Glucocerebrosidase Gene L444P mutation is a risk factor for Parkinson's disease in Chinese population

2010 ◽  
Vol 25 (8) ◽  
pp. 1005-1011 ◽  
Author(s):  
Qi-Ying Sun ◽  
Ji-Feng Guo ◽  
Lei Wang ◽  
Ren-He Yu ◽  
Xing Zuo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Factor ◽  
Chinese Population ◽  
Glucocerebrosidase Gene ◽  
L444p Mutation

scholarly journals Genetic Analysis of LRRK2 R1628P in Parkinson’s Disease in Asian Populations

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yuan Zhang ◽  
Qiying Sun ◽  
Minhan Yi ◽  
Xun Zhou ◽  
Jifeng Guo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Factor ◽  
Chinese Population ◽  
Genetic Factors ◽  
Meta Analysis ◽  
Asian Population ◽  
High Quality ◽  
Asian Populations ◽  
Risk Variants

Although the etiology of Parkinson’s disease (PD) remains unclear, there is increasing evidence of genetic factors contributing to the onset of PD. Various mutations and risk variants of the gene LRRK2 have been reported, but the association between LRRK2 R1628P and PD is still inconsistent. Thus, we conducted a meta-analysis to determine the potential relationship between R1628P and PD. Our study sample was an aggregate of 17 publications, which in total consisted of 9,275 PD patients and 8,114 controls. All of these articles are of high quality according to NOS, and there was no obvious reporting bias or heterogeneity. In a general Asian population, the pooled OR of the risk genotype contrasts was 1.83 (95% CI: 1.57, 2.13). When stratified by ethnicity, the pooled ORs were 1.84 (95% CI: 1.56, 2.18) in a Chinese population and 1.79 (95% CI: 1.27, 2.52) in a non-Chinese population. Our study suggests that LRRK2 R1628P appears to be a risk factor for PD in Asian populations, both Chinese and non-Chinese.

scholarly journals The LRRK2 Arg1628Pro variant is a risk factor for Parkinson’s disease in the Chinese population

Neurogenetics ◽  
2008 ◽  
Vol 9 (4) ◽  
pp. 271-276 ◽  
Author(s):  
Chin-Song Lu ◽  
Yah-Huei Wu-Chou ◽  
Marina van Doeselaar ◽  
Erik J. Simons ◽  
Hsiu-Chen Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Factor ◽  
Chinese Population

scholarly journals Glucocerebrosidase Gene Mutations Associated with Parkinson's Disease: A Meta-Analysis in a Chinese population

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115747 ◽  
Author(s):  
Jia Chen ◽  
Wei Li ◽  
Tao Zhang ◽  
Yan-jiang Wang ◽  
Xiao-jiang Jiang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Population ◽  
Meta Analysis ◽  
Gene Mutations ◽  
Glucocerebrosidase Gene

Prevalence of Parkinson's disease in a Chinese population

2003 ◽  
Vol 109 (3) ◽  
pp. 228-231 ◽  
Author(s):  
J. Woo ◽  
E. Lau ◽  
E. Ziea ◽  
D. K. Y. Chan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Population

scholarly journals Evaluation of novel Parkinson's disease candidate genes in the Chinese population

2019 ◽  
Vol 74 ◽  
pp. 235.e1-235.e4 ◽  
Author(s):  
Elaine Guo Yan Chew ◽  
Herty Liany ◽  
Louis C.S. Tan ◽  
Wing-Lok Au ◽  
Kumar-M. Prakash ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Candidate Genes ◽  
Chinese Population

Glucocerebrosidase gene mutation in Parkinson’s disease

2018 ◽  
Vol 46 ◽  
pp. e15
Author(s):  
M. Macas ◽  
E.Y. Ng ◽  
M. Parimelalagan ◽  
E.K. Tan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gene Mutation ◽  
Glucocerebrosidase Gene

Four novel rare mutations of PLA2G6 in Chinese population with Parkinson's disease

2013 ◽  
Vol 19 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Ya-Xing Gui ◽  
Zhong-Ping Xu ◽  
Wen-Lv ◽  
Hong-mei Liu ◽  
Jin-Jia Zhao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Population ◽  
Rare Mutations
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