Contribution ofO6-methylguanine-DNA methyltransferase to monofunctional alkylating-agent resistance in human brain tumor—derived cell lines

1995 ◽  
Vol 13 (2) ◽  
pp. 70-80 ◽  
Author(s):  
Michael S. Bobola ◽  
A. Blank ◽  
Mitchel S. Berger ◽  
John R. Silber
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Cell Lines ◽  
Dna Methyltransferase ◽  
Alkylating Agent ◽  
Human Brain Tumor ◽  
Methylguanine Dna Methyltransferase

Synthesis and in vitro cytotoxic activity of novel hexahydro-2H-pyrido[1,2-b]isoquinolines against human brain tumor cell lines

1997 ◽  
Vol 7 (23) ◽  
pp. 2945-2950 ◽  
Author(s):  
Axel Monsees ◽  
Sabine Laschat ◽  
Marc Hotfilder ◽  
Johannes Wolff ◽  
Klaus Bergander ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Brain Tumor Cell

scholarly journals Expression of PPARγ and Its Ligand-dependent Growth Inhibition in Human Brain Tumor Cell Lines

2002 ◽  
Vol 93 (6) ◽  
pp. 660-666 ◽  
Author(s):  
Mihoko Kato ◽  
Takashi Nagaya ◽  
Miyuki Fujieda ◽  
Kiyoshi Saito ◽  
Jun Yoshida ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Brain Tumor Cell ◽  
Dependent Growth

Caffeine and Staurosporine Enhance the Cytotoxicity of Cisplatin and Camptothecin in Human Brain Tumor Cell Lines

1998 ◽  
Vol 243 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Anna J. Janss ◽  
Cindy Levow ◽  
Eric J. Bernhard ◽  
Ruth J. Muschel ◽  
W.Gilles McKenna ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Brain Tumor Cell

Human brain tumor--derived cell lines: growth rate reduced by human fibroblast interferon

Science ◽  
1983 ◽  
Vol 219 (4586) ◽  
pp. 881-883 ◽  
Author(s):  
A. Cook ◽  
W. Carter ◽  
F Nidzgorski ◽  
L Akhtar
Keyword(s):  
Growth Rate ◽  
Brain Tumor ◽  
Human Brain ◽  
Cell Lines ◽  
Human Fibroblast ◽  
Human Brain Tumor

ChemInform Abstract: Synthesis and in vitro Cytotoxic Activity of Novel Hexahydro-2H-pyrido[1,2-b]isoquinolines Against Human Brain Tumor Cell Lines.

ChemInform ◽  
2010 ◽  
Vol 29 (12) ◽  
pp. no-no
Author(s):  
A. MONSEES ◽  
S. LASCHAT ◽  
M. HOTFILDER ◽  
J. WOLFF ◽  
K. BERGANDER ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Brain Tumor Cell

scholarly journals Effects of Electroporation on Anticancer Activity of 5-FU and Newly Synthesized zinc(II) Complex in Chemotherapy-resistance Human Brain Tumor Cells

2021 ◽  
Author(s):  
Mehmet Eşref Alkış ◽  
Nevin Turan ◽  
Yusuf Alan ◽  
Sevgi Irtegun Kandemir ◽  
Kenan Buldurun
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Human Brain ◽  
Cell Lines ◽  
Dermal Fibroblast ◽  
Cytotoxic Activities ◽  
Tumor Cell Lines ◽  
Human Brain Tumor ◽  
Combined Application ◽  
Brain Tumor Cell

Abstract Zn(II) complex of Schiff base derived from the condensation of 4-aminopyrimidine-2(1H)-one with salicylaldehyde was prepared and characterized by various physico‐chemical and spectral methods for structure determination. The cytotoxic activity of the Zn(II) complex was investigated in comparison with 5-fluorouracil (5-FU) against two different human brain tumor cell lines (T98G and U118), while primer human dermal fibroblast cells (HDF) was used as control for biocompatibility. Then, the effectiveness of electroporation (EP) on cytotoxic activities of these compounds has been examined. The cytotoxicities of the 5-FU and new Zn(II) complex, alone or in combination with electroporation, were determined by MTT assay. The Zn(II) complex showed good cytotoxicity against T98G and U118 brain tumor cell lines with IC50 = 282.47 and 297.91 μM respectively, while it was safe on HDF healthy cells with IC50 = 826.72 μM. The 5-FU exhibited less cytotoxicity compared to the Zn(II) complex against T98G (IC50 = 382.35 μM) and U118 (IC50 = 396.56 μM) tumor cell lines. The combined application of Zn (II) + EP decreased the IC50 value by 5.96-fold in T98G cells and 4.76-fold in U118 cells. EP showed a similar effect in its combined application with 5-FU, resulting in a decrease of the IC50 value of 4.22-fold in the T98G cells and 3.84-fold in the U118 cells. In a conclusion, the Zn(II) complex exhibited an anticancer potential against both brain tumor cell lines (T98G and U118) and EP greatly increased the cytotoxicity of Zn(II) complex and 5-FU on these chemotherapy-resistant cells.

O6-Methylguanine-DNA Methyltransferase, O6-Benzylguanine, and Resistance to Clinical Alkylators in Pediatric Primary Brain Tumor Cell Lines

2005 ◽  
Vol 11 (7) ◽  
pp. 2747-2755 ◽  
Author(s):  
Michael S. Bobola ◽  
John R. Silber ◽  
Richard G. Ellenbogen ◽  
J. Russell Geyer ◽  
A. Blank ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Cell ◽  
Cell Lines ◽  
Dna Methyltransferase ◽  
Primary Brain Tumor ◽  
Tumor Cell Lines ◽  
Methylguanine Dna Methyltransferase ◽  
Brain Tumor Cell
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