Olfactory dysfunction in Japanese patients with idiopathic REM sleep behavior disorder: Comparison of data using the university of Pennsylvania smell identification test and odor stick identification test for Japanese

2010 ◽  
Vol 25 (10) ◽  
pp. 1524-1526 ◽  
Author(s):  
Tomoyuki Miyamoto ◽  
Masayuki Miyamoto ◽  
Masaoki Iwanami ◽  
Koichi Hirata
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Japanese Patients ◽  
Olfactory Dysfunction ◽  
University Of Pennsylvania ◽  
Sleep Behavior ◽  
Identification Test ◽  
The University ◽  
Smell Identification

scholarly journals Alpha-synuclein seeds in olfactory mucosa of patients with isolated rapid-eye-movement sleep behaviour disorder

2020 ◽  
Author(s):  
Ambra Stefani ◽  
Alex Iranzo ◽  
Evi Holzknecht ◽  
Daniela Perra ◽  
Matilde Bongianni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Olfactory Mucosa ◽  
Behaviour Disorder ◽  
Sleep Behavior ◽  
Sleep Behaviour ◽  
The University

ABSTRACTIsolated REM sleep behaviour disorder is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of isolated REM sleep behaviour disorder patients may identify those progressing to Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal of testing preventive therapies. Real-Time Quaking-Induced Conversion (RT-QuIC) provided evidence of α-synuclein seeding activity in cerebrospinal fluid and olfactory mucosa of patients with α-synucleinopathies. Aim of this study was to explore RT-QuIC detection of α-synuclein aggregates in olfactory mucosa of large cohort of subjects with isolated REM sleep behavior disorder compared to Parkinson’s disease and controls.This cross-sectional case-control study was performed at the Medical University of Innsbruck, Austria, the Hospital Clinic de Barcelona, Spain, and the University of Verona, Italy. Olfactory mucosa samples obtained by nasal swab in 63 patients with isolated REM sleep behavior disorder, 41 matched Parkinson’s disease patients and 59 matched controls were analysed by α-synuclein RT-QuIC in a blinded fashion at the University of Verona, Italy. Median age of isolated REM sleep behavior disorder patients was 70 years, 85.7% were male. All participants were tested for smell, autonomic, cognitive and motor functions.Olfactory mucosa was α-synuclein RT-QuIC positive in 44.4% isolated REM sleep behavior disorder patients, 46.3% Parkinson’s disease and 10.2% controls. While the sensitivity for isolated REM sleep behavior disorder plus Parkinson’s disease versus controls was 45.2%, specificity was high (89.8%). Among isolated REM sleep behavior disorder patients with positive α-synuclein RT-QuIC, 78.6% had olfactory dysfunction compared to 21.4% with negative α-synuclein RT-QuIC, p<0.001. The extent of olfactory dysfunction was more severe in positive than negative α-synuclein RT-QuIC olfactory mucosa isolated REM sleep behavior disorder patients (p<0.001).We provide evidence that α-synuclein RT-QuIC assay enables the molecular detection of neuronal α-synuclein aggregates in olfactory mucosa of patients with isolated REM sleep behavior disorder and Parkinson’s disease. Although the overall sensitivity was moderate in this study, nasal swabbing is attractive as simple, non-invasive test and might be useful as part of a screening battery to identify subjects in the prodromal stages of α-synucleinopathies. Further studies are needed to enhance sensitivity, and better understand the temporal dynamics of α-synuclein seeding in the olfactory mucosa and spreading to other brain areas during the progression from isolated REM sleep behavior disorder to overt α-synucleinopathy, as well the impact of timing, disease subgroups and sampling technique on the overall sensitivity.

Odor identification test as an indicator of idiopathic REM sleep behavior disorder

2009 ◽  
Vol 24 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Tomoyuki Miyamoto ◽  
Masayuki Miyamoto ◽  
Masaoki Iwanami ◽  
Keisuke Suzuki ◽  
Yuichi Inoue ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Odor Identification ◽  
Sleep Behavior ◽  
Identification Test

scholarly journals Prevalence of olfactory dysfunction in COVID-19 patients

2021 ◽  
Author(s):  
Mohammad Bayat ◽  
Amirmohammad Arabi ◽  
Amirali Assadi ◽  
Saina Nezami Nia ◽  
Masoud Mortezazadeh ◽  
...  
Keyword(s):  
Normal Population ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
University Of Pennsylvania ◽  
Infected People ◽  
Screening Programs ◽  
Identification Test ◽  
Back Ground ◽  
The University ◽  
Smell Identification

Back ground: Nowadays COVID-19 has become a pandemic in which global society experience multiple difficulties in management. It seems that olfactory dysfunction is one of the early occurring symptoms of this viral infection and many patients just show this symptom after they got infected. Considering so, olfactory dysfunction especially a decline in olfaction could potentially be used for screening purposes and preventing the disease to spread. Methods: 50 PCR-verified SARS-CoV-2 infected participants were assessed about their olfactory function adequacy using a Modified Version of the University of Pennsylvania Smell Identification Test (UPSIT) for the Iranian population called Iran Smell Identification Test (Iran-SIT). Participants scores were compared against normal population scores in this test and possible correlations of age and scores were explored as well Results: Participants with SARS-CoV-2 infection generally obtained lesser scores in the mentioned test which means they experience a decline in olfactory function more, significantly. Aging also has a negative correlation with olfaction adequacy. Conclusion: Based on this article’s finding, olfactory function decrease is more frequent among SARS-CoV-2 infected people and potentially could be a suggestive indicator for screening programs. This indicator should be interpreted concerning patients’ age.

Olfactory dysfunction in idiopathic REM sleep behavior disorder

2010 ◽  
Vol 11 (5) ◽  
pp. 458-461 ◽  
Author(s):  
Tomoyuki Miyamoto ◽  
Masayuki Miyamoto ◽  
Masaoki Iwanami ◽  
Koichi Hirata ◽  
Mina Kobayashi ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Olfactory Dysfunction ◽  
Sleep Behavior
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