Cerebrospinal fluid tau and phosphorylated tau protein are elevated in corticobasal syndrome

2010 ◽  
Vol 26 (1) ◽  
pp. 169-173 ◽  
Author(s):  
M.B. Aerts ◽  
R.A.J. Esselink ◽  
B.R. Bloem ◽  
M.M. Verbeek
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Corticobasal Syndrome ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein

O5-04-05: Aerobic exercise reduces phosphorylated tau protein in cerebrospinal fluid in older adults with mild cognitive impairment

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P324-P324 ◽  
Author(s):  
Laura D. Baker ◽  
Jeannine S. Skinner ◽  
Suzanne Craft ◽  
Kaycee M. Sink ◽  
Thomas Montine ◽  
...  
Keyword(s):  
Older Adults ◽  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Aerobic Exercise ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein

scholarly journals Folate and Methylation Status in Relation to Phosphorylated Tau Protein(181P) and β-Amyloid(1–42) in Cerebrospinal Fluid

2007 ◽  
Vol 53 (6) ◽  
pp. 1129-1136 ◽  
Author(s):  
Rima Obeid ◽  
Mariz Kasoha ◽  
Jean-Pierre Knapp ◽  
Panagiotis Kostopoulos ◽  
George Becker ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Neurological Diseases ◽  
Methylation Status ◽  
Age Groups ◽  
Phosphorylated Tau ◽  
Β Amyloid ◽  
Folate And Vitamin B12 ◽  
The Brain ◽  
Phosphorylated Tau Protein

Abstract Background: Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. Methods: We evaluated concentrations of tHcy, S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM), folate, and vitamin B12 in cerebrospinal fluid (CSF) and plasma or serum from 182 patients with different neurological disorders. We measured concentrations of phosphorylated tau protein (P-tau)(181P) and β-amyloid(1–42) in the CSF. Results: Aging was associated with higher concentrations of tHcy and SAH in the CSF, in addition to lower concentrations of CSF folate and lower SAM:SAH ratio. Concentrations of CSF SAH and CSF folate correlated significantly with those of P-tau (r = 0.46 and r = −0.28, respectively). Moreover, P-tau correlated negatively with SAM:SAH ratio (r = −0.40, P <0.001). The association between SAH and higher P-tau was observed in 3 age groups (<41, 41–60, and >60 years). CSF tHcy was predicted by concentrations of CSF cystathionine (β = 0.478), folate (β = −0.403), albumin (β = 0.349), and age (β = 0.298). Conclusions: tHcy concentration in the brain is related to age, B vitamins, and CSF albumin. Increase of CSF SAH is related to increased CSF P-tau; decreased degradation of P-tau might be a plausible explanation. Disturbed methyl group metabolism may be the link between hyperhomocysteinemia and neurodegeneration. Lowering tHcy and SAH might protect the brain by preventing P-tau accumulation.

Phosphorylated tau protein in cerebrospinal fluid is elevated in Alzheimer's disease and other tauopathies

2000 ◽  
Vol 21 ◽  
pp. 155
Author(s):  
Katsuya Urakami ◽  
Hiroyuki Arai ◽  
Koichi Ishiguro ◽  
Hideto Ohno ◽  
Hideki Kohno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein

Cerebrospinal fluid ratio of phosphorylated tau protein and beta amyloid predicts amyloid PET positivity

2020 ◽  
Vol 83/116 (2) ◽  
pp. 173-179
Author(s):  
Jiří Cerman ◽  
Jan Laczó ◽  
Martin Vyhnálek ◽  
Jana Malinovská ◽  
Jitka Hanzalová ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Tau Protein ◽  
Beta Amyloid ◽  
Amyloid Pet ◽  
Phosphorylated Tau ◽  
Phosphorylated Tau Protein

scholarly journals Biochemical Diagnosis of Alzheimer Disease by Measuring the Cerebrospinal Fluid Ratio of Phosphorylated tau Protein to β-Amyloid Peptide42

2003 ◽  
Vol 60 (9) ◽  
Author(s):  
Alessia Maddalena ◽  
Andreas Papassotiropoulos ◽  
Britta Müller-Tillmanns ◽  
Hans H. Jung ◽  
Thomas Hegi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Alzheimer Disease ◽  
Tau Protein ◽  
Phosphorylated Tau ◽  
Biochemical Diagnosis ◽  
Β Amyloid ◽  
Phosphorylated Tau Protein
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