Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects

2009 ◽  
Vol 24 (2) ◽  
pp. 204-210 ◽  
Author(s):  
Lina Shehadeh ◽  
Georgia Mitsi ◽  
Nikhil Adi ◽  
Nanette Bishopric ◽  
Spyridon Papapetropoulos
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Body ◽  
Postmortem Brain ◽  
Body Protein ◽  
Control Subjects ◽  
And Control

scholarly journals Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects

2016 ◽  
Vol 6 (4) ◽  
pp. 761-770 ◽  
Author(s):  
Thomas G. Beach ◽  
Anne-Gaëlle Corbillé ◽  
Franck Letournel ◽  
Jeffrey H. Kordower ◽  
Thomas Kremer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sigmoid Colon ◽  
Alpha Synuclein ◽  
Control Subjects ◽  
Immunohistochemical Methods ◽  
And Control

scholarly journals Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan

2019 ◽  
Vol 8 (10) ◽  
pp. 1529 ◽  
Author(s):  
Kuo-Hsuan Chang ◽  
Yih-Ru Wu ◽  
Yi-Chun Chen ◽  
Hsiu-Chuan Wu ◽  
Chiung-Mei Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Age At Onset ◽  
Genetic Associations ◽  
Age And Gender ◽  
Control Subjects ◽  
Important Pathway ◽  
And Gender ◽  
And Control ◽  
First Time

Background: CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson’s disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. Methods: We investigated the effects of two functional genetic variants, including CSF1 rs1058885 and CSF1R rs10079250 in a cohort including 502 Taiwanese patients with PD and 511 age- and gender-matched healthy controls. Results: The CSF1 rs1058885 TT genotype was less frequent in PD patients compared with control subjects (odds ratio (OR) = 0.63, 95% confidence interval (CI): 0.43–0.92, p = 0.015). The PD patients also had a lower frequency of the CSF1 rs1058885 T allele compared with the control subjects (OR = 0.80, 95% CI: 0.67–0.96, p = 0.014). No statistically significant differences in allelic and genotypic frequencies of CSF1R rs10079250 between the PD and control subjects were found, even after stratification by age at onset and gender. Conclusion: This study reports a genetic association between CSF1 and PD for the first time.

scholarly journals The Effect of Pramipexole Therapy on Balance Disorder and Fall Risk in Parkinson’s Disease at Early Stage: Clinical and Posturographic Assessment

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Sibel Güler ◽  
Levent Sinan Bir ◽  
Beyza Akdag ◽  
Fusun Ardıc
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Drug Therapy ◽  
Fall Risk ◽  
Early Stage ◽  
Postural Instability ◽  
Assessment Tools ◽  
Control Subjects ◽  
Significant Difference ◽  
And Control

The aim of this study was to determine balance problems and severity and ratio of postural instability of newly diagnosed, early stage Parkinson’s patients who did not receive any antiparkinson treatment before, to evaluate fall risk clinically and posturographically and to examine the effects of pramipexole on these signs and symptoms. Detailed posturographic assessments which involved central vestibular, visual, peripheric vestibular somatosensory field tests were applied to both patient and control subjects and fall risk was determined. There was not statistically significant difference between patients and control subjects before and after drug therapy in the assesment of fall risk in posturography and there was not any improvement with drug usage in the patient group. However, in the analysis of subsystems separately, only the involvement in central vestibular field was more severe and could appear at all positions in Parkinson’s patients comparing with the control group, and pramipexole was partially effective in improving this disorder. Central vestibular field is the subsystem that should be examined with first priority. Posturography is relatively reliable in defining fall risk and postural instability ratio in Parkinson’s disease. But it should be considered that clinical assessment tools can be more sensitive in the evaluation of balance and postural disorders and in the follow-up of the response to drug therapy.

Cerebellar Norepinephrine in Patients With Parkinson's Disease and Control Subjects

1984 ◽  
Vol 41 (6) ◽  
pp. 612-614 ◽  
Author(s):  
S. J. Kish ◽  
K. S. Shannak ◽  
A. H. Rajput ◽  
J. J. Gilbert ◽  
O. Hornykiewicz
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Control Subjects ◽  
And Control

scholarly journals Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease

2019 ◽  
Author(s):  
Arlin Keo ◽  
Ahmed Mahfouz ◽  
Angela M.T. Ingrassia ◽  
Jean-Pascal Meneboo ◽  
Celine Villenet ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Body ◽  
Molecular Mechanisms ◽  
Expression Patterns ◽  
Brain Regions ◽  
Postmortem Brain ◽  
Brain Atlas ◽  
Dopamine Synthesis ◽  
Regional Vulnerability

AbstractThe molecular mechanisms underlying the caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease (PD) remain poorly understood. Here, we aimed to unravel transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological controls and PD donors. Using human postmortem brain datasets of non-neurological adults from the Allen Human Brain Atlas, we identified expression patterns related to PD progression, including genes found in PD genome-wide associations studies: SNCA, ZNF184, BAP1, SH3GL2, ELOVL7, and SCARB2. We confirmed these patterns in two datasets of non-neurological subjects (Genotype-Tissue Expression project and UK Brain Expression Consortium) and found altered patterns in two datasets of PD patients. Additionally, co-expression analysis across vulnerable regions identified two modules associated with dopamine synthesis, the motor and immune system, blood-oxygen transport, and contained microglial and endothelial cell markers, respectively. Alterations in genes underlying these region-specific functions may contribute to the selective regional vulnerability in PD brains.

Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects

Neurology ◽  
1995 ◽  
Vol 45 (4) ◽  
pp. 645-648 ◽  
Author(s):  
J. Jankovic ◽  
J. Beach ◽  
K. Schwartz ◽  
C. Contant
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Control Subjects ◽  
And Control
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