Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson's disease

2009 ◽  
Vol 24 (15) ◽  
pp. 2203-2210 ◽  
Author(s):  
Yaroslau Compta ◽  
María J. Martí ◽  
Naroa Ibarretxe-Bilbao ◽  
Carme Junqué ◽  
Francesc Valldeoriola ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Amyloid ◽  
Neuropsychological Functions

IC-P-074: Cerebrospinal Tau, Phospho-Tau, and Beta-Amyloid and Neuropsychological Functions in Alzheiemer' Disease and Parkinson's Disease

2010 ◽  
Vol 6 ◽  
pp. S32-S32
Author(s):  
Elka Stefanova ◽  
Gorana Mandic ◽  
Ivanka Markovic ◽  
Tanja Stojkovic ◽  
Milica Jecmenica-Lukic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Amyloid ◽  
Neuropsychological Functions

scholarly journals Neuropsychological Functions and SPECT Neuroimaging in Parkinson’s Disease

10.5772/17948 ◽  
2011 ◽  
Author(s):  
Lambros Messinis ◽  
Athanasios Papathanasiou ◽  
Epameinondas Lyros ◽  
George Gatzounis ◽  
Panagiotis Papathanasopoulos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuropsychological Functions

P01-72 - Depression and neuropsychological functions in different stages of Parkinson's disease

2010 ◽  
Vol 25 ◽  
pp. 293
Author(s):  
L. Messinis ◽  
E. Lyros ◽  
T. Papathanasiou ◽  
V. Andrian ◽  
P. Papathanasopoulos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuropsychological Functions

Single Electrode and Multiple Electrode Guided Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease

2007 ◽  
Vol 61 (suppl_5) ◽  
pp. ONS346-ONS357 ◽  
Author(s):  
Yasin Temel ◽  
Poldi Wilbrink ◽  
Annelien Duits ◽  
Peter Boon ◽  
Selma Tromp ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Advanced Parkinson’S Disease ◽  
Implanted Electrodes ◽  
Risk Of Bleeding ◽  
Electrophysiological Recordings ◽  
Multiple Electrodes ◽  
Neuropsychological Functions ◽  
Stn Dbs

Abstract Objective: It is still debated to what extent intraoperative electrophysiological techniques contribute to the outcome of subthalamic nucleus (STN) deep brain stimulation (DBS). Intraoperative electrophysiological recordings for identification of the STN can be made with one electrode or with multiple, simultaneously implanted electrodes. The latter provide more detailed information about the electrophysiological boundaries of the STN; however, implantation of several electrodes at one time might increase the risk of bleeding. Here we report the results of a study of patients with advanced Parkinson's disease, in which one group of patients underwent bilateral STN DBS with electrophysiological recordings from a single electrode, and the other group received STN DBS with multiple (five or fewer) simultaneously implanted electrodes. Patients and Methods: Fifty-five patients suffering from advanced Parkinson's disease who underwent bilateral STN stimulation were included in this study. Thirty-two patients underwent STN DBS guided by a single semi-microelectrode, and 23 patients underwent STN DBS guided with simultaneously implanted multiple microelectrodes. All patients were examined preoperatively and 3 and 12 months postoperatively with regard to activities of daily living, motor functions, and neuropsychological functions. Results: We found that the simultaneous implantation of multiple electrodes does not increase the risk of bleeding or any other major intracranial complication. The use of multiple electrodes resulted in better motor results when compared with patients who underwent STN DBS guided with a single recording electrode. There were significantly more improvements in patients’ tremor and rigidity, and as a consequence, a better total Unified Parkinson Disease Rating Scale, Part III score was identified during the medication-off phase. Despite better motor effects, patients treated with multiple electrodes showed subtle deterioration in neuropsychological functions, particularly in memory function. Conclusion: STN DBS performed with multiple electrophysiological recording electrodes resulted in better motor outcome but induced specific mild declines in neuropsychological functions.

scholarly journals Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Tracy R. Melzer ◽  
Megan R. Stark ◽  
Ross J. Keenan ◽  
Daniel J. Myall ◽  
Michael R. MacAskill ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Beta Amyloid ◽  
Amyloid Deposition

