Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy

2001 ◽  
Vol 16 (4) ◽  
pp. 622-630 ◽  
Author(s):  
Bradley F. Boeve ◽  
Michael H. Silber ◽  
Tanis J. Ferman ◽  
John A. Lucas ◽  
Joseph E. Parisi
Keyword(s):  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

HIPPOCAMPAL PERFUSION PREDICTS THE EMERGENCE OF NEURODEGENERATIVE DISEASE IN IDIOPATHIC REM SLEEP BEHAVIOR DISORDER

2011 ◽  
Vol 12 ◽  
pp. S8-S9
Author(s):  
Thien Thanh Dang-Vu ◽  
Jean-François Gagnon ◽  
Mélanie Vendette ◽  
Jean-Paul Soucy ◽  
Ron Postuma ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

scholarly journals Brain Atrophy of Secondary REM-Sleep Behavior Disorder in Neurodegenerative Disease

2016 ◽  
Vol 52 (3) ◽  
pp. 1101-1109 ◽  
Author(s):  
Hee-Jin Kim ◽  
Hyung Kyun Im ◽  
Juhan Kim ◽  
Jee-young Han ◽  
Mony de Leon ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Brain Atrophy ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

scholarly journals Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder

2021 ◽  
Vol 10 (20) ◽  
pp. 4709
Author(s):  
Hyunjin Jo ◽  
Dongyeop Kim ◽  
Jooyeon Song ◽  
Sujung Choi ◽  
Eunyeon Joo
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Sleep Disturbances ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Cpap Therapy ◽  
Sleep Behavior ◽  
Obstructive Sleep

Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 patients with idiopathic RBD (iRBD) and 44 patients with symptomatic RBD (sRBD) with a neurodegenerative disease). Results: Among 226 patients with RBD (male, 61.5%), the mean age at RBD onset and mean disease duration were 59.4 ± 10.5 and 5.9 ± 5.6 years, respectively. Further, 111 (49.1%) patients had periodic limb movements during sleep (PLMS, PLM index ≥ 15/h), while 110 patients (48.7%) had comorbid obstructive sleep apnea (OSA, respiratory disturbance index ≥ 15/h). There was a positive correlation between age at RBD onset and the apnea-hypopnea index and Pittsburgh Sleep Quality Index. Compared to patients with iRBD, patients with sRBD showed a lower N3 sleep (3.3 ± 5.0 vs. 1.6 ± 3.1%, p = 0.004) and higher periodic limb movement index (36.3 ± 31.8 vs. 56.9 ± 47.5/h, p = 0.021) at the baseline. Among the 186 patients with iRBD, 18 (8.0%) developed neurodegenerative diseases (converters, mean follow-up duration: 2.5 ± 1.6 years) and 164 did not (non-converters, mean follow-up 2.4 ± 2.2 years). There was no significant between-group difference in the demographics and baseline clinical features. Continuous positive airway pressure (CPAP) therapy was prescribed in 101 patients with OSA; among them, 71 (70%) patients agreed to use it. CPAP improved dream enactment behaviors. Conclusion: In our study, 8.0% of patients with iRBD showed phenoconversion within a mean follow-up duration of 2.5 years. Polysomnographic parameters could not predict phenoconversion to neurodegenerative disease. However, approximately half of the patients with RBD presented with significant sleep disorders, including OSA or PLMS. CPAP therapy may alleviate RBD symptoms in patients with RBD-OSA.

scholarly journals Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

Neurology ◽  
2008 ◽  
Vol 72 (15) ◽  
pp. 1296-1300 ◽  
Author(s):  
R. B. Postuma ◽  
J. F. Gagnon ◽  
M. Vendette ◽  
M. L. Fantini ◽  
J. Massicotte-Marquez ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior
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