Mood stability during acute stimulator challenge in Parkinson's disease patients under long-term treatment with subthalamic deep brain stimulation

2007 ◽  
Vol 22 (8) ◽  
pp. 1093-1096 ◽  
Author(s):  
Alexandre Berney ◽  
Michel Panisset ◽  
Abbas F. Sadikot ◽  
Alain Ptito ◽  
Alain Dagher ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Deep Brain

scholarly journals Focal Subthalamic Atrophy After Long‐Term Deep Brain Stimulation in Parkinson's Disease

2021 ◽  
Author(s):  
Ellen Gelpi ◽  
Christine Haberler ◽  
Alexander Micko ◽  
Andrea Polt ◽  
Andreas Amon ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Deep Brain

Long term mortality of patients with Parkinson’s disease treated with deep brain stimulation in a reference center

2021 ◽  
Vol 202 ◽  
pp. 106486
Author(s):  
Ana Luísa Rocha ◽  
Ana Oliveira ◽  
Cláudia Sousa ◽  
Pedro Monteiro ◽  
Maria José Rosas ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Reference Center ◽  
Deep Brain ◽  
Long Term Mortality

The prognostic value of G325R GBA mutation on the long-term deep brain stimulation outcome in Parkinson's disease

2021 ◽  
Vol 429 ◽  
pp. 119472
Author(s):  
Claudia Ledda ◽  
Carlo Alberto Artusi ◽  
Maurizio Zibetti ◽  
Marco Bozzali ◽  
Elisa Montanaro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Prognostic Value ◽  
Deep Brain

Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study

2019 ◽  
Vol 405 ◽  
pp. 116411 ◽  
Author(s):  
Emma Scelzo ◽  
Ettore Beghi ◽  
Manuela Rosa ◽  
Serena Angrisano ◽  
Angelo Antonini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Pilot Study ◽  
Brain Stimulation ◽  
Deep Brain

scholarly journals Deep Brain Stimulation for Major Depression and Obsessive-Compulsive Disorder—Discontinuation of Ongoing Stimulation

Psych ◽  
2020 ◽  
Vol 2 (3) ◽  
pp. 174-185
Author(s):  
Hannah M. Kilian ◽  
Bettina H. Bewernick ◽  
Margaretha Klein ◽  
Dora M. Meyer ◽  
Susanne Spanier ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Term Treatment ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Long Term Treatment ◽  
Deep Brain

Deep brain stimulation (DBS) is currently under research for the treatment of psychiatric disorders, e.g., obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD). Since the application of DBS in psychiatry has been in use for about 20 years, it is necessary to evaluate its long-term use now. A main issue in the long-term treatment of DBS concerns the effects of a discontinuation of stimulation due to intended as well as unintended reasons. In this contribution, the literature describing discontinuation effects following DBS in OCD and TRD is reviewed. Furthermore, a patient is reported in depth who experienced an unintended discontinuation of supero-lateral medial forebrain bundle (slMFB) DBS for TRD. In this case, the battery was fully depleted without the patient noticing. DBS had led to a sustained response for seven years before discontinuation of stimulation for just several weeks caused a progressive worsening of depression. Altogether, the rapid occurrence of symptom worsening, the absence of a notification about the stimulation status and the difficulties to recapture antidepressant response represent important safety aspects. For a further understanding of the described effects, time courses until worsening of depression as well as biological mechanisms need to be investigated in double-blind controlled trials.

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