Association of induction of a fully tumorigenic phenotype in murine radiation-induced T-lymphoma cells with loss of differentiation antigens, gain of CD44, and alterations in p53 protein levels

1992 ◽  
Vol 5 (3) ◽  
pp. 190-198 ◽  
Author(s):  
Ruth A. Gjerset ◽  
Jyoti Arya ◽  
Sarah Volkman ◽  
Martin Haas
Keyword(s):  
P53 Protein ◽  
Lymphoma Cells ◽  
Differentiation Antigens ◽  
Protein Levels ◽  
T Lymphoma Cells ◽  
Radiation Induced ◽  
T Lymphoma

Modulation of Radiation-Induced Apoptosis and G 2 /M Block in Murine T-Lymphoma Cells

1995 ◽  
Vol 141 (3) ◽  
pp. 235 ◽  
Author(s):  
Sanjeewani T. Palayoor ◽  
Roger M. Macklis ◽  
Edward A. Bump ◽  
C. Norman Coleman
Keyword(s):  
Lymphoma Cells ◽  
T Lymphoma Cells ◽  
Radiation Induced ◽  
T Lymphoma ◽  
Induced Apoptosis

Role of selectins in the triggering, growth, and dissemination of T-lymphoma cells: implication of L-selectin in the growth of thymic lymphoma

Blood ◽  
2005 ◽  
Vol 105 (12) ◽  
pp. 4800-4806 ◽  
Author(s):  
Simon D. Bélanger ◽  
Yves St-Pierre
Keyword(s):  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Lymphoma Cells ◽  
Peripheral Tissues ◽  
Thymic Lymphoma ◽  
Definitive Evidence ◽  
T Lymphoma Cells ◽  
Radiation Induced ◽  
T Lymphoma ◽  
Deficient Mice

Abstract We previously showed that intercellular adhesion molecule-1 (ICAM-1) expression by the host is essential for lymphoma dissemination. Because selectins usually act in a coordinated fashion with ICAM-1 in the recruitment of circulating normal cells, we investigated their implication in lymphomagenesis and metastasis. Using selectin-deficient mice, we found that though the absence of E-, P-, or L-selectins did not affect the triggering of radiation-induced thymic lymphoma, the absence of L-selectin on lymphoma cells reduced their capacity to grow in the thymus. This defect, however, was overcome by altering the integrity of the L-selectin-mediated interactions in the thymus, as shown in L-selectin-deficient mice and by adoptive transfer experiments. We also found that lack of selectin expression by the host significantly delayed the dissemination of lymphomas to peripheral tissues. This resistance of selectin-deficient mice to lymphoma metastasis was dependent on the intrinsic properties of lymphoma cells because highly tumorigenic variants were insensitive to the absence of selectins. Observations that lymphoma cells disseminate with the same efficiency in normal and selectin-deficient mice suggest that selectins exert their influence at the posthoming stage of metastasis, as does ICAM-1. These results provide definitive evidence that selectins play a significant role at different steps of T-cell lymphoma development. (Blood. 2005;105:4800-4806)

scholarly journals The p27–Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells

Cell Cycle ◽  
2013 ◽  
Vol 12 (16) ◽  
pp. 2625-2635 ◽  
Author(s):  
Michael K Kullmann ◽  
Claudia Grubbauer ◽  
Katrin Goetsch ◽  
Heidelinde Jäkel ◽  
Silvio R Podmirseg ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Lymphoma Cells ◽  
Cycle Arrest ◽  
T Lymphoma Cells ◽  
T Lymphoma

scholarly journals Ryanodine Receptor-Ankyrin Interaction Regulates Internal Ca Release in Mouse T-lymphoma Cells

1995 ◽  
Vol 270 (30) ◽  
pp. 17917-17922 ◽  
Author(s):  
Lilly Y. W. Bourguignon ◽  
Arthur Chu ◽  
H. Jin ◽  
Neil R. Brandt
Keyword(s):  
Ryanodine Receptor ◽  
Lymphoma Cells ◽  
T Lymphoma Cells ◽  
T Lymphoma

Isolation of Thy-1 caps and analysis of their phospholipid composition in mouse T-lymphoma cells

1988 ◽  
Vol 134 (1) ◽  
pp. 67-77 ◽  
Author(s):  
Suzanne J. Suchard ◽  
Hilda K. Lo ◽  
Lilly Y. W. Bourguignon
Keyword(s):  
Phospholipid Composition ◽  
Lymphoma Cells ◽  
T Lymphoma Cells ◽  
T Lymphoma

Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells

2012 ◽  
Vol 29 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Robert Werdehausen ◽  
Sebastian Braun ◽  
Sepideh Fazeli ◽  
Henning Hermanns ◽  
Markus W. Hollmann ◽  
...  
Keyword(s):  
Local Anaesthetic ◽  
Major Determinant ◽  
Lymphoma Cells ◽  
T Lymphoma Cells ◽  
T Lymphoma
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