A supercritical CO2 extract of neem leaf (A. indica ) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways

2018 ◽  
Vol 57 (9) ◽  
pp. 1156-1165 ◽  
Author(s):  
Mandakini J. Patel ◽  
Shreya Tripathy ◽  
Keya D. Mukhopadhyay ◽  
Tamna Wangjam ◽  
April B. Cabang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Supercritical Co2 ◽  
Preclinical Models ◽  
Inflammatory Pathways ◽  
Supercritical Co2 Extract

Comparative analysis of the oil and supercritical CO2 extract of Artemisia sieberi

2007 ◽  
Vol 79 (1) ◽  
pp. 306-311 ◽  
Author(s):  
Ensieh Ghasemi ◽  
Yadollah Yamini ◽  
Nader Bahramifar ◽  
Fatemmeh Sefidkon
Keyword(s):  
Comparative Analysis ◽  
Supercritical Co2 ◽  
Artemisia Sieberi ◽  
Supercritical Co2 Extract

scholarly journals Animal models of gastrointestinal and liver diseases. New mouse models for studying dietary prevention of colorectal cancer

2014 ◽  
Vol 307 (3) ◽  
pp. G249-G259 ◽  
Author(s):  
James C. Fleet
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mouse Models ◽  
Human Colon ◽  
Low Grade ◽  
Preclinical Models ◽  
Dietary Interventions ◽  
Single Model ◽  
Human Colon Cancer ◽  
Molecular Etiology

Colorectal cancer is a heterogeneous disease that is one of the major causes of cancer death in the U.S. There is evidence that lifestyle factors like diet can modulate the course of this disease. Demonstrating the benefit and mechanism of action of dietary interventions against colon cancer will require studies in preclinical models. Many mouse models have been developed to study colon cancer but no single model can reflect all types of colon cancer in terms of molecular etiology. In addition, many models develop only low-grade cancers and are confounded by development of the disease outside of the colon. This review will discuss how mice can be used to model human colon cancer and it will describe a variety of new mouse models that develop colon-restricted cancer as well as more advanced phenotypes for studies of late-state disease.

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