Weight loss, body fat mass, and leptin in Parkinson's disease

2009 ◽  
Vol 24 (6) ◽  
pp. 885-890 ◽  
Author(s):  
Birgitta Lorefält ◽  
Göran Toss ◽  
Ann-Kathrine Granérus
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Parkinson's Disease ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass

scholarly journals Altered Body Composition and Increased Resting Metabolic Rate Associated with the Postural Instability/Gait Difficulty Parkinson’s Disease Subtype

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Giovana Femat-Roldán ◽  
María Andrea Gaitán Palau ◽  
Inma Castilla-Cortázar ◽  
Georgina Elizondo Ochoa ◽  
Nancy Guadalupe Moreno ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Weight Loss ◽  
Parkinson's Disease ◽  
Metabolic Rate ◽  
Body Fat ◽  
Resting Metabolic Rate ◽  
Postural Instability ◽  
Body Fat Mass ◽  
Lower Body ◽  
Postural Instability Gait Difficulty

Background. Weight loss in Parkinson’s disease (PD) patients is a common but poorly understood manifestation. Several studies have reported that weight changes could be related to motor symptoms, drug side effects, dysphagia, depression, and/or dementia. Weight loss in PD is not a benign phenomenon and it has several clinical and prognostic implications with increased morbidity and mortality. Thus, it is crucial to determine nutritional changes in PD patients in order to prevent malnutrition and improve their quality of life. Objective. To compare body composition and resting metabolic rates between PD patients and controls. Methods. A total of 64 PD patients and 52 controls were studied. The Hoehn-Yahr scale was used to determine the disease stage, clinical and epidemiological data were recorded from verbal questionnaire, Inbody S10® was used to collect corporal parameters, and FitMate system was used to assess the resting metabolic rate. Results. No significant differences were found between both experimental groups in age, gender, height, cholesterol levels, and the presence of hypertension, diabetes, and hypo/hyperthyroidism. However, the PD group showed lower body fat mass, whole-body fat percentage, and greater resting metabolic rate compared to controls (p<0.05), with no significant differences in musculoskeletal mass. Parkinson’s disease postural instability/gait difficulty (PD-PIGD) subtype showed lower body fat parameters, increased fat-free mass, and higher resting metabolic rates. Conclusions. These results suggest that PD patients present an increased resting metabolic rate associated with the postural instability/gait difficulty PD subtype, allowing a selective decrease of body fat mass and not musculoskeletal mass. Of note, several disease-related factors may contribute to this weight loss in PD patients, being a complex and multifactorial consequence. Our findings could likely be one of the many contributing factors. However, present findings may further add to our understanding of the phenomenon of weight loss in patients with PD.

Efficacy of Orlistat 60 mg on Weight Loss and Body Fat Mass in US Army Soldiers

2012 ◽  
Vol 112 (4) ◽  
pp. 533-540 ◽  
Author(s):  
Tracey J. Smith ◽  
Aaron Crombie ◽  
LesLee Funderburk Sanders ◽  
Lori D. Sigrist ◽  
Gaston P. Bathalon ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Us Army ◽  
Army Soldiers

scholarly journals A human study to evaluate toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial

2020 ◽  
Author(s):  
Su-Jin Jung ◽  
Woo-Lim Kim ◽  
Byung-Hyun Park ◽  
Seung-Ok Lee ◽  
soowan chae
Keyword(s):  
Weight Loss ◽  
Trace Element ◽  
Body Fat ◽  
Fat Mass ◽  
Fat Free Mass ◽  
Control Group ◽  
Body Fat Mass ◽  
Restricted Diet ◽  
Fat Reduction ◽  
Toxic Trace Element

Abstract Background: Detox diet are known as a popular dieting strategies that helps toxins elimination and weight manage but there is very little clinical evidence. Methods: To evaluate the effects of 4 week intake of the Wellnessup diet (WD) on toxic trace element detoxification, body fat reduction, and safety parameters. Forty-five women with body mass index (BMI) of 23.5-30 kg/m 2 were recruited. Thirty of them were assigned 1:1 to the test group (WD, 15 subjects) and control group 1 (calorie-restricted diet, CRD, 15 subjects) in a single blind and randomized, and the remaining 15 subjects were assigned to control group 2 (maintaining regular diet, MRD). The primary outcome were toxic trace element levels in hair (29 types of heavy metals), and the secondary outcomes were changes in anthropometric and urinary organic acids. Results: The levels of four toxic trace elements in hair decreased in the WD group after the diet compared to before the diet. Ni, Rh, Sn, and Ga were significantly lower in the WD group than in the CRD or MRD group (p<0.05). A significant weight loss in both groups (WRD:-1.88±0.95kg; p<0.013, CRD:-3.22±0.48kg; p<0.01). The BMI, fat free mass and hip circumference (HC) of the CRD group were not only significantly decreased compared to the WD group but also Weight, BMI. Body fat mass, fat free mass, waist circumference, and HC were significantly decreased (p<0.05) compared to the MRD group, and the weight loss was a greater decrease was observed in the CRD group. No significant changes in any safety parameter were observed. Conclusions: Use of WD might have several beneficial effects and safety such as body fat reduction and improving some the element detoxification through caloric restriction but did not reducing body fat mass more than calorie-restricted diet.

