[123I]?-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy

2001 ◽  
Vol 16 (6) ◽  
pp. 1023-1032 ◽  
Author(s):  
Andrea Varrone ◽  
Kenneth L. Marek ◽  
Danna Jennings ◽  
Robert B. Innis ◽  
John P. Seibyl
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Spect Imaging ◽  
Striatal Dopamine ◽  
Dopamine Transporters ◽  
Reduced Density

Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease

Synapse ◽  
1999 ◽  
Vol 31 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Sylvie Chalon ◽  
Patrick Emond ◽  
Sylvie Bodard ◽  
Marie-Paule Vilar ◽  
Cynthia Thiercelin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Time Course ◽  
D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine Transporters

Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: A cross-sectional study

2014 ◽  
Vol 20 (5) ◽  
pp. 477-481 ◽  
Author(s):  
Edson Bor-Seng-Shu ◽  
Jose Luiz Pedroso ◽  
Andre C. Felicio ◽  
Daniel Ciampi de Andrade ◽  
Manoel Jacobsen Teixeira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Cross Sectional Study ◽  
Striatal Dopamine ◽  
Sectional Study ◽  
Dopamine Transporters ◽  
Cross Sectional ◽  
Substantia Nigra Echogenicity

scholarly journals Serotonin Transporter Availability in Early Stage Parkinson’s Disease and Multiple System Atrophy

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
S. R. Suwijn ◽  
H. W. Berendse ◽  
C. V. M. Verschuur ◽  
R. M. A. de Bie ◽  
J. Booij
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Dopamine Transporter ◽  
Serotonin Transporter ◽  
Disease Duration ◽  
Early Stage ◽  
Spect Imaging ◽  
Parkinsonian Syndrome ◽  
Atypical Parkinsonian Syndrome

Background. Differentiating Parkinson’s disease (PD) from multiple system atrophy (MSA) can be challenging especially early in the course of the disease. Previous studies have shown that midbrain serotonin transporter (SERT) availability in patients with established MSA was significantly lower compared to PD. It is unknown if this is also true for early-stage patients. Methods. 77 early-stage, untreated PD patients were recruited between 1995 and 1998, underwent [123I]β-CIT SPECT imaging, and were followed for at least five years. 16 patients were lost to followup, and in 4 the diagnosis was changed to another atypical parkinsonian syndrome, but not in MSA. In 50 patients, the PD diagnosis was unchanged at followup. In seven patients, the diagnosis was changed to MSA at followup. We retrospectively assessed baseline midbrain SERT availability as well as midbrain SERT-to-striatal dopamine transporter (DAT) ratios. Results. No difference in baseline [123I]β-CIT SERT availability was found. The midbrain SERT-to-striatal DAT ratio for whole striatum was significantly lower in patients with PD compared to MSA (P=0.049). However, when adjusting for the disease duration at imaging this difference is not significant (P=0.070). Conclusion. Midbrain SERT availability is not different between early-stage PD and MSA. Therefore, SERT imaging is not useful to differentiate between early PD and MSA.

scholarly journals Striatal dopamine transporters and cognitive function in Parkinson’s disease

2020 ◽  
Vol 142 (4) ◽  
pp. 385-391
Author(s):  
Jakob Stögbauer ◽  
Florian Rosar ◽  
Ulrich Dillmann ◽  
Klaus Faßbender ◽  
Samer Ezziddin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Striatal Dopamine ◽  
Dopamine Transporters
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