scholarly journals Single‐nucleotide polymorphism rs13426236 contributes to an increased prostate cancer risk via regulating MLPH splicing variant 4

2019 ◽  
Vol 59 (1) ◽  
pp. 45-55
Author(s):  
Fankai Xiao ◽  
Peng Zhang ◽  
Yuan Wang ◽  
Yijun Tian ◽  
Michael James ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Splicing Variant

scholarly journals Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population

2016 ◽  
Vol 7 (3) ◽  
pp. 491-498 ◽  
Author(s):  
Mohammad Hashemi ◽  
Nazanin Moradi ◽  
Seyed Amir Mohsen Ziaee ◽  
Behzad Narouie ◽  
Mohammad Hosein Soltani ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Iranian Population ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals A single nucleotide polymorphism in CYP1B1 leads to differential prostate cancer risk and telomere length

2018 ◽  
Vol 9 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Cheng-Yuan Gu ◽  
Gao-Xiang Li ◽  
Yu Zhu ◽  
Hua Xu ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Cancer Risk ◽  
Telomere Length ◽  
Prostate Cancer Risk ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

388: Single Nucleotide Polymorphism (SNP) and Splicing Variant in C-Terminal Region of TCF-4 Gene are Related to the Pathogenesis of Prostate Cancer

2005 ◽  
Vol 173 (4S) ◽  
pp. 106-106
Author(s):  
Hiroaki Shiina ◽  
Hideki Enokida ◽  
Shinji Urakami ◽  
Tatsuya Ogishima ◽  
Toshifumi Kawakami ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Terminal Region ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Splicing Variant

scholarly journals Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at Prostate Cancer Risk Loci

Genes ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 547 ◽  
Author(s):  
Peng Zhang ◽  
Lori S. Tillmans ◽  
Stephen N. Thibodeau ◽  
Liang Wang
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Single Nucleotide Polymorphisms ◽  
Protein Binding ◽  
Prostate Cancer Risk ◽  
Sequencing Analysis ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Functional Variants ◽  
Dependent Protein

Genome-wide association studies have identified over 150 risk loci that increase prostate cancer risk. However, few causal variants and their regulatory mechanisms have been characterized. In this study, we utilized our previously developed single-nucleotide polymorphisms sequencing (SNPs-seq) technology to test allele-dependent protein binding at 903 SNP sites covering 28 genomic regions. All selected SNPs have shown significant cis-association with at least one nearby gene. After preparing nuclear extract using LNCaP cell line, we first mixed the extract with dsDNA oligo pool for protein–DNA binding incubation. We then performed sequencing analysis on protein-bound oligos. SNPs-seq analysis showed protein-binding differences (>1.5-fold) between reference and variant alleles in 380 (42%) of 903 SNPs with androgen treatment and 403 (45%) of 903 SNPs without treatment. From these significant SNPs, we performed a database search and further narrowed down to 74 promising SNPs. To validate this initial finding, we performed electrophoretic mobility shift assay in two SNPs (rs12246440 and rs7077275) at CTBP2 locus and one SNP (rs113082846) at NCOA4 locus. This analysis showed that all three SNPs demonstrated allele-dependent protein-binding differences that were consistent with the SNPs-seq. Finally, clinical association analysis of the two candidate genes showed that CTBP2 was upregulated, while NCOA4 was downregulated in prostate cancer (p < 0.02). Lower expression of CTBP2 was associated with poor recurrence-free survival in prostate cancer. Utilizing our experimental data along with bioinformatic tools provides a strategy for identifying candidate functional elements at prostate cancer susceptibility loci to help guide subsequent laboratory studies.

scholarly journals No Association between TERT-CLPTM1L Single Nucleotide Polymorphism rs401681 and Mean Telomere Length or Cancer Risk

2010 ◽  
Vol 19 (7) ◽  
pp. 1862-1865 ◽  
Author(s):  
Karen A. Pooley ◽  
Jonathan Tyrer ◽  
Mitul Shah ◽  
Kristy E. Driver ◽  
Jean Leyland ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cancer Risk ◽  
Telomere Length ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

A single nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer

2002 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Bas Verhage ◽  
Kjeld van Houwelingen ◽  
Emiel Ruijter ◽  
Bart Kiemeney ◽  
Jack Schalken
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
Gene Promoter ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
E Cadherin

In silico analysis of non-synonymous single nucleotide polymorphism in a human KLK-2 gene associated with prostate cancer

Meta Gene ◽  
2019 ◽  
Vol 21 ◽  
pp. 100578
Author(s):  
Tooba Yousefi ◽  
Seyed Mostafa Mir ◽  
Jahanbakhsh Asadi ◽  
Mehdi Tourani ◽  
Ansar Karimian ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Nucleotide Polymorphism ◽  
In Silico ◽  
In Silico Analysis ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Silico Analysis
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