Pilot study of effect of emotional stimuli on tic severity in children with Tourette's syndrome

2003 ◽  
Vol 18 (11) ◽  
pp. 1392-1395 ◽  
Author(s):  
Beatrice L. Wood ◽  
Kendra Klebba ◽  
Olufowbi Gbadebo ◽  
David Lichter ◽  
Roger Kurlan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Emotional Stimuli ◽  
Tic Severity

Remoxipride in Adolescents with Tourette's Syndrome: An Open Pilot Study

1995 ◽  
Vol 5 (2) ◽  
pp. 121-128 ◽  
Author(s):  
JAN K. BUITELAAR ◽  
PEGGY COHEN-KETTENIS ◽  
HERMIEN VLUTTERS ◽  
HERMAN WESTENBERG ◽  
LARS SANDELL
Keyword(s):  
Pilot Study ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Open Pilot

scholarly journals A clinical inventory of moderators of tic severity in Tourette's Syndrome

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S245-S246
Author(s):  
Francesca Conti ◽  
Himanshu Tyagi
Keyword(s):  
Thematic Analysis ◽  
Subjective Effects ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Moderating Variables ◽  
Mesh Terms ◽  
Academic Activities ◽  
Tic Severity ◽  
Peer Victimisation ◽  
Watching Tv

AimsChanges in the severity of tics in Tourette's syndrome (TS), as seen with variations in the intensity or frequency of tics, can be moderated by a variety of independent factors such as external or internal stimuli. Identifying such moderators has important clinical implications as it can aid clinicians in adjusting interventions. Hence, based on our previous review of tic-severity moderators, we developed a clinical inventory of moderating variables for motor and vocal tics for inclusion in the new version of the Queen Square Proforma for Tourette's Syndrome to aid initial assessments in the National Tourette Syndrome Service's Outpatient Clinic for Adults.MethodA review of tic-severity moderators was previously carried out by the authors to investigate the kinds of moderators and their worsening, improving or neutral effects on tic severity. Based on this a semantic thematic analysis of the identified moderators was carried out and themes were developed based on appropriate and relevant MeSH terms in order to create the categories and items of the clinical inventory.ResultSeventy-three different tic severity moderators were identified, the most common being exercise, sleep, peer victimisation, psychosocial stress, watching TV, academic activities and distraction. Twenty-nine themes emerged from the thematic analysis which were then used to update the clinical inventory of tic severity moderators. The review also highlighted the subjectivity of these moderators’ effects on tic severity as some moderators were tic-worsening in some individuals and tic-improving or neutral in others, which is contrary to the current dichotomous understanding.ConclusionThe updated clinical inventory of tic severity moderators invites researchers and clinicians to be more aware of the existence, variability and subjective effects of these tic severity moderators in individuals with TS, as these have been previously looked in a dichotomous way. By better identifying tic-severity moderators and their worsening, improving or neutral effects on tic severity this clinician rated inventory will have potentially important, direct implications for the management and treatment of tics.

Tourette's syndrome in a special education population: A pilot study involving a single school district

Neurology ◽  
1994 ◽  
Vol 44 (4) ◽  
pp. 699-699 ◽  
Author(s):  
R. Kurlan ◽  
D. Whitmore ◽  
C. Irvine ◽  
M. P. McDermott ◽  
P. G. Como
Keyword(s):  
Special Education ◽  
Pilot Study ◽  
School District ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome

A Phase-2 Pilot Study of a Therapeutic Combination of Δ9-Tetrahydracannabinol and Palmitoylethanolamide for Adults With Tourette’s Syndrome

2021 ◽  
pp. appi.neuropsych
Author(s):  
Michael H. Bloch ◽  
Angeli Landeros-Weisenberger ◽  
Jessica A. Johnson ◽  
James F. Leckman
Keyword(s):  
Pilot Study ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Phase 2

scholarly journals Seven Cases of Gilles de la Tourette's Syndrome: Partial Relief with Clonazepam: A Pilot Study

1977 ◽  
Vol 4 (4) ◽  
pp. 279-283 ◽  
Author(s):  
M. Gonce ◽  
A. Barbeau
Keyword(s):  
Pilot Study ◽  
Family History ◽  
Adjuvant Therapy ◽  
Positive Family History ◽  
Clinical Manifestations ◽  
Dopamine Metabolism ◽  
Tourette's Syndrome ◽  
Tourette’S Syndrome ◽  
Controlled Trials ◽  
History Of

SUMMARY:The histories of seven consecutive cases of Gilles de la Tourette's syndrome are presented to exemplify the range of clinical manifestations in this disease and to collate preliminary results with the new benzodiazepine, clonazepam, as a possible adjuvant therapy of this disorder. Controlled trials with clonazepam alone and in association with haloperidol are now justified. Five of our 7 patients had a positive family history of tics, and 2 a confirmed family history of gout. Because clonazepam improves myoclonia and tics and because its mechanism of action possibly involves serotonin, we thought it worthwhile to study simultaneously the relative roles of serotonin and dopamine metabolism in the production of tics, and their relationship to possible defects in purine metabolism in Gilles de la Tourette's syndrome.

Sign in / Sign up

Export Citation Format

Share Document