scholarly journals Licorice Flavonoid Oil Effects Body Weight Loss by Reduction of Body Fat Mass in Overweight Subjects

2006 ◽  
Vol 52 (6) ◽  
pp. 672-683 ◽  
Author(s):  
Yuji Tominaga ◽  
Tatsumasa Mae ◽  
Mitsuaki Kitano ◽  
Yoshiro Sakamoto ◽  
Hideyuki Ikematsu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Body Fat ◽  
Fat Mass ◽  
Body Weight Loss ◽  
Body Fat Mass ◽  
Overweight Subjects

Gain without pain: beyond sport effortless exercise solutions

2020 ◽  
Vol 9 (5) ◽  
pp. 202-210
Author(s):  
Xanya Sofra
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Metabolic Rate ◽  
Body Fat ◽  
Fat Mass ◽  
Visceral Adipose Tissue ◽  
Visceral Fat ◽  
Body Fat Mass ◽  
Free T3 ◽  
Visceral Adipose

Ageing is associated with decreased metabolism, increased toxicity, decreased skeletal muscle mass (SMM) and increased visceral fat deposits that compromise the normal functioning of vital organs such as the liver, pancreas and intestines, increasing the risk of a number of health problems, including type 2 diabetes, coronary heart disease, hypertension and non-alcoholic fatty liver. Visceral adipose tissue holds large amounts of toxins that alter thyroid hormone metabolism, lowering resting metabolic rate (RMR). Strenuous physical exercise can reach these deeper visceral adipose tissue layers. However, excessive exercise is necessary to reduce visceral adipose tissue elevates cortisol while decreasing testosterone. The hormonal imbalance resulting from this inverse cortisol/testosterone relationship ultimately leads to weight gain, despite all the efforts invested in physical activity. On the other hand, lack of exercise allows for accumulation of toxicity and increased vulnerability to chronic physical disorders. Energy-based technologies report successful results in reducing subcutaneous fat layers; however, data is not currently available about methods that can reduce deeper visceral adipose tissue and relieve the system from visceral fat cells stuffed with excess triglycerides. In this study, we examined hormone and cholesterol fluctuations in the blood tests of eight subjects undergoing six 45 minutes of effortless exercise sessions with a novel London University invention. We also explored changes in their visceral adipose tissue, overall body fat mass, SMM, basic metabolic rate (BMR), waist and abdomen reduction in centimetres (cm) and overall weight loss in kilograms (kg). Subjects' results revealed a statistically significant increase in triiodothyronine (Free T3), accompanied by a significant decrease in the very low-density lipoprotein (VLDL) and triglycerides. Cortisol did not show statistically significant fluctuations. There was a statistically significant decrease in visceral adipose tissue and overall body fat mass and a statistically significant increase in SMM. Waist and abdomen cm loss, and weight loss in kgs were statistically significant, demonstrating a substantial decrease in cm and kgs in all subjects that persisted a week after the last treatment. Results of this study supported the hypothesis that this method of effortless exercise can reduce both overall body fat mass, visceral adipose tissue and VLDL, while increasing SMM and the metabolic hormone free T3, without the aid of diet or change in lifestyle.

Body fat mass and distribution as predictors of metabolic outcome and weight loss after Roux-en-Y gastric bypass

2018 ◽  
Vol 14 (7) ◽  
pp. 936-942 ◽  
Author(s):  
Daniel Eriksson Hogling ◽  
Mikael Rydén ◽  
Jesper Bäckdahl ◽  
Anders Thorell ◽  
Peter Arner ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Metabolic Outcome

Novel genes on rat chromosome 10 are linked to body fat mass, preadipocyte number and adipocyte size

2016 ◽  
Vol 11 (S 01) ◽  
Author(s):  
A Weingarten ◽  
L Turchetti ◽  
K Krohn ◽  
M Kern ◽  
I Klöting ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Adipocyte Size ◽  
Chromosome 10 ◽  
Novel Genes

1019-P: Glucagon-Like Peptide-1 Receptor Agonists Predominantly Reduce Body Fat Mass in Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1019-P
Author(s):  
YUKI FUJITA ◽  
SODAI KUBOTA ◽  
HITOSHI KUWATA ◽  
DAISUKE YABE ◽  
YOSHIYUKI HAMAMOTO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Receptor Agonists ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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