The Montreal Cognitive Assessment as a screening tool for cognitive dysfunction in Huntington's disease

2010 ◽  
Vol 25 (3) ◽  
pp. 401-404 ◽  
Author(s):  
Aleksandar Videnovic ◽  
Bryan Bernard ◽  
Wenqing Fan ◽  
Jeana Jaglin ◽  
Sue Leurgans ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Dysfunction ◽  
Cognitive Assessment ◽  
Screening Tool ◽  
Montreal Cognitive Assessment

Validity of the Montreal Cognitive Assessment in the Detection of Cognitive Dysfunction in Huntington's Disease

2012 ◽  
Vol 20 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Ondrej Bezdicek ◽  
Veronika Majerova ◽  
Marek Novak ◽  
Tomas Nikolai ◽  
Evzen Ruzicka ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Dysfunction ◽  
Cognitive Assessment ◽  
Montreal Cognitive Assessment

scholarly journals Usefulness of the Montreal Cognitive Assessment (MoCA) in Huntington's disease

2013 ◽  
Vol 28 (12) ◽  
pp. 1744-1747 ◽  
Author(s):  
Shea Gluhm ◽  
Jody Goldstein ◽  
Daniel Brown ◽  
Charles Van Liew ◽  
Paul E. Gilbert ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Assessment ◽  
Montreal Cognitive Assessment

scholarly journals Evaluation of the Montreal Cognitive Assessment as a screening tool for cognitive dysfunction in SLE

2021 ◽  
Vol 8 (1) ◽  
pp. e000580
Author(s):  
Sudha Raghunath ◽  
Yifat Glikmann-Johnston ◽  
Eric Morand ◽  
Julie C Stout ◽  
Alberta Hoi
Keyword(s):  
Cognitive Impairment ◽  
Diagnostic Accuracy ◽  
Cognitive Dysfunction ◽  
Predictive Value ◽  
Cognitive Assessment ◽  
Screening Tool ◽  
Cognitive Testing ◽  
Montreal Cognitive Assessment ◽  
Cognitive Test ◽  
Receiver Operating Curve

ObjectivesCognitive dysfunction in SLE is common and associated with significant morbidity but is currently underdetected. Early detection requires the use of screening tests, as formal diagnostic cognitive testing is time-consuming. This study aims to evaluate the Montreal Cognitive Assessment (MoCA) as a screening tool for cognitive dysfunction in SLE.MethodsPatients with SLE (n=95) and demographically matched healthy control participants (n=48) underwent cognitive testing using the 1-hour neuropsychiatric test battery recommended by the American College of Rheumatology for use in SLE and the MoCA. We used regression analyses to determine associations between MoCA and cognitive test scores. We assessed several MoCA cut-offs for predicting cognitive impairment in terms of sensitivity, specificity, positive predictive value and negative predictive value. Receiver operating curve analyses were used to determine the diagnostic accuracy of the MoCA cut-off thresholds.ResultsWe found a significant correlation between MoCA score and 9 of the 10 cognitive endpoints studied (all p<0.001). Receiver operating curve analysis suggested that a MoCA cut-off of <27 had highest diagnostic accuracy across the cognitive impairment definitions (area under the curve 0.76–0.78). Using a screening cut-off of <28, the MoCA had sensitivity of 83%–94% and specificity of 46%–59%, depending on the impairment definition used.ConclusionsThe MoCA correlates strongly with cognitive test results in SLE and has sufficient sensitivity for use as a screening tool with a cut-off of <28 as the optimal threshold. This tool can be incorporated into clinical practice for screening for cognitive dysfunction in SLE.

Montreal cognitive assessment for evaluating cognitive impairment in Huntington’s disease: a systematic review

CNS Spectrums ◽  
2020 ◽  
pp. 1-19
Author(s):  
Elena Cecilia Rosca ◽  
Mihaela Simu
Keyword(s):  
Cognitive Impairment ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Assessment ◽  
Cognitive Status ◽  
Montreal Cognitive Assessment ◽  
Cutoff Score ◽  
Index Test ◽  
Cross Sectional ◽  
Cross Sectional Studies

