Changes in apraxia after deep brain stimulation of the nucleus basalis Meynert in a patient with Parkinson dementia syndrome

2010 ◽  
Vol 25 (10) ◽  
pp. 1519-1520 ◽  
Author(s):  
Thomas T. Barnikol ◽  
Norbert B. A. Pawelczyk ◽  
Utako B. Barnikol ◽  
Jens Kuhn ◽  
Doris Lenartz ◽  
...  
2009 ◽  
Vol 66 (6) ◽  
Author(s):  
Hans-Joachim Freund ◽  
Jens Kuhn ◽  
Doris Lenartz ◽  
Jürgen K. Mai ◽  
Thomas Schnell ◽  
...  

2014 ◽  
Vol 20 (3) ◽  
pp. 353-360 ◽  
Author(s):  
J Kuhn ◽  
K Hardenacke ◽  
D Lenartz ◽  
T Gruendler ◽  
M Ullsperger ◽  
...  

2019 ◽  
Vol 47 (1-2) ◽  
pp. 19-28 ◽  
Author(s):  
Cristina Nombela ◽  
Andrés Lozano ◽  
Clara Villanueva ◽  
Juan A. Barcia

Background/Aim: The prevalence of cognitive symptoms in recently diagnosed Parkinson’s disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms. Methods: A PD patient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere. Results: Compared to baseline, 2-month follow-up after GPi stimulation was associated with motor improvements, whereas partial improvements in cognitive functions were observed 3 months after the addition of NBM stimulation to GPi stimulation. Conclusion: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.


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