scholarly journals Substantia Nigra Swelling and Dentate Nucleus T2 Hyperintensity May Be Early Magnetic Resonance Imaging Signs of β-Propeller Protein-Associated Neurodegeneration

2018 ◽  
Vol 6 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Camilla Russo ◽  
Anna Ardissone ◽  
Elena Freri ◽  
Serena Gasperini ◽  
Marco Moscatelli ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Dentate Nucleus ◽  
Resonance Imaging ◽  
T2 Hyperintensity ◽  
Imaging Signs

scholarly journals Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease

2021 ◽  
Author(s):  
Lu Wang ◽  
Yayun Yan ◽  
Liyao Zhang ◽  
Yan Liu ◽  
Ruirui Luo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
Clinical Symptoms ◽  
Dopamine Neurons ◽  
Substantia Nigra Pars Compacta ◽  
Resonance Imaging ◽  
Mean Values

AbstractNeuromelanin (NM) is a dark pigment that mainly exists in neurons of the substantia nigra pars compacta (SNc). In Parkinson disease (PD) patients, NM concentration decreases gradually with degeneration and necrosis of dopamine neurons, suggesting potential use as a PD biomarker. We aimed to evaluate associations between NM concentration in in vivo SN and PD progression and different motor subtypes using NM magnetic resonance imaging (NM-MRI). Fifty-four patients with idiopathic PD were enrolled. Patients were divided into groups by subtypes with different clinical symptoms: tremor dominant (TD) group and postural instability and gait difficulty (PIGD) group. Fifteen healthy age-matched volunteers were enrolled as controls. All subjects underwent clinical assessment and NM-MRI examination. PD patients showed significantly decreased contrast-to-noise ratio (CNR) values in medial and lateral SN (P < 0.05) compared to controls. CNR values in lateral SN region decreased linearly with PD progression (P = 0.001). PIGD patients showed significant decreases in CNR mean values in lateral SN compared to TD patients (P = 0.004). Diagnostic accuracy of using lateral substantia nigra (SN) in TD and PIGD groups was 79% (sensitivity 76.5%, specificity 78.6%). NM concentration in PD patients decreases gradually during disease progression and differs significantly between PD subtypes. NM may be a reliable biomarker for PD severity and subtype identification.

Reliability of Magnetic Resonance Imaging Signs of Posterolateral Rotatory Instability of the Elbow

2015 ◽  
Vol 40 (7) ◽  
pp. 1428-1433 ◽  
Author(s):  
Michael Hackl ◽  
Kilian Wegmann ◽  
Christian Ries ◽  
Tim Leschinger ◽  
Klaus Josef Burkhart ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Rotatory Instability ◽  
Posterolateral Rotatory Instability ◽  
Imaging Signs

Postoperative computed tomography and low-field magnetic resonance imaging findings in dogs with degenerative lumbosacral stenosis treated by dorsal laminectomy

2017 ◽  
Vol 30 (02) ◽  
pp. 143-152 ◽  
Author(s):  
Charles Ley ◽  
Kerstin Hansson ◽  
Lennart Sjöström ◽  
Martin Rapp
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Contrast Enhancement ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Spinal Nerves ◽  
Low Field ◽  
Dorsal Laminectomy ◽  
Imaging Signs

SummaryObjectives: To describe postoperative computed tomography (CT) and magnetic resonance imaging (MRI) findings in dogs with degenerative lumbosacral stenosis (DLSS) treated by dorsal laminectomy and partial discectomy.Methods: Prospective clinical case study of dogs diagnosed with and treated for DLSS. Surgical and clinical findings were described. Computed tomography and low field MRI findings pre- and postoperatively were described and graded. Clinical, CT and MRI examinations were performed four to 18 months after surgery.Results: Eleven of 13 dogs were clinically improved and two dogs had unchanged clinical status postoperatively despite imaging signs of neural compression. Vacuum phenomenon, spondylosis, sclerosis of the seventh lumbar (L7) and first sacral (S1) vertebrae endplates and lumbosacral intervertebral joint osteoarthritis became more frequent in postoperative CT images. Postoperative MRI showed mild disc extrusions in five cases, and in all cases contrast enhancing non-discal tissue was present. All cases showed contrast enhancement of the L7 spinal nerves both pre- and postoperatively and seven had contrast enhancement of the lumbosacral intervertebral joints and paraspinal tissue postoperatively. Articular process fractures or fissures were noted in four dogs.Clinical significance: The study indicates that imaging signs of neural compression are common after DLSS surgery, even in dogs that have clinical improvement. Contrast enhancement of spinal nerves and soft tissues around the region of disc herniation is common both pre- and postoperatively and thus are unreliable criteria for identifying complications of the DLSS surgery.Supplementary Material to this article is available online at https://doi.org/10.3415/VCOT-16-06-0096

Magnetic resonance imaging of the substantia nigra in Parkinson's disease

2012 ◽  
Vol 27 (7) ◽  
pp. 822-830 ◽  
Author(s):  
Stéphane Lehéricy ◽  
Michael A. Sharman ◽  
Clarisse Longo Dos Santos ◽  
Raphaël Paquin ◽  
Cecile Gallea
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Resonance Imaging

New Magnetic Resonance Imaging Biomarkers Advance the Characterization of Parkinson Disease

US Neurology ◽  
2013 ◽  
Vol 09 (01) ◽  
pp. 8
Author(s):  
David A Ziegler ◽  
Suzanne Corkin ◽  
◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Substantia Nigra ◽  
Parkinson Disease ◽  
Structural Mri ◽  
Careful Examination ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
Current State ◽  
Magnetic Resonance Imaging Mri

The pathophysiology of idiopathic Parkinson disease (PD) is traditionally characterized as substantia nigra degeneration, but careful examination of the widespread neuropathologic changes suggests individual differences in neuronal vulnerability. A major limitation to studies of disease progression in PD has been that conventional magnetic resonance imaging (MRI) techniques provide relatively poor contrast for the structures that are affected by the disease, and thus are not typically used in experimental or clinical studies. Here, we review the current state of structural MRI as applied to the analysis of the PD brain. We also describe a new multispectral MRI method that provides improved contrast for the substantia nigra and basal forebrain, which we recently used to show that these structures display different trajectories of volume loss early in the disease.

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