Hyperactivation of MEK/ERK pathway by Ca 2+ /calmodulin‐dependent protein kinase kinase 2 promotes cellular proliferation by activating cyclin‐dependent kinases and minichromosome maintenance protein in gastric cancer cells

2021 ◽  
Author(s):  
Mohd. A. Najar ◽  
Anjana Aravind ◽  
Shobha Dagamajalu ◽  
David Sidransky ◽  
Hassan Ashktorab ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cellular Proliferation ◽  
Erk Pathway ◽  
Minichromosome Maintenance ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cyclin Dependent Kinases ◽  
Dependent Protein ◽  
Minichromosome Maintenance Protein ◽  
Protein Kinase Kinase

scholarly journals Type II cGMP-dependent protein kinase inhibits ligand-induced activation of EGFR in gastric cancer cells

2014 ◽  
Vol 9 (4) ◽  
pp. 1405-1409 ◽  
Author(s):  
LU JIANG ◽  
YONGCHANG CHEN ◽  
YUEYING LI ◽  
TING LAN ◽  
MIN WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells

2013 ◽  
Vol 1 (3) ◽  
pp. 399-404 ◽  
Author(s):  
LU JIANG ◽  
YONGCHANG CHEN ◽  
JIANRONG SANG ◽  
YUEYING LI ◽  
TING LAN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals lncRNA ABHD11-AS1 drives gastric cancer development by targeting miR-1301-3p/PDPK1 signaling

2019 ◽  
Author(s):  
hairong xin ◽  
zhefeng yan ◽  
jie cao
Keyword(s):  
Gastric Cancer ◽  
Biological Effects ◽  
Annexin V ◽  
Immunohistochemical Analysis ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Downstream Target ◽  
Normal Tissues ◽  
Proliferation And Apoptosis ◽  
Dependent Protein

Abstract Background Long noncoding RNAs (lncRNAs) has long been reported to associate with multitudinous kinds of cancer. The ABHD11-AS1, a newly identified lncRNAs, has been demonstrated as a new marker of gastric cancer (GC). In this study, a significant upregulation of ABHD11-AS1 was observed in GC, compared to adjacent normal tissues. Method Immunohistochemical analysis for ABHD11-AS1, 3-phosphoinositide dependent protein kinase 1 (PDPK1), miR-1301-3p was performed on gastric tumor and adjacent normal tissues. The gene expression was evaluated by qRT-PCR. The proliferation was assayed by CCK8 and Annexin V/PI assay. Results ABHD11-AS1 is highly expressed in GC tissues compared with adjacent normal tissues(*p<0.01) Knock-down of ABHD11-AS1 could suppress the aberrant proliferation of GC cells compared with si-Scramble(*p<0.01). LncRNA-ABHD11-AS1 served as a sponge for miR-1301-3p in GC cell. miR-1301-3p/ABHD11-AS1 regulated the expression of PDPK1 in GC cells compared with control *p<0.01). miR-1301-3p/ ABHD11-AS1 co-mediated proliferation and apoptosis of GC cell compared with si-Scramble/Mock and si-ABHD11-AS1/Mock (*p<0.01) Conclusion PDPK1 was a downstream target of miR-133a-3p and ABHD11-AS1 subsequently exerted its biological effects via modulating the expression of PDPK1in gastric cancer cells. Key lncRNA,ABHD11-AS1, gastric cancer, miR-1301-3p, PDPK1

Sign in / Sign up

Export Citation Format

Share Document