Decision making in Parkinson's disease: Analysis of behavioral and physiological patterns in the Iowa gambling task

2008 ◽  
Vol 23 (4) ◽  
pp. 547-552 ◽  
Author(s):  
Mutsutaka Kobayakawa ◽  
Shinichi Koyama ◽  
Masaru Mimura ◽  
Mitsuru Kawamura
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Iowa Gambling Task ◽  
Gambling Task ◽  
Disease Analysis

scholarly journals Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson’s Disease?

2020 ◽  
pp. 1-15
Author(s):  
Michael F. Salvatore ◽  
Isabel Soto ◽  
Helene Alphonso ◽  
Rebecca Cunningham ◽  
Rachael James ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Iowa Gambling Task ◽  
Motor Impairment ◽  
Disease Process ◽  
Strategic Decision ◽  
Strategic Decision Making ◽  
Potential Utility ◽  
Gambling Task

Up to 23% of newly diagnosed, non-demented, Parkinson’s disease (PD) patients experience deficits in executive functioning (EF). In fact, EF deficits may occur up to 39-months prior to the onset of motor decline. Optimal EF requires working memory, attention, cognitive flexibility, and response inhibition underlying appropriate decision-making. The capacity for making strategic decisions requires inhibiting imprudent decisions and are associated with noradrenergic and dopaminergic signaling in prefrontal and orbitofrontal cortex. Catecholaminergic dysfunction and the loss of noradrenergic and dopaminergic cell bodies early in PD progression in the aforementioned cortical areas likely contribute to EF deficits resulting in non-strategic decision-making. Thus, detecting these deficits early in the disease process could help identify a significant portion of individuals with PD pathology (14–60%) before frank motor impairment. A task to evaluate EF in the domain of non-strategic decision-making might be useful to indicate the moderate loss of catecholamines that occurs early in PD pathology prior to motor decline and cognitive impairment. In this review, we focus on the potential utility of the Iowa Gambling Task (IGT) for this purpose, given significant overlap between in loss of dopaminergic and noradrenergic cells bodies in early PD and the deficits in catecholamine function associated with decreased EF. As such, given the loss of catecholamines already well-underway after PD diagnosis, we evaluate the potential utility of the IGT to identify the risk of therapeutic non-compliance and a potential companion approach to detect PD in premotor stages.

Relationship between motor learning and the Iowa Gambling Task in Parkinson’s disease

2017 ◽  
Vol 381 ◽  
pp. 1044
Author(s):  
N. Ueda ◽  
Y. Higashiyama ◽  
K. Kimura ◽  
M. Okamoto ◽  
H. Joki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Learning ◽  
Iowa Gambling Task ◽  
Gambling Task

Iowa Gambling Task in patients with early-onset Parkinson’s disease: strategy analysis

2012 ◽  
Vol 33 (6) ◽  
pp. 1329-1335 ◽  
Author(s):  
Tomáš Gescheidt ◽  
Kristína Czekóová ◽  
Tomáš Urbánek ◽  
Radek Mareček ◽  
Michal Mikl ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Onset ◽  
Iowa Gambling Task ◽  
Gambling Task ◽  
Strategy Analysis ◽  
Early Onset Parkinson’S Disease

The Iowa Gambling Task in Parkinson's disease: A meta-analysis on effects of disease and medication

2016 ◽  
Vol 91 ◽  
pp. 163-172 ◽  
Author(s):  
Ricarda Evens ◽  
Michael Hoefler ◽  
Karolina Biber ◽  
Ulrike Lueken
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iowa Gambling Task ◽  
Meta Analysis ◽  
Gambling Task

Applied strategy in the Iowa Gambling Task: Comparison of individuals with Parkinson’s disease to healthy controls

2020 ◽  
Vol 42 (5) ◽  
pp. 425-435 ◽  
Author(s):  
Sophie Wohlert Kjær ◽  
Mette Buhl Callesen ◽  
Lars Larsen ◽  
Per Borghammer ◽  
Karen Østergaard ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iowa Gambling Task ◽  
Healthy Controls ◽  
Gambling Task

scholarly journals Social Cognition in Patients with Early-Onset Parkinson’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Ana Natalia Seubert-Ravelo ◽  
Ma Guillermina Yáñez-Téllez ◽  
María Lizbeth Lazo-Barriga ◽  
Alejandra Calderón Vallejo ◽  
Carlos Eduardo Martínez-Cortés ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Decision Making ◽  
Parkinson's Disease ◽  
Social Cognition ◽  
Early Onset ◽  
Emotional Processing ◽  
Iowa Gambling Task ◽  
Social Reasoning ◽  
Facial Emotion ◽  
Family Demands

Social cognition (SC) deficits have been linked to Parkinson’s disease (PD) but have been less well researched than general cognitive processes, especially in early-onset PD (EOPD), despite this population often having greater social and family demands. Most studies focus on recognition of facial emotion, theory of mind (ToM), and decision-making domains, with limited research reporting on social reasoning. The main objective of this work was to compare SC ability across four domains: emotional processing, social reasoning, ToM, and decision-making between patients with EOPD and healthy controls. Twenty-five nondemented patients with EOPD and 25 controls matched for sex, age, and educational level were enrolled. A battery that included six SC tests was administered to all study participants; a decision-making scale was completed by participants’ partners. Statistically significant differences were found between patients with EOPD and controls in all subtests across the four SC domains studied. The EOPD group demonstrated worse performance on all tasks, with large effect sizes. Differences remained significant after adjusting for Montreal Cognitive Assessment (MoCA) test scores for all SC subtests except the decision-making scale and the Iowa gambling task. No significant correlations between SC and other clinical PD variables were found. Our study shows that patients with EOPD perform significantly below controls in multiple SC domains affecting recognition of facial emotion, social reasoning, ToM, and decision-making. Only decision-making seems to be mediated by overall cognitive ability. The confounding or contributing effect of other clinical PD variables should be studied further.

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