Body weight gain rate in patients with Parkinson's disease and deep brain stimulation

2003 ◽  
Vol 18 (11) ◽  
pp. 1337-1340 ◽  
Author(s):  
Michela Barichella ◽  
Agnieszka M. Marczewska ◽  
Claudio Mariani ◽  
Andrea Landi ◽  
Antonella Vairo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Body Weight ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Body Weight Gain ◽  
Gain Rate ◽  
Weight Gain Rate ◽  
Deep Brain

scholarly journals The Role of Ghrelin, Neuropeptide Y and Leptin Peptides in Weight Gain after Deep Brain Stimulation for Parkinson’s Disease

2012 ◽  
Vol 90 (2) ◽  
pp. 104-112 ◽  
Author(s):  
Elli Markaki ◽  
John Ellul ◽  
Zinovia Kefalopoulou ◽  
Eftichia Trachani ◽  
Anastasia Theodoropoulou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Neuropeptide Y ◽  
Brain Stimulation ◽  
Deep Brain

50 Body weight trajectories in patients with Parkinson’s disease with and without deep brain stimulation

2021 ◽  
Author(s):  
Julia Steinhardt ◽  
Laura Lokowandt ◽  
Dirk Rasche ◽  
Volker Tronnier ◽  
Thomas Münte ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Body Weight ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Weight Trajectories ◽  
Deep Brain

Weight gain after subthalamic nucleus deep brain stimulation in Parkinson’s disease is influenced by dyskinesias’ reduction and electrodes’ position

2017 ◽  
Vol 38 (12) ◽  
pp. 2123-2129 ◽  
Author(s):  
Roberta Balestrino ◽  
Damiano Baroncini ◽  
Mario Fichera ◽  
Carmine Antonio Donofrio ◽  
Alberto Franzin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Deep Brain

Body weight gain and deep brain stimulation

2011 ◽  
Vol 310 (1-2) ◽  
pp. 267-270 ◽  
Author(s):  
Isabelle Rieu ◽  
Philippe Derost ◽  
Miguel Ulla ◽  
Ana Marques ◽  
Bérangère Debilly ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Body Weight Gain ◽  
Deep Brain

Body weight gain in patients with bilateral deep brain stimulation for dystonia

2015 ◽  
Vol 123 (3) ◽  
pp. 261-267 ◽  
Author(s):  
Marc E. Wolf ◽  
Hans-Holger Capelle ◽  
Götz Lütjens ◽  
Anne D. Ebert ◽  
Michael G. Hennerici ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Body Weight Gain ◽  
Deep Brain

Sweets for my sweet: modulation of the limbic system drives salience for sweet foods after deep brain stimulation in Parkinson’s disease

2021 ◽  
pp. jnnp-2021-326280
Author(s):  
Julia Steinhardt ◽  
Henrike Hanssen ◽  
Marcus Heldmann ◽  
Alexander Neumann ◽  
Alexander Münchau ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Body Weight ◽  
Deep Brain Stimulation ◽  
Functional Connectivity ◽  
Brain Stimulation ◽  
Sweet Food ◽  
Local Impact ◽  
Stn Dbs ◽  
Deep Brain

BackgroundAn increase in body weight is observed in the majority of patients with Parkinson’s disease (PD) who undergo deep brain stimulation (DBS) of the subthalamic nucleus (STN) although the mechanisms are unclear.ObjectivesTo identify the stimulation-dependent effects on reward-associated and attention-associated neural networks and to determine whether these alterations in functional connectivity are associated with the local impact of DBS on different STN parcellations.MethodsWe acquired functional task-related MRI data from 21 patients with PD during active and inactive STN DBS and 19 controls while performing a food viewing paradigm. Electrode placement in the STN was localised using a state-of-the-art approach. Based on the 3D model, the local impact of STN DBS was estimated.ResultsSTN DBS resulted in a mean improvement of motor function of 22.6%±15.5% (on medication) and an increase of body weight of ~4 kg within 2 years of stimulation. DBS of the limbic proportion of the STN was associated with body weight gain and an increased functional connectivity within the salience network and at the same time with a decreased activity within the reward-related network in the context of sweet food images.ConclusionsOur findings indicate increased selective attention for high-caloric foods and a sweet food seeking-like behaviour after DBS particularly when the limbic proportion of the STN was stimulated.

scholarly journals Effects of implantation of a deep brain stimulation device on patient weight in Parkinson’s disease and essential tremor

2020 ◽  
pp. 1-7
Author(s):  
Nikolas R. Monteferrante ◽  
Brian G. Wilhelmi ◽  
Margaret Lambert ◽  
Francisco A. Ponce
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Weight Gain ◽  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Patient Characteristics ◽  
Target Site ◽  
Deep Brain

OBJECTIVEDeep brain stimulation (DBS) is a well-established therapy for treating neurological movement disorders. Some patients who have received DBS therapy have noticed significant weight gain. Further investigation into correlations between patient characteristics and weight gain following DBS device implantation, which the authors here have done, will provide physicians with useful clinical information.METHODSThe authors performed a retrospective study of patients with Parkinson’s disease (PD) and essential tremor (ET) who had received DBS therapy in the period from 2012 to 2017. Patient weights had been recorded preoperatively and at 3, 6, and 12 months postoperatively. These data were used to compare patient characteristics, including diagnosis, body mass index (BMI), sex, levodopa equivalent dose (LED), and change in Unified Parkinson’s Disease Rating Scale (UPDRS) score. For PD patients, a quantile multivariate regression analysis was used to examine whether significant correlations existed between several of these patient characteristics, as well as age and weight gain following implantation.RESULTSPD patients had gained a significant amount of weight at 3 months (mean [SE] 2.66 [0.428] kg, p < 0.001), 6 months (3.64 [0.492] kg, p < 0.001), and 12 months (4.18 [0.540] kg, p < 0.001) after DBS placement. Patients who had undergone subthalamic nucleus (STN) DBS device placement gained, on average, more weight than the patients with globus pallidus internus (GPi) placement at both 6 months (mean 2.558 [1.020] kg, p = 0.01) and 12 months (2.358 [1.130] kg, p = 0.04). BMI in the STN cohort was greater than that in the GPi cohort at 6 months (mean difference [SE] 2.60 [1.127] kg/m2, p = 0.02) and at 12 months (2.36 [1.112] kg/m2, p = 0.04). A reduction in LED was negatively correlated with weight change at 6 months (r = −0.33, p < 0.001) and 12 months (r = −0.41, p < 0.001). There was no weight gain correlated with DBS therapy for ET.CONCLUSIONSPD patients experienced a significant change in weight over time after DBS therapy, whereas ET patients did not. PD patients with an STN target site experienced greater weight gain, on average, than those with a GPi target site. Furthermore, there was a significant increase in BMI at 6 and 12 months in patients with an STN target compared to that in patients with a GPi target. PD patients whose LED was reduced after DBS gained more weight at 6 and 12 months after surgery than the patients whose LED was kept at the same level or increased.

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