Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study

2006 ◽  
Vol 21 (12) ◽  
pp. 2170-2174 ◽  
Author(s):  
Martin Wilhelm Kurz ◽  
Jan Petter Larsen ◽  
Jan Terje Kvaloy ◽  
Dag Aarsland
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Family History ◽  
Community Based ◽  
History Of ◽  
History Of Parkinson’S Disease

Natural History of Parkinson's Disease in the Province of Segovia: Disability in a 20 Years Longitudinal Study

2015 ◽  
Vol 15 (2) ◽  
pp. 87-92 ◽  
Author(s):  
Jacinto Duarte ◽  
Luis Miguel Garc�a Olmos ◽  
Amelia Mendoza ◽  
�ngel Mart�nez Pueyo ◽  
Luis Erik Claver�a
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Natural History ◽  
History Of ◽  
History Of Parkinson’S Disease

scholarly journals Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort

Brain ◽  
2013 ◽  
Vol 136 (2) ◽  
pp. 392-399 ◽  
Author(s):  
Sophie E. Winder-Rhodes ◽  
Jonathan R. Evans ◽  
Maria Ban ◽  
Sarah L. Mason ◽  
Caroline H. Williams-Gray ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural History ◽  
Community Based ◽  
History Of ◽  
Incident Cohort ◽  
History Of Parkinson’S Disease

A Family History of Parkinson’s Disease and Its Effect on Other PD Risk Factors

1999 ◽  
Vol 18 (5) ◽  
pp. 270-278 ◽  
Author(s):  
Benjamin A. Rybicki ◽  
Christine C. Johnson ◽  
Edward L. Peterson ◽  
Gene X. Kortsha ◽  
Jay M. Gorell
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Family History ◽  
History Of ◽  
History Of Parkinson’S Disease

scholarly journals Hunting for Familial Parkinson’s Disease Mutations in the Post Genome Era

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 430
Author(s):  
Steven R. Bentley ◽  
Ilaria Guella ◽  
Holly E. Sherman ◽  
Hannah M. Neuendorf ◽  
Alex M. Sykes ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Family History ◽  
Rare Variants ◽  
Strong Family History ◽  
Disease Mutations ◽  
Whole Exome ◽  
History Of ◽  
Functional Consequences ◽  
Multiplex Families

Parkinson’s disease (PD) is typically sporadic; however, multi-incident families provide a powerful platform to discover novel genetic forms of disease. Their identification supports deciphering molecular processes leading to disease and may inform of new therapeutic targets. The LRRK2 p.G2019S mutation causes PD in 42.5–68% of carriers by the age of 80 years. We hypothesise similarly intermediately penetrant mutations may present in multi-incident families with a generally strong family history of disease. We have analysed six multiplex families for missense variants using whole exome sequencing to find 32 rare heterozygous mutations shared amongst affected members. Included in these mutations was the KCNJ15 p.R28C variant, identified in five affected members of the same family, two elderly unaffected members of the same family, and two unrelated PD cases. Additionally, the SIPA1L1 p.R236Q variant was identified in three related affected members and an unrelated familial case. While the evidence presented here is not sufficient to assign causality to these rare variants, it does provide novel candidates for hypothesis testing in other modestly sized families with a strong family history. Future analysis will include characterisation of functional consequences and assessment of carriers in other familial cases.

Family history of hand tremor in patients with early Parkinson’s disease

2021 ◽  
Vol 90 ◽  
pp. 161-164
Author(s):  
Seong-Min Choi ◽  
Soo Hyun Cho ◽  
Kyung Wook Kang ◽  
Jae-Myung Kim ◽  
Byeong C. Kim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Family History ◽  
Hand Tremor ◽  
History Of ◽  
Early Parkinson’S Disease

scholarly journals The natural history of treated Parkinson's disease in an incident, community based cohort

2011 ◽  
Vol 82 (10) ◽  
pp. 1112-1118 ◽  
Author(s):  
J. R. Evans ◽  
S. L. Mason ◽  
C. H. Williams-Gray ◽  
T. Foltynie ◽  
C. Brayne ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural History ◽  
Community Based ◽  
History Of
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