scholarly journals Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome

2011 ◽  
Vol 26 (3) ◽  
pp. 516-519 ◽  
Author(s):  
Qinbo Yang ◽  
Lin Li ◽  
Rong Yang ◽  
Gong-Qing Shen ◽  
Qiuyun Chen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Restless Legs Syndrome ◽  
Association Studies ◽  
Population Based ◽  
Restless Legs ◽  
Family Based

scholarly journals Case–Parent Trio Studies in Cleft Lip and Palate

2020 ◽  
Vol 07 (03) ◽  
pp. 075-079
Author(s):  
Mahamad Irfanulla Khan ◽  
Prashanth CS
Keyword(s):  
Genetic Variants ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Association Studies ◽  
Geographical Location ◽  
Genetic Association Studies ◽  
Population Based ◽  
Genome Wide Association Studies ◽  
Family Based ◽  
Study Designs

AbstractCleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations in humans involving various genetic and environmental risk factors. The prevalence of CL/P varies according to geographical location, ethnicity, race, gender, and socioeconomic status, affecting approximately 1 in 800 live births worldwide. Genetic studies aim to understand the mechanisms contributory to a phenotype by measuring the association between genetic variants and also between genetic variants and phenotype population. Genome-wide association studies are standard tools used to discover genetic loci related to a trait of interest. Genetic association studies are generally divided into two main design types: population-based studies and family-based studies. The epidemiological population-based studies comprise unrelated individuals that directly compare the frequency of genetic variants between (usually independent) cases and controls. The alternative to population-based studies (case–control designs) includes various family-based study designs that comprise related individuals. An example of such a study is a case–parent trio design study, which is commonly employed in genetics to identify the variants underlying complex human disease where transmission of alleles from parents to offspring is studied. This article describes the fundamentals of case–parent trio study, trio design and its significances, statistical methods, and limitations of the trio studies.

Association between restless legs syndrome and hypertension: a meta-analysis of nine population-based studies

2017 ◽  
Vol 39 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Yaoyao Shen ◽  
Hailing Liu ◽  
Tingmin Dai ◽  
Yanqin Guan ◽  
Jianglong Tu ◽  
...  
Keyword(s):  
Restless Legs Syndrome ◽  
Meta Analysis ◽  
Population Based ◽  
Restless Legs
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