Abstract Objective This study aims to systematically review evidence of the accuracy of the Montreal Cognitive Assessment (MoCA) for evaluating the presence of cognitive impairment in patients with Huntington’s disease (HD) and to outline the quality and quantity of research evidence available about the use of the MoCA in this population. Methods We conducted a systematic literature review, searching four databases from inception until April 2020. Results We identified 26 studies that met the inclusion criteria: two case–control studies comparing the MoCA to a battery of tests, three studies comparing MoCA to Mini-Mental State Examination, two studies estimating the prevalence of cognitive impairment in individuals with HD and 19 studies or clinical trials in which the MoCA was used as an instrument for the cognitive assessment of participants with HD. We found no cross-sectional studies in which participants received the index test (MoCA) and a reference standard diagnostic assessment composed of an extensive neuropsychological battery. The publication period ranged from 2010 to 2020. Conclusions In patients with HD, the MoCA provides information about disturbances in general cognitive function. Even if the MoCA demonstrated good sensitivity and specificity when used at the recommended threshold score of 26, further cross-sectional studies are required to examine the optimum cutoff score for detecting cognitive impairments in patients with HD. Moreover, more studies are necessary to determine whether the MoCA adequately assesses cognitive status in individuals with HD.

Plasma Cytokine Levels in Relation to Neuropsychiatric Symptoms and Cognitive Dysfunction in Huntington’s disease

2016 ◽  
Vol 5 (4) ◽  
pp. 369-377 ◽  
Author(s):  
Jos A. Bouwens ◽  
Erik van Duijn ◽  
Christa M. Cobbaert ◽  
Raymund A.C. Roos ◽  
Roos C. van der Mast ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Dysfunction ◽  
Neuropsychiatric Symptoms ◽  
Plasma Cytokine ◽  
Cytokine Levels

Hubungan Kadar Prokalsitonin dan Kejadian Postoperative Cognitive Disfunction (POCD) ada Pasien yang Menjalani Operasi Ganti Katup Jantung Di Rumah Sakit Umum Pusat Dr. Kariadi Semarang

2021 ◽  
Vol 13 (3) ◽  
pp. 153-164
Author(s):  
Widya Istanto Nurcahyo ◽  
Ari Kurniawan ◽  
Yulia Wahyu Villyastuti ◽  
Taufik Eko Nugroho ◽  
Satrio Adi Wicaksono ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Cognitive Assessment ◽  
Montreal Cognitive Assessment ◽  
Cross Sectional ◽  
Consecutive Sampling

Latar belakang:Postoperative cognitive dysfunction atau POCD adalah gangguan fungsi kognitif akibat inflamasi pasca prosedur pembedahan. Angka kejadian POCD pasca pembedahan kardiak lebih tinggi dibandingkan pembedahan non-kardiak. POCD diduga diakibatkan oleh respons inflamasi sistemik. Prokalsitonin menjadi salah satu mediator inflamasi yang berperan terhadap peningkatan risiko inflamasi saat operasi yang memicu kejadian POCD pascaoperasi ganti katup jantung. Inflamasi disebabkan oleh pelepasan protein fase akut yaitu prokalsitonin dan sitokin proinflamasi lainnya yang menyebabkan terganggunya sawar darah otak dan mengganggu neurotransmisi sehingga terjadi POCD.Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan peningkatan kadar Prokalsitonin terhadap POCD pada pasien yang menjalani operasi ganti katup jantung di RSUP Dr. Kariadi.Metode: Penelitian ini adalah penelitian analitik observasional dengan pendekatan cross sectional. Populasi penelitian ini adalah seluruh pasien yang menjalani operasi ganti katup jantung di RSUP Dr. Kariadi pada bulan Juni 2020- Desember 2020. Sampel penelitian sebanyak 19 subjek didapatkan dengan teknik consecutive sampling. Pada subjek penelitian dilakukan pengukuran kadar serum prokalsitonin sebelum pembedahan dan hari pertama pasca pembedahan, kemudian dilakukan pemeriksaan fungsi kognitif dengan montreal cognitive assessment-indonesia (MoCA INA) pada hari ketiga pasca pembedahan. Data dianalisis dengan uji korelasi spearman.Hasil: Dari 19 subjek penelitian, terdapat 13 responden (68,4%) yang mengalami POCD. Rerata peningkatan prokalsitonin pada pasien POCD adalah 5,22 dengan standar deviasi 12,50 sedangkan peningkatan prokalsitonin pada pasien non POCD adalah 0,21 dengan standar deviasi 0,45. Berdasarkan uji korelasi spearman, diperoleh hasil bahwa terdapat hubungan yang signifikan antara peningkatan kadar prokalsitonin terhadap POCD pascaoperasi ganti katup jantung (p=0,004).Kesimpulan: Terdapat hubungan yang signifikan antara perbedaan kadar Prokalsitonin terhadap POCD pascaoperasi ganti katup jantung di RSUP Dr. Kariadi.

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