Stereotactic Lesion in the Forel's Field H: A 2-Years Prospective Open-Label Study on Motor and Nonmotor Symptoms, Neuropsychological Functions, and Quality of Life in Parkinson Disease

Neurosurgery ◽  
2019 ◽  
Vol 85 (4) ◽  
pp. E650-E659 ◽  
Author(s):  
Fabio Godinho ◽  
Michel Magnin ◽  
Paulo Terzian Filho ◽  
Paul Reis ◽  
Osmar Moraes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Global Health ◽  
Parkinson Disease ◽  
Rating Scale ◽  
Nonmotor Symptoms ◽  
Neuropsychological Functions ◽  
Forel's Field H

Abstract BACKGROUND Stereotactic lesion in the Forel's field H (campotomy) was proposed in 1963 to treat Parkinson disease (PD) symptoms. Despite its rationale, very few data on this approach have emerged. Additionally, no study has assessed its effects on nonmotor symptoms, neuropsychological functions and quality of life. OBJECTIVE To provide a prospective 2-yr assessment of motor, nonmotor, neuropsychological and quality of life variables after unilateral campotomy. METHODS Twelve PD patients were prospectively evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS), the Dyskinesia Rating Scale and the Parkinson's disease quality of life questionnaire (PDQ39) before campotomy, and after 6 and 24 mo. Nonmotor, neuropsychiatric, neuropsychological and quality of life variables were assessed. The impact of PD on global health was also rated. RESULTS A significant reduction in contralateral rest tremor (65.7%, P < .001), rigidity (87.8%, P < .001), bradykinesia (68%, P < .001) and axial symptoms (24.2%, P < .05) in offmedication condition led to a 43.9% reduction in UPSDRS III scores 2 yr after campotomy (P < .001). Gait improved by 31.9% (P < .05) and walking time to cover 7 m was reduced by 43.2% (P < .05). Pain decreased by 33.4% (P < .01), while neuropsychiatric and neuropsychological functions did not change. Quality of life improved by 37.8% (P < .05), in line with a 46.7% reduction of disease impact on global health (P < .001). CONCLUSION A significant 2-yr improvement of motor symptoms, gait performance and pain was obtained after unilateral campotomy without significant changes to cognition. Quality of life markedly improved in parallel with a significant reduction of PD burden on global health.

scholarly journals Beta-Amyloid, Phospho-Tau and Alpha-Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease Patients

2013 ◽  
Vol 24 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Cheng-Ying Ho ◽  
Juan C. Troncoso ◽  
David Knox ◽  
Walter Stark ◽  
Charles G. Eberhart
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Amyloid ◽  
Alpha Synuclein ◽  
The Brain

Network Patterns of Beta-Amyloid Deposition in Parkinson’s Disease

2019 ◽  
Vol 56 (11) ◽  
pp. 7731-7740 ◽  
Author(s):  
Jinhee Kim ◽  
Christine Ghadery ◽  
Sang Soo Cho ◽  
Alexander Mihaescu ◽  
Leigh Christopher ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Amyloid ◽  
Amyloid Deposition ◽  
Network Patterns

SPECT neuroimaging and neuropsychological functions in different stages of Parkinson’s disease

2010 ◽  
Vol 37 (6) ◽  
pp. 1128-1140 ◽  
Author(s):  
Anna Paschali ◽  
Lambros Messinis ◽  
Odysseas Kargiotis ◽  
Velissarios Lakiotis ◽  
Zinovia Kefalopoulou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuropsychological Functions

P4-308: CSF α-synuclein, BETA-AMYLOID 1-42 and tau proteins: Relationship to clinical parameters in early Parkinson's disease

2012 ◽  
Vol 8 (4S_Part_21) ◽  
pp. S766-S767
Author(s):  
Ju Hee Kang ◽  
Alice Chen-Plotkin ◽  
David Irwin ◽  
Andrew Siderowf ◽  
Chelsea Caspell ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Amyloid ◽  
Tau Proteins ◽  
Clinical Parameters ◽  
Early Parkinson’S Disease
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