◽  
Yoshikazu Ugawa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Applications

scholarly journals Parkinson's Disease and Segmental Coordination during Turning: II. Walking Turns

2013 ◽  
Vol 40 (4) ◽  
pp. 520-526 ◽  
Author(s):  
Sakineh Akram ◽  
James S. Frank ◽  
Mandar Jog
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Applications ◽  
Healthy Controls ◽  
Relative Timing ◽  
Healthy Elderly ◽  
Therapeutic Value ◽  
Angular Velocities ◽  
Segmental Coordination ◽  
Segment Reorientation

Abstract:Objective:Individuals with Parkinson's disease (PD) show poorer balance and greater incidence of falls while turning. We investigated whether a disturbance in timing and sequence of reorientation of body segments is a potential cause of turning difficulty in PD and is altered by levodopa.Methods:The sequence and timing of segmental reorientation during 45° and 90° walking turns were recorded in nineteen healthy controls and fourteen individuals with PD “off” and “on” medication.Results:Both healthy elderly and PD patients “off” medication displayed a top-down sequence of segment reorientation, but differed with respect to the delay time between segments: PD “off” medication displayed a shorter delay between the onset of head and shoulder reorientation and longer delays for pelvis and foot reorientation. Furthermore, for all segments the peak angular velocities were lower for PD patients than healthy controls, with greater difference between the two groups during larger turns. While for both groups the velocity and magnitude of rotation of all segments were greater during larger turns, the relative timing of reorientation of segments remained the same during small and large turns. Medication had no significant effect on the timing and sequence of reorientation of segments and caused only a small and non-significant increase to segment velocities.Conclusion:This study further characterized the turning performance of individuals with PD. Our findings have clinical applications and therapeutic value for PD patients with difficulty turning. Understanding the specific deficiencies of turning performance of PD patients allows the therapists to opt for the most effective rehabilitation techniques.

Clinical applications of neurotoxin injections in Parkinson's disease and parkinson-plus syndromes: Experience of a neurology department

Toxicon ◽  
2016 ◽  
Vol 123 ◽  
pp. S83
Author(s):  
Ana Graça Velon ◽  
Michel Mendes ◽  
Ricardo Almendra ◽  
Vera Barbosa ◽  
Ana Rita Raimundo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Applications
Sign in / Sign up

Export Citation Format

Share Document